Search Results

You are looking at 1 - 10 of 1,091 items for :

  • "insulin resistance" x
  • Refine by Access: All content x
Clear All
Free access

Amanda J Genders, Jujiao Kuang, Evelyn C Marin, Nicholas J Saner, Javier Botella, Macsue Jacques, Glenn K McConell, Victor A Andrade-Souza, Javier Chagolla, and David J Bishop

Introduction Patients with insulin resistance have been reported to have decreased skeletal muscle mitochondrial content ( Kelley et al. 2002 , Ritov et al. 2005 , Chomentowski et al. 2011 ) and reductions in skeletal muscle

Free access

Sandra Pereira, Anu Shah, I George Fantus, Jamie W Joseph, and Adria Giacca

Introduction Obesity is associated with elevated circulating free fatty acids (FFAs) and FFAs cause insulin resistance ( Lewis et al . 2002 , Xiao et al . 2008 ). FFAs induce oxidative stress ( Nakamura et al . 2009 , Yuzefovych et al . 2010

Free access

Jiean Xu, Qiuhua Yang, Xiaoyu Zhang, Zhiping Liu, Yapeng Cao, Lina Wang, Yaqi Zhou, Xianqiu Zeng, Qian Ma, Yiming Xu, Yong Wang, Lei Huang, Zhen Han, Tao Wang, David Stepp, Zsolt Bagi, Chaodong Wu, Mei Hong, and Yuqing Huo

resistance-associated metabolic perturbations. Accumulating evidence highlights a critical role for adenosine signaling in the development of insulin resistance ( Antonioli et al. 2015 , Pardo et al. 2017 ). Adenosine signaling is also closely

Free access

Mohamed Asrih and François R Jornayvaz

, insulin resistance, hypertension, and dyslipidemia, suggesting that NAFLD might be considered as the liver manifestation of the metabolic syndrome ( Marchesini et al . 2001 , Adams et al . 2005 ). The metabolic syndrome is a leading cause of mortality

Free access

Yujiao Dai, Peng Hao, Zhimei Sun, Zhiyi Guo, Hong Xu, Lihui Xue, Hongyu Song, Yida Li, Shuang Li, Mingming Gao, Teng Si, Yuxin Zhang, and Yajuan Qi

reverse its progression. However, if Yap is involved in liver fibrosis induced by insulin resistance (IR) has not been reported. In this study, mouse liver fibrosis was induced by IR using HFD stimulation, and the liver YAP pathway and insulin pathway

Free access

Xiao-Bing Cui, Jun-Na Luan, Jianping Ye, and Shi-You Chen

, and metabolic energy balance ( Chatterjee et al . 2014 ). Although the underlying mechanism is not fully understood, adipose tissue inflammation has been acknowledged as a critical link between obesity and insulin resistance and type 2 diabetes, and

Free access

Qiuhua Yang, Jiean Xu, Qian Ma, Zhiping Liu, Yaqi Zhou, Yongfeng Cai, Xiaoxiao Mao, David Stepp, Neal Weintraub, David J Fulton, Mei Hong, and Yuqing Huo

-fat diet (HFD)-induced insulin resistance. Saturated fatty acids are major contributors to the process of high-fat feeding, causing insulin resistance ( Nakamura et al. 2009 ). It has been well demonstrated that palmitate induces inflammation in

Free access

Gary J Remington, Celine Teo, Virginia Wilson, Araba Chintoh, Melanie Guenette, Zohra Ahsan, Adria Giacca, and Margaret K Hahn

point, to our knowledge, only two clinical studies exist specifically evaluating insulin resistance or impaired glucose tolerance respectively in the context of antipsychotic treatment ( Henderson et al . 2009 , Smith et al . 2013 ). Both examined

Free access

João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak, and François R Jornayvaz

, is affecting about one out of three individuals ( Williams et al . 2011 ). NAFLD is a major risk factor in the development of insulin resistance and type 2 diabetes ( Angulo 2002 , Fabbrini et al . 2010 , Asrih & Jornayvaz 2015 ). Fibroblast

Free access

Rubén Marín-Juez, Susanne Jong-Raadsen, Shuxin Yang, and Herman P Spaink

insulin resistance in mammals. For instance, a twofold increase in plasma insulin levels can induce insulin resistance in mice, resembling the pattern in insulin-resistant patients with pathological obesity or type 2 diabetes who show similar increases in