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Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia
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initiating peripheral glucose uptake particularly in muscle and adipose tissue, and repressing glucagon activity. Glucose transporters GLUT1, GLUT2 and GLUT3 (predominantly GLUT1) facilitate glucose uptake in human β-cells. In mouse β-cells, GLUT2 is the
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. 2013 ). Given the health burden associated with reproductive pathology, novel treatments are continually being sought. Studies in animals ( Thompson et al. 2004 ) and humans have consistently shown that kisspeptin stimulates gonadotrophin secretion
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hypothalamic areas ( Bittencourt et al. 1992 , Sita et al. 2007 , Bittencourt 2011 ). Mch / MCH and MCH have also been reported in rodent and human peripheral tissue ( Hervieu & Nahon 1995 , Verlaet et al. 2002 , Sandig et al. 2007 ). Circulating
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Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
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Department of Obstetrics, The Second Hospital of Shandong University, Jinan, Shandong, People’s Republic of China
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was previously identified in human luteinized granulosa cells (hGCs) by microarray and PCR analyses ( Skiadas et al. 2012 , Kranc et al. 2017 ) and that STARD6 mRNA is highly expressed in the functional porcine corpus luteum, we asked whether
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previously that ganitumab, a fully human MAB to IGF1R, inhibits the activation of human IGF1R and IGF1R–insulin receptor (IR) hybrids without cross-reacting with the IR ( Beltran et al . 2009 , 2011 ). In addition, we have demonstrated that targeting a
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
INSERM U1138, University Paris Descartes, University Pierre and Marie Curie, Diabetology, INSERM U695, Paris Diderot University, Department of Endocrinology, Institut inter Régional Pour la Santé, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006 Paris, France
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al . 1998 , Beard et al . 2006 ). However, in humans, the effect of kinins on muscle glucose uptake remains controversial ( Dietze et al . 1996 , Nuutila et al . 1996 , Mahajan et al . 2004 ). Although clinical and experimental studies have
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WAT, in male mice also called epididymal WAT) and subcutaneously close to the hind limbs (inguinal WAT) ( Bartelt & Heeren 2014 ). In humans, the major sites of WAT are under the skin (subcutaneous WAT) and associated with the digestive tract (visceral
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folliculogenesis. The molecular pathways involved in the luteinisation of granulosa cells are not entirely clear. While the luteinising hormone (LH) surge or addition of LH or human chorionic gonadotrophin (hCG) initiate luteinisation, experimental work clearly
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy
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Introduction The human endometrium expresses several peptides/proteins that are believed to participate in the paracrine signaling to other cell types during the menstrual cycle and in early pregnancy, and dysfunction in synthesis
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, we extend those findings and show yapsin 1-like immunoreactivity exclusively in human pancreatic islet α-cells and that purified yapsin 1 can generate glucagon by processing proglucagon. These results suggest the presence of a yapsin 1-like