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Martina Bugáňová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Helena Pelantová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martina Holubová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Šedivá Faculty of Applied Sciences, University of West Bohemia, Plzeň, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Železná Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Petr Kačer Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Marek Kuzma Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martin Haluzík Centre for Experimental Medicine and Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

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along with improved blood pressure and circulating lipid levels ( Davidson 2011 ). They can be used in a wide range of patients with T2DM including those on insulin therapy. Furthermore, the most widely used representative of this class liraglutide has

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0478
Volume/Issue:
Volume 233: Issue 1
Free access
Jordan S F Chan Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Amanda A Greenwell Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Christina T Saed Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Magnus J Stenlund Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Indiresh A Mangra-Bala Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Seyed Amirhossein Tabatabaei Dakhili Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Kunyan Yang Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Sally R Ferrari Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Farah Eaton Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Keshav Gopal Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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John R Ussher Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, Canada

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Events with a Weekly Incretin in Diabetes), liraglutide (LEADER; Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results), and semaglutide (SUSTAIN 6; Trial to Evaluate Cardiovascular and Other Long-term Outcomes with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0032
Volume/Issue:
Volume 262: Issue 2
Restricted access
Paul Millar SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Nupur Pathak SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Vadivel Parthsarathy SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Anthony J Bjourson Northern Ireland Centre for Stratified Medicine, University of Ulster, C-TRIC Building, Altnagelvin Hospital, Northern Ireland, UK

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Maurice O’Kane Northern Ireland Centre for Stratified Medicine, University of Ulster, C-TRIC Building, Altnagelvin Hospital, Northern Ireland, UK
Clinical Chemistry Laboratory, Western Health and Social Care Trust, Altnagelvin Hospital, Northern Ireland, UK

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Varun Pathak SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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R Charlotte Moffett SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Peter R Flatt SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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Victor A Gault SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Northern Ireland, UK

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actions in animal models of diabetes-obesity, Alzheimer’s disease (AD) and Parkinson’s disease (PD) ( Ashraghi et al . 2016 , Tramutola et al . 2017 ). Liraglutide (Victoza) is a highly effective long-acting GLP-1 agonist that shares 97% sequence

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0263
Volume/Issue:
Volume 234: Issue 3
Free access
Natassia Rodrigo Renal Research Laboratory, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia
North Precinct, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, St Leonards, New South Wales, Australia
Department of Diabetes and Endocrinology, Nepean Hospital, Sydney, New South Wales, Australia

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Hui Chen School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia

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Carol A Pollock Renal Research Laboratory, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia
North Precinct, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia

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Sarah J Glastras Renal Research Laboratory, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia
North Precinct, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
Department of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, St Leonards, New South Wales, Australia

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T2D, affecting a range of tissues to optimise metabolic function, including adipose tissue and the pancreas ( Mancini & de Melo 2017 , Drucker 2018 ). Thus, we hypothesised that obese females treated with diet modification or liraglutide in the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0399
Volume/Issue:
Volume 253: Issue 1
Restricted access
Li Zhao Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Chunfang Zhu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Meng Lu Research Center for Clinical Medicine, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Chi Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Xiaomin Nie Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Buatikamu Abudukerimu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Kun Zhang Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Zhiyuan Ning Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Yi Chen Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Jing Cheng Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Fangzhen Xia Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Ningjian Wang Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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Michael D Jensen Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA

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Yingli Lu Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China

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-IV inhibitors and GLP-1 receptor agonists (GLP-1RAs) are introduced. Liraglutide is a GLP-1RA that shares 97% homology to native GLP-1 and extends the circulating half-life of GLP-1 from 1 to 2 min to 13 h. A series of Liraglutide Effect and Action in Diabetes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0374
Volume/Issue:
Volume 240: Issue 2
Free access
Neil Tanday SAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Peter R Flatt SAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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Nigel Irwin SAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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R Charlotte Moffett SAAD Centre for Pharmacy and Diabetes, Ulster University, Coleraine, Northern Ireland, UK

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incretin receptor signalling pathways in each rodent model, through sub-chronic administration of the clinically approved GLP-1 receptor agonist, liraglutide, or the didpeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin. Together these studies

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0451
Volume/Issue:
Volume 245: Issue 1
Restricted access
Katherine N Balantekin Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA
Center for Ingestive Behavior Research, University at Buffalo, Buffalo, New York, USA

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Martin J Kretz Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA

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Elizabeth G Mietlicki-Baase Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York, USA
Center for Ingestive Behavior Research, University at Buffalo, Buffalo, New York, USA

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weight loss as part of obesity care ( Rubino et al. 2021 ). In terms of the investigation of how long-acting GLP-1R agonists impact binge eating, liraglutide has been the most well-researched, though there has only been one blinded randomized controlled

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0405
Volume/Issue:
Volume 262: Issue 1
Restricted access
Hongbin Liu Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia

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Anthony E Dear Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia

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Lotte B Knudsen Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia

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Richard W Simpson Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia
Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Novo Nordisk A/S, Department of Diabetes and Endocrinology, Monash University, 6th Floor Burnett Tower, 89 Commercial Road, Prahran 3181, Melbourne, Victoria, Australia

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protected from the development of biochemical abnormalities associated with endothelial cell dysfunction and development of atherosclerosis ( Eitzman et al . 2000 , Mao et al . 2004 ). Liraglutide, an acylated glucagon-like peptide-1 (GLP-1) analogue, has

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0468
Volume/Issue:
Volume 201: Issue 1
Free access
Jennifer S ten Kulve Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Dick J Veltman Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands

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Liselotte van Bloemendaal Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Paul F C Groot Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands

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Henricus G Ruhé Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands

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Frederik Barkhof Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Michaela Diamant Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Richard G Ijzerman Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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CNS activation, measured with fMRI, in response to palatable food. We also investigated the effects of treatment with the GLP1RA liraglutide in T2DM patients on CNS activation to palatable food. Materials and methods Subjects This study

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0461
Volume/Issue:
Volume 229: Issue 1
Free access
Andreas Nygaard Madsen
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Gitte Hansen
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Sarah Juel Paulsen
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Kirsten Lykkegaard
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Mads Tang-Christensen
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Harald S Hansen Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark

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Barry E Levin Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark
Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark

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Philip Just Larsen
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Lotte Bjerre Knudsen Rheoscience A/S, Faculty of Pharmaceutical Sciences, Neurology Service, Department of Neurology and Neurosciencies, NovoNordisk A/S, Rødovre 2610, Copenhagen, Denmark

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Keld Fosgerau
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Niels Vrang
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the novel human GLP-1 analog liraglutide for 28 days. Materials and Methods Animals All experiments were conducted in accordance with internationally accepted principles for the care and use of laboratory animals, and were approved by the Danish

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0004
Volume/Issue:
Volume 206: Issue 3
Free access