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fetuses also are characterized by impaired glucose stimulated insulin secretion (GSIS; Nicolini et al. 1990 ). In cases of severe IUGR, fetuses have smaller and less vascularized pancreatic islets with fewer β-cells ( Van Assche et al. 1977 ). This
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BioRender.com. The rationale for the JDRF–DiabetesUK–INNODIA–nPOD symposium entitled ‘Islet cells in human T1D: from recent advances to novel therapies’, which took place in Stockholm, Sweden, between September 23 and 25, 2022, was provided by the
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implication that oestrogen acts as a protective factor for pancreatic islet beta cells to help prevent development of T2D ( Tiano & Mauvais-Jarvis 2012 ). Beyond this, males and females also show divergent responses in terms of diabetes complications, efficacy
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Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA
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Department of Cell and Microbiology, Weill Cornell Medical College, New York, New York, USA
Department of Genetics, The University of Texas Anderson Cancer Center, Houston, Texas, USA
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Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas, USA
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Department of Cell and Microbiology, Weill Cornell Medical College, New York, New York, USA
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effects ranging from β-cell proliferation and changes in islet and β-cell area and mass ( Ackermann & Gannon 2007 ), insulin and glucose deviations ( Surwit et al. 1988 ), and whole body metabolite alterations including pancreas, liver, fat, and bone
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Department of Physiology and Biophysics, The Centre for Clinical and Experimental Transplantation (CCET), Australian Islet Transplant Consortium, School of Medicine, Cooperative Research Centre for Cell Therapy Manufacturing (CRC-CTM), Mawson Institute, Gene Therapy and Autoimmunity Group, Centre for Stem Cell Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
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Introduction Islet transplantation is an emerging therapy for highly selected patients with type 1 diabetes mellitus (T1D) and is now a funded treatment in the United Kingdom, France, Switzerland and recently in Australia ( McCall & Shapiro 2012
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identify candidate genes and relevant metabolic and signaling pathways regulated by FFA in human pancreatic islets. This is primarily due to the scarcity of human tissue for research purposes ( Haber et al . 2003 , 2006 , Newsholme et al . 2007 b
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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Department of Biomedical Sciences, Department of Molecular Biosciences, Department of Nutrition, Department of Internal Medicine, College of Veterinary Medicine, Cornell University, T7 022A Veterinary Research Tower (Box 17), Ithaca, New York 14850, USA
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, were two- to threefold higher in WAT in animals treated with pioglitazone compared with controls ( P <0.05; Fig. 5 E). Alogliptin did not significantly affect Akt or ERK1/2 phosphorylation. Pioglitazone and alogliptin treatment preserve islet
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA
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Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA
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most researchers studying glucose metabolism in mice. First, in vitro insulin secretion was compared in islets isolated from the six substrains. Then, in vivo assessments of insulin release in response to intravenous glucose were performed following
Department of Physiology & Pharmacology, Western University, London, Ontario, Canada
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Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada
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Department of Physiology & Pharmacology, Western University, London, Ontario, Canada
Department of Medicine, Western University, London, Ontario, Canada
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. 2008 ). There is evidence for rare pancreatic progenitor cells in human and mouse islets capable of multi-lineage differentiation and which express insulin ( Smukler et al. 2011 ). Importantly, these cells demonstrate low/absent glucose-transporter 2
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Department of Surgery and Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Pacific Northwest Research Institute, Seattle, Washington, USA
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Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Department of Surgery and Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle, Washington, USA
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Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Department of Surgery and Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle, Washington, USA
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Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Department of Surgery and Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle, Washington, USA
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Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
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Introduction Islet transplantation can result in insulin independence in patients diagnosed with type 1 diabetes ( Shapiro et al. 2003 ). To achieve a successful islet transplant, islets are first isolated from an organ donor