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Sandra Pereira, Anu Shah, I George Fantus, Jamie W Joseph and Adria Giacca

Introduction Obesity is associated with elevated circulating free fatty acids (FFAs) and FFAs cause insulin resistance ( Lewis et al . 2002 , Xiao et al . 2008 ). FFAs induce oxidative stress ( Nakamura et al . 2009 , Yuzefovych et al . 2010

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Gary J Remington, Celine Teo, Virginia Wilson, Araba Chintoh, Melanie Guenette, Zohra Ahsan, Adria Giacca and Margaret K Hahn

point, to our knowledge, only two clinical studies exist specifically evaluating insulin resistance or impaired glucose tolerance respectively in the context of antipsychotic treatment ( Henderson et al . 2009 , Smith et al . 2013 ). Both examined

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Mohamed Asrih and François R Jornayvaz

, insulin resistance, hypertension, and dyslipidemia, suggesting that NAFLD might be considered as the liver manifestation of the metabolic syndrome ( Marchesini et al . 2001 , Adams et al . 2005 ). The metabolic syndrome is a leading cause of mortality

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Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr and Brant R Burkhardt

. 2 A. The difference in fasting glycemia was diminished over time due to WT group (6 months of age) having increased glucose levels potentially attributed to age-dependent insulin resistance ( Fig. 2 A). Significantly higher ( P <0.001) glycemic

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Xiao-Bing Cui, Jun-Na Luan, Jianping Ye and Shi-You Chen

, and metabolic energy balance ( Chatterjee et al . 2014 ). Although the underlying mechanism is not fully understood, adipose tissue inflammation has been acknowledged as a critical link between obesity and insulin resistance and type 2 diabetes, and

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João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak and François R Jornayvaz

, is affecting about one out of three individuals ( Williams et al . 2011 ). NAFLD is a major risk factor in the development of insulin resistance and type 2 diabetes ( Angulo 2002 , Fabbrini et al . 2010 , Asrih & Jornayvaz 2015 ). Fibroblast

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Rubén Marín-Juez, Susanne Jong-Raadsen, Shuxin Yang and Herman P Spaink

insulin resistance in mammals. For instance, a twofold increase in plasma insulin levels can induce insulin resistance in mice, resembling the pattern in insulin-resistant patients with pathological obesity or type 2 diabetes who show similar increases in

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Hamza Amine, Yacir Benomar, Adil Haimeur, Hafida Messaouri, Nadia Meskini and Mohammed Taouis

Introduction Insulin resistance is a major risk factor for type 2 diabetes that is often associated with metabolic syndrome including obesity, cardiovascular diseases and dyslipidemia. The alarming worldwide augmentation of type 2 diabetes becomes a

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Min Kyong Moon, In-Kyong Jeong, Tae Jung Oh, Hwa Young Ahn, Hwan Hee Kim, Young Joo Park, Hak Chul Jang and Kyong Soo Park

, Shankar & Teppala 2011 ), cardiovascular disease ( Lang et al . 2008 ), obesity, and insulin resistance ( Wang et al . 2012 ). Several possible mechanisms have been suggested by animal and in vitro studies, yet whether BPA causes insulin resistance or

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Sergio Di Meo, Susanna Iossa and Paola Venditti

increased the most in obese people, compared with lean ones, is type 2 diabetes mellitus (T2DM), a condition resulting from the metabolic changes associated with excess fat. A pivotal role in T2DM development is played by insulin resistance (IR) that is