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Chirine Toufaily, Gauthier Schang, Xiang Zhou, Philipp Wartenberg, Ulrich Boehm, John P Lydon, Ferdinand Roelfsema and Daniel J Bernard

, stimulates GnRH release ( Messager et al . 2005 , d’Anglemont de Tassigny et al . 2008 ). In the pituitary, high levels of estrogens increase the sensitivity of gonadotrope cells to GnRH, amplifying LH release ( Lasley et al . 1975 , Dafopoulos et al

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Romain Fontaine, Eirill Ager-Wick, Kjetil Hodne and Finn-Arne Weltzien

Introduction Gonadotropes are key players in the control of the reproductive function as part of the brain-pituitary-gonad axis ( Harris 1951 , Weltzien et al . 2004 ). Located in the anterior part of the pituitary, they produce the two

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Xiang Zhou, Ying Wang, Luisina Ongaro, Ulrich Boehm, Vesa Kaartinen, Yuji Mishina and Daniel J Bernard

Introduction The pituitary glycoprotein follicle-stimulating hormone (FSH) is an essential regulator of ovarian function and testicular development in mammals. FSH synthesis by pituitary gonadotrope cells is primarily stimulated by

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Audrey F Seasholtz, Miina Öhman, Amale Wardani and Robert C Thompson

the rat pituitary ( Potter et al . 1994 , Van Pett et al . 2000 ). Recent studies from our laboratory have demonstrated Crhr1 mRNA not only in a subset of corticotropes but also in a subset of lactotropes and gonadotropes in murine anterior

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Beata Bak, Laura Carpio, Jinjing L Kipp, Pankaj Lamba, Ying Wang, Ren-Shan Ge, Matthew P Hardy, Kelly E Mayo and Daniel J Bernard

a , b , Vale et al . 1986 ). The ligands were subsequently shown to act largely in an autocrine/paracrine fashion in gonadotrope cells to regulate transcription of the FSHβ ( Fshb ) subunit gene, the rate-limiting step in the synthesis of dimeric

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J E Sánchez-Criado, J Martín de las Mulas, C Bellido, V M Navarro, R Aguilar, J C Garrido-Gracia, M M Malagón, M Tena-Sempere and A Blanco

Introduction In the rat, ovarian oestrogen regulates synthesis and release of gonadotrophins acting on intracellular oestrogen receptor (ER) in the gonadotrope. Synthesis and release of gonadotrophins are distinct and differentially

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Kathleen R Sedgley, Ann R Finch, Christopher J Caunt and Craig A McArdle

and 50 000 sites/cell for the mGnRHR and the sGnRHR respectively). These values are similar to those estimated for endogenous GnRHRs of rat and sheep pituitaries or murine gonadotrope-derived cell lines (approximately 20 000–80 000 sites per

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Ann R Finch, Kathleen R Sedgley, Christopher J Caunt and Craig A McArdle

. LβT2 cells (gonadotrope lineage cells provided by Prof. P Mellon, University of San Diego, CA, USA) were maintained in serum-supplemented DMEM ( Hislop et al . 2005 ) in Matrigel-coated T75 flasks. For experiments, they were plated (2500 cells

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Judith L Turgeon and Dennis W Waring

signal during the LH surge is GnRH self-priming, and we have shown for rat gonadotropes that there is overlap of the self-priming pathway with activation of the progesterone receptor (PR; Waring & Turgeon 1992 , Turgeon & Waring 1994 ). For mouse

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J E Sánchez-Criado, J Martín de las Mulas, C Bellido, R Aguilar and J C Garrido-Gracia

action are lactotropes, where oestrogens stimulate synthesis and secretion of prolactin (PRL) ( Ben-Jonathan 1994 ), and gonadotropes, where oestrogens sensitize the pituitary to gonadotrophin-releasing hormone (GnRH) and elicit GnRH self-priming ( Fink