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Adam Gesing Department of Internal Medicine, Department of Oncological Endocrinology, Burnett School of Biomedical Sciences, Institute of Human Genetics, Geriatrics Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, Illinois 62794-9628, USA
Department of Internal Medicine, Department of Oncological Endocrinology, Burnett School of Biomedical Sciences, Institute of Human Genetics, Geriatrics Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, Illinois 62794-9628, USA

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Andrzej Bartke Department of Internal Medicine, Department of Oncological Endocrinology, Burnett School of Biomedical Sciences, Institute of Human Genetics, Geriatrics Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, Illinois 62794-9628, USA

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Michal M Masternak Department of Internal Medicine, Department of Oncological Endocrinology, Burnett School of Biomedical Sciences, Institute of Human Genetics, Geriatrics Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, Illinois 62794-9628, USA
Department of Internal Medicine, Department of Oncological Endocrinology, Burnett School of Biomedical Sciences, Institute of Human Genetics, Geriatrics Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, Illinois 62794-9628, USA

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cardiovascular events ( Lincoff et al . 2007 ). The aim of the study was to analyze the effects of PIO on the insulin-signaling pathway (hepatic levels of insulin receptor (IR), insulin receptor substrate-1 (IRS1) – total and phosphorylated at a serine(307

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0124
Volume/Issue:
Volume 219: Issue 2
Free access
Young Hoon Son Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Seok-Jin Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Ki-Baek Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Jin-Haeng Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Eui Man Jeong Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea
Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Sun Gun Chung Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Sang-Chul Park Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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In-Gyu Kim Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea
Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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hypertriglyceridemia ( Gazzerro et al . 2010 ). Moreover, we have demonstrated that the level of CAV1 in skeletal muscle is related to insulin sensitivity in vitro and in vivo ( Oh et al . 2008 ), indicating that CAV1 may regulate insulin signaling. Notably, Cav

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0490
Volume/Issue:
Volume 225: Issue 1
Open access
Bruno C Pereira Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Alisson L da Rocha Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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Ana P Pinto Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil

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José R Pauli Sport Sciences Course, Faculty of Applied Sciences, State University of Campinas, Limeira, São Paulo, Brazil

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Leandro P de Moura Sport Sciences Course, Faculty of Applied Sciences, State University of Campinas, Limeira, São Paulo, Brazil

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Rania A Mekary Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Department of Social and Administrative Sciences, MCPHS University, Boston, Massachusetts, USA

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Ellen C de Freitas School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

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Adelino S R da Silva Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, Ribeirão Preto, São Paulo, Brazil
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

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& Kahn 1994 , Cheatham & Kahn 1995 , Virkamaki et al . 1999 ). A growing body of evidence suggests that the phosphorylation of IRS1 at serine 307 is directly linked to the molecular mechanism responsible of the impairment of insulin signaling pathway

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0063
Volume/Issue:
Volume 230: Issue 1
Free access
Melanie Tran Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Golam Mostofa Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Michael Picard Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Jianguo Wu Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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Li Wang Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

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Dong-Ju Shin Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA

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using a glucometer before (0) and after glucose or insulin injection at 5, 10, 15, 30, 60, 90, and 120 min. The glucose area under curve (AUC) for the GTT and ITT was calculated using GraphPad Prism software. To assess insulin signaling in liver and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0073
Volume/Issue:
Volume 256: Issue 3
Restricted access
A Tsuchiya Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

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T Kanno Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

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T Nishizaki Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

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kinase 1 (Pak1; Mao et al . 2008 ), in a PI3K-independent manner. This study was conducted to gain further insight into PI3K-induced Akt activation in the insulin signal transduction pathway. To address this, we monitored GLUT4 mobilizations, measured

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0172
Volume/Issue:
Volume 220: Issue 1
Open access
Sojin Lee Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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H Henry Dong Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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, kidney, muscle and adipose tissues, a broad tissue distribution that is characteristic of other FoxO isoforms in mammals ( Kim et al. 2011 ). Recent studies indicate that FoxO6 plays important roles in integrating insulin signaling to glucose and lipid

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0002
Volume/Issue:
Volume 233: Issue 2
Free access
Medha Sharma Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India

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Yamini Yadav Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India

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Chinmoy Sankar Dey Kusuma School of Biological Sciences, Indian Institute of Technology, Delhi, New Delhi, India

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Introduction Insulin signaling is the principal pathway that regulates glucose homeostasis of the body. Insulin binds to insulin receptor (IR) and initiates a complex signaling cascade, leading to glucose transporter type 4 (GLUT4

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0151
Volume/Issue:
Volume 260: Issue 1
Restricted access
María Florencia Heber Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

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Silvana Rocío Ferreira Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

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Giselle Adriana Abruzzese Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

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Raíces Trinidad Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental – CONICET, Buenos Aires, Argentina

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Omar P Pignataro Laboratorio de Endocrinología Molecular y Transducción de Señales, Instituto de Biología y Medicina Experimental – CONICET, Buenos Aires, Argentina

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Margarita Vega Laboratorio de Endocrinología y Biología Reproductiva, Hospital Clínico Universidad de Chile, Independencia, Santiago de Chile, Chile

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Alicia B Motta Laboratorio de Fisio-patología Ovárica, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

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metabolic action ( Rincon et al. 1996 , Diamanti-Kandarakis & Dunaif 2012 ). It has been proposed that insulin resistance is caused by a post-binding defect in the insulin signaling pathway and/or related to mutations in the insulin receptor ( IR ) gene

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0520
Volume/Issue:
Volume 240: Issue 3
Free access
Mi-Hyun Kim
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Jae-Hwan Jee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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Sunyoung Park
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Myung-Shik Lee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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Kwang-Won Kim Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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Moon-Kyu Lee Division of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, Samsung Biomedical Research Institute, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea

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-dependent degradation of β-catenin ( Yi et al . 2008 ). Furthermore, in human hepatocytes, granulosa cells, and C2C12 myotubes, metformin quickly leads to insulin receptor phosphorylation and enhances insulin signaling, e.g., phosphoinositide 3 kinase (PI3K), both in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0381
Volume/Issue:
Volume 220: Issue 2
Free access
Hong Ma Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
Medical College, Nantong University, Nantong, Jiangsu Province, China

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Jin Yuan Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

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Jinyu Ma Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, Jiangsu Province, China

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Jie Ding Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, Jiangsu Province, China

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Weiwei Lin Department of Histology and Embryology, Medical College, Nantong University, Nantong, Jiangsu Province, China

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Xinlei Wang Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

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Mingliang Zhang Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, Jiangsu Province, China

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Yi Sun Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
Medical College, Nantong University, Nantong, Jiangsu Province, China

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Runze Wu Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
Medical College, Nantong University, Nantong, Jiangsu Province, China

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Chun Liu Laboratory Animal Center of Nantong University, Nantong, Jiangsu Province, China

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Cheng Sun Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, Jiangsu Province, China

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Yunjuan Gu Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China

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deletion of BMP7 receptor type 1A in adipose tissue attenuates age-related onset of insulin resistance ( Schulz et al. 2016 ). Thus, it is still unclear whether and how BMP7 regulates insulin signal transduction in the liver. In this study, we increased

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0693
Volume/Issue:
Volume 243: Issue 2
Restricted access