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Jiean Xu, Qiuhua Yang, Xiaoyu Zhang, Zhiping Liu, Yapeng Cao, Lina Wang, Yaqi Zhou, Xianqiu Zeng, Qian Ma, Yiming Xu, Yong Wang, Lei Huang, Zhen Han, Tao Wang, David Stepp, Zsolt Bagi, Chaodong Wu, Mei Hong, and Yuqing Huo

resistance-associated metabolic perturbations. Accumulating evidence highlights a critical role for adenosine signaling in the development of insulin resistance ( Antonioli et al. 2015 , Pardo et al. 2017 ). Adenosine signaling is also closely

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Sandra Pereira, Anu Shah, I George Fantus, Jamie W Joseph, and Adria Giacca

Introduction Obesity is associated with elevated circulating free fatty acids (FFAs) and FFAs cause insulin resistance ( Lewis et al . 2002 , Xiao et al . 2008 ). FFAs induce oxidative stress ( Nakamura et al . 2009 , Yuzefovych et al . 2010

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Mohamed Asrih and François R Jornayvaz

, insulin resistance, hypertension, and dyslipidemia, suggesting that NAFLD might be considered as the liver manifestation of the metabolic syndrome ( Marchesini et al . 2001 , Adams et al . 2005 ). The metabolic syndrome is a leading cause of mortality

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Yujiao Dai, Peng Hao, Zhimei Sun, Zhiyi Guo, Hong Xu, Lihui Xue, Hongyu Song, Yida Li, Shuang Li, Mingming Gao, Teng Si, Yuxin Zhang, and Yajuan Qi

reverse its progression. However, if Yap is involved in liver fibrosis induced by insulin resistance (IR) has not been reported. In this study, mouse liver fibrosis was induced by IR using HFD stimulation, and the liver YAP pathway and insulin pathway

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Gary J Remington, Celine Teo, Virginia Wilson, Araba Chintoh, Melanie Guenette, Zohra Ahsan, Adria Giacca, and Margaret K Hahn

point, to our knowledge, only two clinical studies exist specifically evaluating insulin resistance or impaired glucose tolerance respectively in the context of antipsychotic treatment ( Henderson et al . 2009 , Smith et al . 2013 ). Both examined

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Xiao-Bing Cui, Jun-Na Luan, Jianping Ye, and Shi-You Chen

, and metabolic energy balance ( Chatterjee et al . 2014 ). Although the underlying mechanism is not fully understood, adipose tissue inflammation has been acknowledged as a critical link between obesity and insulin resistance and type 2 diabetes, and

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Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr, and Brant R Burkhardt

. 2 A. The difference in fasting glycemia was diminished over time due to WT group (6 months of age) having increased glucose levels potentially attributed to age-dependent insulin resistance ( Fig. 2 A). Significantly higher ( P <0.001) glycemic

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Baiyang You, Yaoshan Dun, Wenliang Zhang, Lingjun Jiang, Hui Li, Murong Xie, Yuan Liu, and Suixin Liu

Introduction Insulin resistance (IR) is characterized by the reduction of insulin-stimulated glucose uptake and disposal in insulin target tissues including skeletal muscle, the liver, the heart and the adipose, which could be responsible for

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João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak, and François R Jornayvaz

, is affecting about one out of three individuals ( Williams et al . 2011 ). NAFLD is a major risk factor in the development of insulin resistance and type 2 diabetes ( Angulo 2002 , Fabbrini et al . 2010 , Asrih & Jornayvaz 2015 ). Fibroblast

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Rubén Marín-Juez, Susanne Jong-Raadsen, Shuxin Yang, and Herman P Spaink

insulin resistance in mammals. For instance, a twofold increase in plasma insulin levels can induce insulin resistance in mice, resembling the pattern in insulin-resistant patients with pathological obesity or type 2 diabetes who show similar increases in