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Rajat K Das, Sarmistha Banerjee and Bernard H Shapiro

differences in CYP expression occurs postpubertally) ( Shapiro et al . 1995 ). The only endogenous factor known to regulate the expression of adult hepatic CYP is growth hormone (GH) ( Legraverend et al . 1992 , Shapiro et al . 1995 ). At puberty, males

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Zhengxiang Huang, Lili Huang, Chengjian Wang, Shanli Zhu, Xinzhou Qi, Yang Chen, Yanjun Zhang, Michael A Cowley, Johannes D Veldhuis and Chen Chen

Introduction Hormonal disturbance, in either secretion amount or function, often occurs in parallel with impairment of glucose/lipid/protein metabolism in obesity. Two pivotal hormones, insulin and growth hormone (GH), which synergistically

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Christoph Schmid, Marian C Neidert, Oliver Tschopp, Lisa Sze and René L Bernays

Introduction This review on growth hormone (GH) and Klotho covers novel findings on a well-known hormone, the first to be extracted and characterized from the pituitary gland, and a more recently, accidentally discovered multifunctional protein. To

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John A H Wass and Raghava Reddy

Introduction Much has been written about the effects of growth hormone (GH) replacement therapy in GH-deficient human subjects on growth, body composition, cardiovascular risk factors, bone and muscle development and quality of life. When properly

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J T Smith, A Roseweir, M Millar, I J Clarke and R P Millar

physiological status to reproduction ( Pineda et al . 2010 a ). Growth hormone (GH) plays a role in normal reproductive function ( Hull & Harvey 2001 , 2002 ) and in metabolic regulation. A substantial number of studies have now reported effects of

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Rita Sharma, Quyen Luong, Vishva M Sharma, Mitchell Harberson, Brian Harper, Andrew Colborn, Darlene E Berryman, Niels Jessen, Jens Otto Lunde Jørgensen, John J Kopchick, Vishwajeet Puri and Kevin Y Lee

Introduction Although growth hormone (GH) has been primarily studied for its effects on linear growth, pronounced stimulation of lipolysis was among the first metabolic effects reported in human subjects following the introduction of pituitary

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A. L. Ogilvy-Stuart and S. M. Shalet

In a child, puberty encompasses a series of events which include the completion of growth and the maturing of the reproductive system. One of the common hormonal links between these two processes is growth hormone (GH) and, although it has been known for some time that the reproductive axis influences GH secretion and growth, increasing interest is developing in the alternative possibility of GH modifying reproductive processes.

In the normal child, there is an increase in GH secretion from mid-childhood with a shift in periodicity and an increase in pulse amplitude (Hindmarsh, Mathews & Brook, 1988). The two- to threefold rise in GH secretion during puberty is a product of the increase in pulse amplitude over the prepubertal value (Martha, Rogol, Veldhuis et al. 1989; Delemarre-van de Waal, Wennink & Odink, 1991). GH pulse amplitude is increased during early puberty in girls and at a later stage in boys, corresponding

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C. G. D. Brook, P. C. Hindmarsh and R. Stanhope

The Endocrine Unit, Cobbold Laboratories, Middlesex Hospital, London win 8aa *Department of Growth and Development, Institute of Child Health, Guilford Street, London wcin 1eh REVISED MANUSCRIPT RECEIVED 26 April 1988


The human growth curve divides into three distinct time-spans. There is a period of rapid and rapidly decelerating growth during infancy. This changes in the third year to a period of steady and slowly decelerating growth during childhood. Growth is completed by the adolescent growth spurt which, because it occurs later and is slightly greater in magnitude in boys than in girls, accounts for the sex differences in adult height.

Growth in infancy

Clinical observation of patients born with congenital hypopituitarism indicates clearly that growth hormone is important for growth from the day of birth. On the other hand, it seems likely that nutritional influences play the major role in fetal and infantile growth; such

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Maria Alba and Roberto Salvatori

Introduction The production and secretion of growth hormone (GH) from the anterior pituitary is stimulated by the hypothalamic growth hormone releasing hormone (GHRH) and inhibited by somatostatin ( Muller et al. 1999 ). GHRH is

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Chicken growth hormone has been isolated from adenohypophysial tissue from which the glycoprotein hormones had been removed. The procedure entailed alkali extraction, ammonium sulphate precipitation and ion-exchange chromatography on DEAE-cellulose. The resulting fraction was homogeneous, active in the rat tibia bioassay and had a similar isoelectric point, molecular weight and amino acid composition to mammalian growth hormone. A specific homologous radioimmunoassay has been developed using the avian growth hormone.