glucose metabolism, hepatic steatosis, pancreatic characteristics and the associated inflammation were analysed. Materials and methods Mice and diets Animal care was in accordance with institutional guidelines and the 2010/63/EU directive from the European
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Irene Andrés-Blasco, Andrea Herrero-Cervera, Ángela Vinué, Sergio Martínez-Hervás, Laura Piqueras, María Jesús Sanz, Deborah Jane Burks, and Herminia González-Navarro
Mari van de Vyver
Introduction Inflammation is part of the body’s innate immune response and is an essential process that not only defends against harmful bacteria and pathogens but also plays a key role in the maintenance and repair of tissues. It is mediated
Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall
increased mortality not only from vascular disease but also from complications of cirrhosis and hepatocellular cancer. Thus, targeting hepatocellular inflammation is expected to significantly prevent the progression of the disease and reduce mortality in
Bo-Kyung Son, Taro Kojima, Sumito Ogawa, and Masahiro Akishita
presumed to be due, in part, to lack of a reliable animal model. Because inflammation is a hallmark of AAA, we induced an inflammatory AAA murine model in wild-type mice by modification of our previous finding ( Son et al. 2015 ). Using this AAA model
Natasha Singh, Bronwen Herbert, Gavin R Sooranna, Nicolas M Orsi, Lydia Edey, Tathagata Dasgupta, Suren R Sooranna, Steven M Yellon, and Mark R Johnson
assertion made by the WHO that no progress will be made in the management of preterm labour until we understand the processes involved in human labour. Myometrial inflammation is held to play a key role in the onset of labour, repressing progesterone
Leke Wiering and Frank Tacke
Metabolic injury and hepatocytes There are several intra- as well as extrahepatic triggers for inflammation in NASH that relate to the metabolic injury to the liver ( Schuster et al. 2018 ). While this review does not aim to provide a detailed overview
Yingxin Xian, Zonglan Chen, Hongrong Deng, Mengyin Cai, Hua Liang, Wen Xu, Jianping Weng, and Fen Xu
Introduction Obesity is widely considered as a state with low-grade chronic inflammation ( de Heredia et al. 2012 ). Elevated circulating levels of inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6
James C Needell, Madalyn N Brown, and Danny Zipris
inflammation and hyperglycemia (this manuscript). Because microbes can directly infect adipocytes and induce systemic inflammation and metabolic dysregulation ( Schäffler & Schölmerich 2010 ), and given the well-established link between adipose tissue
Mingjuan Deng, Fang Qu, Long Chen, Chang Liu, Ming Zhang, Fazheng Ren, Huiyuan Guo, Hao Zhang, Shaoyang Ge, Chaodong Wu, and Liang Zhao
inflammation ( Yamashita et al . 2007 , den Besten et al . 2015 , Jin et al . 2015 ). Indeed, SCFAs, mainly acetate, propionate, and butyrate, are not only metabolic substrates, but also signaling molecules that regulate metabolism ( Koh et al . 2016
Salla Nuutinen, Liisa Ailanen, Eriika Savontaus, and Petteri Rinne
the alleviation of inflammation stems from the inhibition of nuclear factor kappa B-driven inflammation ( Manna & Aggarwal 1998 , Yang et al. 2015 ). Melanocortin activation reduces the expression of proinflammatory cytokines, their receptors and
