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E Y Faraoni Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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A I Abeledo Machado Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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P A Pérez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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C A Marcial López Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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M A Camilletti Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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M Peña-Zanoni Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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S B Rulli Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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S Gutiérrez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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G Díaz-Torga Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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( Kovacs et al. 2001 , Farrell 2006 ). Prolactinomas, which derive from hypertrophy and hyperplasia of lactotroph cells, are the pituitary tumours with the highest incidence in the clinic ( Ciccarelli et al. 2005 ). Sexual differences in the clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0326
Volume/Issue:
Volume 244: Issue 2
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María Andrea Camilletti Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Alejandra Abeledo-Machado Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Jimena Ferraris Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina

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Pablo A Pérez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Erika Y Faraoni Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Daniel Pisera Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina

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Silvina Gutierrez Centro de Microscopia Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Medicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Graciela Díaz-Torga Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina

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Introduction The involvement of estrogens in the control of pituitary function has been extensively studied (reviewed in Seilicovich 2010 ). Initially, estradiol was described to induce lactotroph proliferation through ERα; however, apoptotic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0402
Volume/Issue:
Volume 240: Issue 2
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Alejandra Abeledo-Machado Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Pablo Anibal Pérez Centro de Microscopía Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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María Andrea Camilletti Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Erika Yanil Faraoni Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Florencia Picech Centro de Microscopía Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Juan Pablo Petiti Centro de Microscopía Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Silvina Gutiérrez Centro de Microscopía Electrónica, Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

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Graciela Diaz-Torga Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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). Nevertheless, other hypothalamic factors have been reported to contribute to prolactin inhibition such as gamma-aminobutyric acid (GABA), somatostatin, and opiates, among others ( Leong et al. 1983 , Grattan 2015 ). On the other hand, although lactotrophs

Article Type:
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DOI:
https://doi.org/10.1530/JOE-20-0041
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Volume 246: Issue 1
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Alejandra Abeledo-Machado Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Dana Bornancini Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Milagros Peña-Zanoni Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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María Andrea Camilletti Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Erika Yanil Faraoni Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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Graciela Díaz-Torga Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina

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involving prolactin-inhibiting and prolactin-releasing factors. These mechanisms impact on prolactin synthesis, storage and release during postnatal development ( Chen 1987 , Becú-Villalobos et al. 1992 ). As lactotrophs constitutively synthesize and

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https://doi.org/10.1530/JOE-23-0020
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Volume 258: Issue 3
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Xiaoqin Fu
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Shotaro Nishimura
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Tom E Porter
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-stimulating hormone, somatotrophs secrete growth hormone (GH) and lactotrophs secrete prolactin (PRL). Although morphological studies suggest that all of these cell types arise from a progenitor cell type in Rathke’s pouch ( Dasen & Rosenfeld 2001 ), differentiation

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05799
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Volume 183: Issue 2
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Emma Castrique Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Marta Fernandez-Fuente Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Paul Le Tissier Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Andy Herman Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Andy Levy Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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, Ahlbom et al . 1998 ), ‘massive degeneration’ ( Orgnero de Gaisan et al . 1993 ), autolytic changes ( Aoki et al . 1996 ), and bi-directional lactotroph to somatotroph transdifferentiation ( Porter et al . 1991 ) have been implicated to account for it

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DOI:
https://doi.org/10.1677/JOE-09-0414
Volume/Issue:
Volume 205: Issue 1
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Ana I Arroba Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain

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Alfonso M Lechuga-Sancho Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain

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Laura M Frago Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain

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Jesús Argente Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain

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Julie A Chowen Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain

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hypoglycemia ( Kinsley et al. 1996 ). We have previously demonstrated that there is a reduction in the number of lactotrophs in the rat pituitary after 8 weeks of poorly controlled diabetes ( Arroba et al. 2003 ), which could explain the decrease in

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06908
Volume/Issue:
Volume 191: Issue 1
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Zhenhua Wang Department of Physiology, Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan
Department of Physiology, Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan

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Tetsuo Mitsui Department of Physiology, Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan

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Maho Ishida Department of Physiology, Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan

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Jun Arita Department of Physiology, Department of Physiology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan

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vectors will aid with correctly interpreting experimental data. Therefore, in this study, we used the rat pituitary lactotroph in the primary culture as a model for studying how adenovirus vector infection modulates cell proliferation. We found that the

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Research Article
DOI:
https://doi.org/10.1677/JOE-08-0102
Volume/Issue:
Volume 198: Issue 1
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N Zlocowski Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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L d V Sosa Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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B De la Cruz-Thea Cellular and Molecular Neurobiology Department, CONICET - Universidad Nacional de Córdoba - Instituto de Investigación Médica Mercedes y Martín Ferreyra, Córdoba, Argentina

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C B Guido Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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M G Martín Cellular and Molecular Neurobiology Department, CONICET - Universidad Nacional de Córdoba - Instituto de Investigación Médica Mercedes y Martín Ferreyra, Córdoba, Argentina

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J H Mukdsi Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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A I Torres Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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J P Petiti Centro de Microscopía Electrónica, Facultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, ArgentinaFacultad de Ciencias Médicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Científicas Técnicas (INICSA-CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina

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participation of the EZH2/H3K27me3 axis in the proliferation of lactotroph tumor cells. Materials and methods Animal and murine experimental pituitary tumor model Three-month-old male Fisher rats were housed under controlled temperature (21 ± 3°C

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0195
Volume/Issue:
Volume 257: Issue 2
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A. I. Torres
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A. Aoki
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ABSTRACT

The intracellular localization of different molecular forms of prolactin was studied in various experimental models covering a wide range of secretory states.

By correlating electron microscopy, morphometry and quantification of monomeric (small) and polymeric (big) prolactin after differential extraction procedures, big prolactin was found stored in secretory granules while small prolactin was loosely associated with all organelles involved in hormone synthesis and processing. No correlation with levels of lactotrophic secretory activity was detected by either the number of secretory granules or prolactin content in lactotrophs.

J. Endocr. (1985) 105, 219–225

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.1050219
Volume/Issue:
Volume 105: Issue 2
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