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. 2014 ). Among the hormones known to mediate these effects, the growth hormone (Gh)/insulin-like growth factor 1 (Igf1) axis is one of the most-studied regulators of osmoregulation in fish gill response to salinity stress. Gh/Igf1, considered as an SW
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DWH 1993 Hyaluronic activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-a-dependent mechanism in murine macrophages . Journal of Clinical Investigation 91 2368 – 2377 . Nyman T Pekonen F 1993
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
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2020 Implications of insulin-like growth factor-1 in skeletal muscle and various diseases . Cells 9 1773 . ( https://doi.org/10.3390/cells9081773 ) Backeljauw PF Miller BS Dutailly P Houchard A Lawson E Hale DE Reiner B Sperling MA
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
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Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
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Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
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Dhamija Y Kidd M Le LD King A Shaaban A Crombleholme TM 2014 Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis . Journal of Surgical Research 190 367 – 377 . ( https://doi.org/10
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ABSTRACT
The relationship between plasma GH profiles and circulating concentrations of insulin-like growth factor 1 (IGF-1) at three different planes of nutrition, chosen to represent a high, medium and low level of nutrition (3%, 1·8% and 1% dry matter of liveweight per day) was studied in 15 young Angus steers. All steers were maintained on 3% dry matter for 5 weeks, then on one of the three nutritional planes for 4 weeks and then all were returned to 3% dry matter for 3 weeks. Blood was sampled through jugular catheters at 15-min intervals for 25 h at the end of each phase of the study and additional samples were taken on 2 days each week.
Pulsatile release of GH occurred episodically with a diurnal increase during night and morning hours only in steers on high nutritional intakes. Reduced feeding at both the medium and the low plane abolished the diurnal rhythm and significantly increased mean plasma GH concentrations, the amplitude of GH pulses and the area under the GH profiles. Baseline concentrations of GH and pulse frequency did not change through nutritional manipulation. Upon realimentation, plasma GH concentrations decreased in both previously undernourished groups, with those fed 1% dry matter still having increased levels 10 days after refeeding. Plasma IGF-1 concentrations showed no periodicity. With nutritional deprivation, a decrease in IGF-1 concentration was observed only at negative energy balance (1% group). In this group plasma IGF-1 concentrations were progressively restored within 1 week of realimentation.
The different relationship between GH and IGF-1 release at each plane of nutrition suggests that at both medium and low levels of feed intake, tissue insensitivity to GH may exist peripherally and perhaps centrally. It is suggested that nutritional status may, through modulation of tissue sensitivity to GH, be a primary factor in determining growth and the regulation of the somatotrophic axis in the postnatal ruminant.
J. Endocr. (1986) 111, 209–215
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Introduction Insulin-like growth factor 1 (IGF-1) is a critical fetal growth hormone. Fetal and umbilical cord concentrations of IGF-1 have a strong, positive correlation with birth weight ( Gluckman et al. 1983 , Lassarre et al. 1991
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themselves hormone-dependent, and are directly or indirectly controlled by factors such as growth hormone (GH), insulin-like growth factor 1 (IGF1), thyroid hormones and steroids; and in particular, the glucocorticoid hormones that govern hepatic
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Department of Pharmacology and Therapeutics, Department of Obstetrics and Gynecology, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir-William-Osler, Room 104, Montréal, Québec, Canada H3G 1Y6
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Androgens are the primary regulators of epididymal structure and functions. In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates the transcription of target genes. In this study, we demonstrate that in epididymal cells, 5α-dihydrotestosterone (DHT) can cause an alternative and rapid response that is independent of AR–DNA interactions and is mediated by activation of signaling pathways through the AR. We examined changes in AKT and extracellular signal-regulated protein kinases (ERK1/2) activation at early time points after DHT supplementation in the mouse proximal caput epididymis-1 cell line. DHT had no significant effect on AKT activation at any time point. However, DHT activated the ERK pathway as early as at 1 min, the pathway remained activated at 10 min, but activation was not sustained at later time points. Interestingly, ERK activation was blocked by hydroxyflutamide (HF), indicating that early ERK activation was an AR-mediated response. DHT phosphorylates steroid receptor co-activator (SRC) kinase, and this activation was required for the ERK response. EGFR and IGF1R were downstream of SRC, and these two receptors together contributed to enhance ERK and cAMP response element-binding protein (CREB) phosphorylation. We postulate that this rapid action of androgen may ultimately act to modulate the transcription of genes regulated by AR in the nucleus. These results support the hypothesis that DHT can activate a pathway involving the sequential activation of MEK, ERK1/2, and CREB through the EGFR/IGF1R in an epididymal cell line.
School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
Department of Biology, Laurentian University, Ontario, Canada
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School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
Health Sciences North Research Institute, Sudbury, Ontario, Canada
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Department of Chemistry and Biochemistry, Laurentian University, Ontario, Canada
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School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
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School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada
Health Sciences North Research Institute, Sudbury, Ontario, Canada
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Department of Biology, Laurentian University, Ontario, Canada
Department of Biology, York University, Toronto, Ontario, Canada
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.1097/GME.0000000000000921 ) Quesada A Romeo HE Micevych P 2007 Distribution and localization patterns of estrogen receptor-beta and insulin-like growth factor-1 receptors in neurons and glial cells of the female rat substantia nigra: localization
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Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
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Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China
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insulin-like growth factor 1 (IGF1), which not only can participate in the activation of primordial follicles and regulate the number of apoptotic follicles but can also alter the expression levels of steroidogenic enzymes through triggering the
