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Affiong Ika Oqua
Affiong Ika Oqua
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Yusman Manchanda
Yusman Manchanda
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Emma Rose McGlone
Emma Rose McGlone
Department of Surgery and Cancer, Imperial College London, London, UK
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Ben Jones
Ben Jones
Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Sarah Rouse
Sarah Rouse
Department of Life Sciences, Imperial College, London, UK
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Alejandra Tomas
Alejandra Tomas
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
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Introduction Lipids are structurally diverse organic compounds crucial for the normal functioning of all cells, as they are key constituents of membranes essential for cellular structure that enable the compartmentalisation of tightly
M B Mazzucco
M B Mazzucco
Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina
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R Higa
R Higa
Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina
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E Capobianco
E Capobianco
Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina
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M Kurtz
M Kurtz
Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina
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A Jawerbaum
A Jawerbaum
Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina
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V White
V White
Laboratory of Reproduction and Metabolism, School of Medicine, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, University of Buenos Aires, Paraguay 2155 17th floor CABA 1121, Buenos Aires, Argentina
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, which leads to enhanced lipid transfer through the placenta to the developing fetus. The placenta acts like a supplier and an exchange organ of oxygen, nutrients, and water. It also provides hormones and growing factors that modulate fetal and placental
Aldo Grefhorst
Aldo Grefhorst
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Johanna C van den Beukel
Johanna C van den Beukel
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Wieneke Dijk
Wieneke Dijk
Division of Human Nutrition, Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands
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Jacobie Steenbergen
Jacobie Steenbergen
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Gardi J Voortman
Gardi J Voortman
Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Selmar Leeuwenburgh
Selmar Leeuwenburgh
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Theo J Visser
Theo J Visser
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Sander Kersten
Sander Kersten
Division of Human Nutrition, Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands
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Edith C H Friesema
Edith C H Friesema
Section of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Axel P N Themmen
Axel P N Themmen
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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Jenny A Visser
Jenny A Visser
Section of Endocrinology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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lipolysis ( Himms-Hagen 1972 ). Cold exposure in rodents has been shown to have profound effects on whole-body lipid metabolism. In particular, cold exposure lowers plasma triglyceride (TG) concentrations by enhancing lipolytic clearance of VLDL TG by BAT
Hyo Youl Moon
Hyo Youl Moon
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Parkyong Song
Parkyong Song
BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea
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Cheol Soo Choi
Cheol Soo Choi
BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea
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Sung Ho Ryu
Sung Ho Ryu
BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea
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Pann-Ghill Suh
Pann-Ghill Suh
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accumulation of neutral lipids, mainly triglycerides (TGs), without ethanol consumption, viral infection, or other etiologies. NAFLD ranged from simple steatosis to cirrhosis accompanied by oxidative stress and hepatic injury ( Angulo 2002 ). Although the
Mohamed Asrih
Mohamed Asrih
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Genève 14, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospital, Rue Gabrielle‐Perret‐Gentil 4, 1211 Genève 14, Switzerland
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cellular mechanisms involved in the development of insulin resistance associated with NAFLD, focusing on the role of ectopic lipid deposition in this process, i.e. deposition of lipids outside of the adipose tissue, such as in the liver or skeletal muscle
Qiong Lv
Qiong Lv
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Rufei Gao
Rufei Gao
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Laboratory of Lipids and Glucose Metabolism, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chuan Peng
Chuan Peng
School of Public Health and Management, Chongqing Medical University, Chongqing, China
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Juan Yi
Juan Yi
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Lulu Liu
Lulu Liu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shumin Yang
Shumin Yang
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Danting Li
Danting Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Jinbo Hu
Jinbo Hu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ting Luo
Ting Luo
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Mei Mei
Mei Mei
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Ying Song
Ying Song
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chaodong Wu
Chaodong Wu
Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA
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Xiaoqiu Xiao
Xiaoqiu Xiao
School of Public Health and Management, Chongqing Medical University, Chongqing, China
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Qifu Li
Qifu Li
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Introduction Excess hepatic deposition of lipids, especially triglyceride (TG), is one of the important features of nonalcoholic fatty liver disease (NAFLD). Over-nutrition, metabolic diseases and genetic factors were widely considered to
Nicole G Barra
Nicole G Barra
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Fernando F Anhê
Fernando F Anhê
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Joseph F Cavallari
Joseph F Cavallari
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Anita M Singh
Anita M Singh
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Darryl Y Chan
Darryl Y Chan
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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Jonathan D Schertzer
Jonathan D Schertzer
Department of Biochemistry and Biomedical Sciences, Department of Biochemistry and Biomedical Sciences, Farncombe Family Digestive Health Research Institute, Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada
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microbial composition, increased microbial metabolites such as short-chain fatty acid (SCFA) levels in the colon, increased adipose tissue mass, and changed hepatic gene expression related to carbohydrate and lipid metabolism ( Cho et al. 2012 ). Studies
Shannon M Bailey
Shannon M Bailey
Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology
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Uduak S Udoh
Uduak S Udoh
Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology
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Martin E Young
Martin E Young
Division of Molecular and Cellular Pathology, Division of Cardiovascular Diseases, Department of Pathology
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control of carbohydrate, lipid, protein, and NAD + metabolism. Clock control of carbohydrate metabolism Dramatic time-of-day-dependent oscillations in glucose metabolism are observed in both humans and rodent models, at both the whole body level and the
Michael E Symonds
Michael E Symonds
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
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Nottingham Digestive Disease Centre and Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK
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Mark Pope
Mark Pope
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
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Ian Bloor
Ian Bloor
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
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James Law
James Law
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
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Reham Alagal
Reham Alagal
Department of Physical Sport Science, Princess Nourah Bint AbdulRahman University, Riyadh, Saudi Arabia
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Helen Budge
Helen Budge
Early Life Research Unit, Division of Child Health, Obstetrics & Gynaecology, University of Nottingham, Nottingham, UK
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. 2020 ). In one study, daily administration of 100 mg of mirabegron to healthy adult females ( n = 14) for 4 weeks stimulated brown fat activity, in conjunction with an improved circulating lipid profile and insulin sensitivity ( O’Mara et al. 2020
Karsten Suhre
Karsten Suhre
Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar
Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar
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Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar
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’ metabolites have not yet been detected in a biological sample. These ‘expected’ metabolites comprise, in particular, lipid species that are made up of several fatty acid side chains with different chain lengths and degrees of desaturation that may occur in a
