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Ana María Pino Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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Juan Manuel Rodríguez Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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Susana Ríos Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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Pablo Astudillo Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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Laura Leiva Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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Germán Seitz Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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Mireya Fernández Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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J Pablo Rodríguez Laboratorio de Biología Celular, INTA, Universidad de Chile, El Líbano 5524, Macul. Casilla 138-11, Santiago, Chile
Laboratorio de Envejecimiento y Enfermedades Crónicas Relacionadas con la Nutrición, INTA, Universidad de Chile, Santiago, Chile
Servicio de Traumatología, Hospital Sótero del Río, Santiago, Chile

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endocrine system. Endocrine Reviews 16 200 –257. Bruder SP , Jaiswal N & Haynesworth SE 1997 Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive

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Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Raj K Mishra SIPS Superspeciality Hospital, Lucknow, Uttar Pradesh, India

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Zakir Hussain Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Jiaur R Gayen Division of Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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Anil N Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India

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protein is shown adjacent to the blots, n =3, error bars represent s.d. , * P <0.05, *** P <0.001 as compared by Student’s t- test (H). Human mesenchymal stem cell are known to differentiate into white and brown adipocytes; recently, Elabd and

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Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Ganesh Panzade Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Rajesh Pandey CSIR Ayurgenomics Unit-TRISUTRA, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Sanchita Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Raj Kumar Mishra SIPS Superspeciality Hospital, Lucknow, India

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Ravi Shankar Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Anil Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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diabetes. Materials and methods hMSC culture and differentiation into white and brown adipocytes Human mesenchymal stem cell (hMSC) was cultured in high-glucose DMEM supplemented with 10% fetal bovine serum (Gibco) and 1% antibiotics. hMSC was

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S Benvenuti
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P Luciani
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I Cellai
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C Deledda
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S Baglioni
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R Saccardi Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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S Urbani Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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F Francini Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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R Squecco Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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C Giuliani
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G B Vannelli Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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M Serio
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A Pinchera Endocrine Unit, Department of Haematology, Anatomy, Section of Endocrinology, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies’ (DENOThe), University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy

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A Peri
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demonstrated that high levels of expression of seladin-1 were detectable in human mesenchymal stem cells (hMSC), whereas a significant reduction was observed in hMSC-derived neurons (hMSC-n; Benvenuti et al . 2006 ). We have also detected high levels of

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Emin Umit Bagriacik Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey
Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Melek Yaman Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Rauf Haznedar Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Gulsan Sucak Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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Tuncay Delibasi Immunology Research Center, Department of Immunology, Department of Hematology, Endocrinology Department, Gazi University, 06500 Ankara, Turkey

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experimental system, we plan to design in vivo studies in the future. In conclusion, this study has provided novel information regarding the regulatory role of neuroendocrine interactions of the hypothalamic–pituitary axis in human mesenchymal stem cell

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Amy Hughes Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA

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Darling Rojas-Canales Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA

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Chris Drogemuller Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA

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Nicolas H Voelcker Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA

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Shane T Grey Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA

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P T H Coates Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA

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group showed that IGF1 releasing silk fibroin scaffolds initiated chondrogenesis from human mesenchymal stem cells in vitro ( Uebersax et al . 2008 ). Adsorbing IGF1 onto porous hydroxyapatite, or chitosan scaffolds, enhanced osseointegration in vivo

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Nicoleta C Olarescu Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Darlene E Berryman Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Lara A Householder Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Ellen R Lubbers Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Edward O List Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Fabian Benencia Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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John J Kopchick Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Jens Bollerslev Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway

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Multilineage potential of adult human mesenchymal stem cells . Science 284 143 – 147 . ( doi:10.1126/science.284.5411.143 ) Reinisch A Etchart N Thomas D Hofmann NA Fruehwirth M Sinha S Chan CK Senarath-Yapa K Seo E Wearda T 2014

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Fan He School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Xiaozhen Liu School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Ke Xiong School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Sijin Chen School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Long Zhou School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Wenguo Cui School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Guoqing Pan School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Zong-Ping Luo School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China
School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Ming Pei School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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Yihong Gong School of Engineering, Orthopaedic Institute, Department of Orthopaedics, Nanfang Hospital, Stem Cell and Tissue Engineering Laboratory, Sun Yat-sen University, No. 132 East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, China

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human mesenchymal stem cells . Journal of Pineal Research 55 14 – 25 . ( doi:10.1111/jpi.12045 ) Liu X Xu Y Chen S Tan Z Xiong K Li Y Ye Y Luo ZP He F Gong Y 2014 Rescue of proinflammatory cytokine-inhibited chondrogenesis by

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Xiwen Xiong Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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Xupeng Sun Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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Qingzhi Wang Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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Xinlai Qian Department of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China

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Yang Zhang Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Xiaoyan Pan Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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X Charlie Dong Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA

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of PA-induced β-cell dysfunction and apoptosis ( Janikiewicz et al . 2015 ). A recent report has shown that SIRT6 can protect human mesenchymal stem cells from oxidative stress through regulation of nuclear factor erythroid 2-related factor 2 (NRF2

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Majdi Masarwi Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Felsenstein Medical Research Center, Petach Tikva, Israel

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Raanan Shamir Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Felsenstein Medical Research Center, Petach Tikva, Israel
Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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Moshe Phillip Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Felsenstein Medical Research Center, Petach Tikva, Israel
The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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Galia Gat-Yablonski Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Felsenstein Medical Research Center, Petach Tikva, Israel
The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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expression was reported in human mesenchymal stem cells of bone marrow ( Heim et al . 2004 ) which can differentiate into osteoblasts, adipocytes and chondrocytes ( Pittenger et al . 1999 ). Leptin plus vitamin D 1,25(OH) 2 D 3 stimulated aromatase

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