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Irene Andrés-Blasco, Andrea Herrero-Cervera, Ángela Vinué, Sergio Martínez-Hervás, Laura Piqueras, María Jesús Sanz, Deborah Jane Burks, and Herminia González-Navarro

glucose metabolism, hepatic steatosis, pancreatic characteristics and the associated inflammation were analysed. Materials and methods Mice and diets Animal care was in accordance with institutional guidelines and the 2010/63/EU directive from the European

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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

increased mortality not only from vascular disease but also from complications of cirrhosis and hepatocellular cancer. Thus, targeting hepatocellular inflammation is expected to significantly prevent the progression of the disease and reduce mortality in

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Bo-Kyung Son, Taro Kojima, Sumito Ogawa, and Masahiro Akishita

presumed to be due, in part, to lack of a reliable animal model. Because inflammation is a hallmark of AAA, we induced an inflammatory AAA murine model in wild-type mice by modification of our previous finding ( Son et al. 2015 ). Using this AAA model

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Natasha Singh, Bronwen Herbert, Gavin R Sooranna, Nicolas M Orsi, Lydia Edey, Tathagata Dasgupta, Suren R Sooranna, Steven M Yellon, and Mark R Johnson

assertion made by the WHO that no progress will be made in the management of preterm labour until we understand the processes involved in human labour. Myometrial inflammation is held to play a key role in the onset of labour, repressing progesterone

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Yingxin Xian, Zonglan Chen, Hongrong Deng, Mengyin Cai, Hua Liang, Wen Xu, Jianping Weng, and Fen Xu

Introduction Obesity is widely considered as a state with low-grade chronic inflammation ( de Heredia et al. 2012 ). Elevated circulating levels of inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6

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James C Needell, Madalyn N Brown, and Danny Zipris

inflammation and hyperglycemia (this manuscript). Because microbes can directly infect adipocytes and induce systemic inflammation and metabolic dysregulation ( Schäffler & Schölmerich 2010 ), and given the well-established link between adipose tissue

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Mingjuan Deng, Fang Qu, Long Chen, Chang Liu, Ming Zhang, Fazheng Ren, Huiyuan Guo, Hao Zhang, Shaoyang Ge, Chaodong Wu, and Liang Zhao

inflammation ( Yamashita et al . 2007 , den Besten et al . 2015 , Jin et al . 2015 ). Indeed, SCFAs, mainly acetate, propionate, and butyrate, are not only metabolic substrates, but also signaling molecules that regulate metabolism ( Koh et al . 2016

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Salla Nuutinen, Liisa Ailanen, Eriika Savontaus, and Petteri Rinne

the alleviation of inflammation stems from the inhibition of nuclear factor kappa B-driven inflammation ( Manna & Aggarwal 1998 , Yang et al. 2015 ). Melanocortin activation reduces the expression of proinflammatory cytokines, their receptors and

Open access

Farhana Naznin, Koji Toshinai, T M Zaved Waise, Cherl NamKoong, Abu Saleh Md Moin, Hideyuki Sakoda, and Masamitsu Nakazato

mice ( Briggs et al . 2010 ). However, the mechanism underlying this unresponsiveness remains to be demonstrated. Immune-cell-mediated tissue inflammation in the adipose tissue, liver, and skeletal muscle plays a critical role in the development of

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You-Hua Xu, Chen-Lin Gao, Heng-Li Guo, Wen-Qian Zhang, Wei Huang, Shan-Shan Tang, Wen-Jun Gan, Yong Xu, Hua Zhou, and Quan Zhu

Introduction Type 2 diabetes mellitus (T2DM) has been recognized as an epidemic disease with low-grade chronic inflammation as its pivotal characteristic. Epidemiological studies show that inflammatory cytokines and LPS dramatically elevated