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Christopher A Price Faculty of Veterinary Medicine, Centre de recherche en reproduction animale, University of Montreal, 3200 rue Sicotte, St‐Hyacinthe, Quebec, Canada J2S 7C6

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drivers of many stages of follicle development; however, it is becoming increasingly evident that several families of growth factors also play important roles within the follicle, including the insulin-like growth factor and transforming growth factor beta

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0414
Volume/Issue:
Volume 228: Issue 2
Free access
Amanda K Mauro Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Nauman Khurshid Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Danielle M Berdahl Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Amanda C Ampey Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Daniel Adu Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Department of Pediatrics, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Dinesh M Shah Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA
Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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Derek S Boeldt Perinatal Research Laboratories, Department of Obstetrics & Gynecology, University of Wisconsin – Madison, School Medicine and Public Health, Madison, Wisconsin, USA

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nitric oxide (NO) production. In pregnancy, there are changes in levels of many growth factors and cytokines as compared to the non-pregnant state, and further changes occur in PE compared to normal pregnancies. Stimulation of kinase signaling cascades

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0397
Volume/Issue:
Volume 248: Issue 2
Restricted access
Rukmani Pandey Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Pallavi Shukla Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, India

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Baby Anjum Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

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Himanshu Pawankumar Gupta Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India
Embryotoxicology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, India

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Subhashis Pal Division of Endocrinology, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India

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Nidhi Arjaria Electron Microscopy Laboratory, CSIR-Indian Institute of Toxicology Research (CSIR–IITR), Vishvigyan Bhawan, Lucknow, Uttar Pradesh, India

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Keerti Gupta Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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Naibedya Chattopadhyay Division of Endocrinology, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India

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Rohit A Sinha Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

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Sanghamitra Bandyopadhyay Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhavan, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

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autophagy and whether the latter related to apoptosis, cognitive impairments or had any association with mitochondria awaits investigation. The intersection between growth factors, apoptosis and autophagy serves as an attractive target for disease

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0197
Volume/Issue:
Volume 244: Issue 1
Restricted access
Jitendra Vishwakarma Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Keerti Gupta Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Juhi Mishra Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Asmita Garg Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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Rafat Malik Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Amit Kashyap Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Manoj Shukla Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India

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Dhirendra Singh Central Pathology Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR–IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India

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Sanghamitra Bandyopadhyay Developmental Toxicology Laboratory, Systems Toxicology & Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow-226001, Uttar Pradesh, India
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

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played a critical role in hypothyroidism-induced hippocampal dysfunction ( Mishra et al. 2021 ). However, the question remains regarding its participation in the cerebellum, particularly in relation to TH deficiency. Growth factors have a diverse

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0338
Volume/Issue:
Volume 257: Issue 1
Restricted access
SP Bidey
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DJ Hill
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MC Eggo
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By combining data from studies of multinodular non-toxic goitre (MNTG) with data from rat models of goitre induction and in vitro models, a map of the growth factors involved in goitrogenesis has been constructed. We have addressed the roles of the insulin-like growth factors, transforming growth factors, fibroblast growth factors, endothelins, etc. We hypothesise that an imbalance in the interactions between the various growth factor axes exists in MNTG which favours cell replication. Thyrotrophin, although not significantly elevated in MNTG, exerts critical effects through interactions with autocrine and paracrine factors and their receptors. Expansion of the thyroidal vascular bed through angiogenesis is closely co-ordinated with follicular cell expansion and folliculoneogenesis, and while the integrated paracrine actions of fibroblast growth factors, vascular endothelial growth factor and endothelin probably play central roles, additional, as yet elusive, factors are probably involved. The combination of in vitro and in vivo approaches, designed to address specific questions, will undoubtedly continue to prove invaluable in dissecting further the complex interactions that exist between these growth factors, their binding proteins and receptors in goitrogenesis.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1600321
Volume/Issue:
Volume 160: Issue 3
Free access
A G Kayali Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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A Stotland Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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K V Gunst Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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M Kritzik Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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G Liu Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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S Dabernat Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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Y-Q Zhang Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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W Wu Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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N Sarvetnick Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Laboratoire de Biologie de la Differentation et du Development, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat 33076 Bordeaux cedex, France

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Introduction Transduction of cellular signals is critical for development of mature cells and tissues. The regulation of mitogenesis by growth factors such as epidermal growth factor (EGF), erbB ligands, platelet-derived growth

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05949
Volume/Issue:
Volume 185: Issue 1
Free access
Karen Forbes School of Biomedicine, Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9WL, UK

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Melissa Westwood School of Biomedicine, Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9WL, UK

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circulation, including growth factors, can influence placental development and function ( Baczyk et al . 2005 , Johnstone et al . 2005 b , Sferruzzi-Perri et al . 2006 , 2007, Moll et al . 2007 , Forbes et al . 2008 , 2010 a , b , c , Hoffmann et

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0174
Volume/Issue:
Volume 207: Issue 1
Free access
F A Hills
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M G Elder
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T Chard
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M H F Sullivan
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functions is not well understood, despite the importance of these cells to pregnancy. Very many of the known growth factors and cytokines are expressed at the feto–maternal interface in fetal placenta, or in maternal decidua ( Rice & Chard 1998 ); this also

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05867
Volume/Issue:
Volume 183: Issue 3
Free access
Pongpan Tanajak Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine

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Siriporn C Chattipakorn Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine

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Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine
Cardiac Electrophysiology Research and Training Center, Cardiac Electrophysiology Unit, Center of Excellence in Cardiac Electrophysiology Research, Department of Oral Biology and Diagnostic Sciences, Faculty of Medicine

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Introduction Fibroblast growth factors (FGFs) are polypeptide chains that have paracrine, autocrine or endocrine functions. The paracrine FGFs are further divided into five subfamilies, whereas the autocrine and endocrine FGFs are composed of one

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0289
Volume/Issue:
Volume 227: Issue 2
Free access
Lorena González
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Ma. Eugenia Díaz
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Johanna G Miquet
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Ana I Sotelo
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Diego Fernández Departamento de Química Biológica, Cátedra de Bioquímica Humana, Geriatrics Research, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina

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Fernando P Dominici
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Andrzej Bartke Departamento de Química Biológica, Cátedra de Bioquímica Humana, Geriatrics Research, Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina

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Daniel Turyn
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Introduction The relevance of growth factors to the pathogenesis of human cancer has long been established. Different mechanisms may contribute to amplify the signal driven by growth factors: the overexpression of growth factors or the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0372
Volume/Issue:
Volume 204: Issue 3
Free access