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Aldo Grefhorst, Johanna C van den Beukel, Wieneke Dijk, Jacobie Steenbergen, Gardi J Voortman, Selmar Leeuwenburgh, Theo J Visser, Sander Kersten, Edith C H Friesema, Axel P N Themmen and Jenny A Visser

increasing the conversion of cholesterol to bile acids (BAs) ( Worthmann et al. 2017 ). Of interest, the liver is the main metabolic organ that controls whole-body TG, cholesterol and BA metabolism. With respect to TG homeostasis, the liver is able to

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Prabhakara R Nagareddy, Sunil K Noothi, Michelle C Flynn and Andrew J Murphy

emphasis on reticulated platelets and the role of the liver in regulating megakaryopoiesis and thrombopoiesis. Cardiovascular risk factor contribution to myelopoiesis As stated earlier, monocyte levels are associated with CAD. However, different

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E M de Vries, H C van Beeren, M T Ackermans, A Kalsbeek, E Fliers and A Boelen

, the peripheral handling of THs is also markedly altered during fasting ( Vagenakis et al . 1977 , Harris et al . 1978 ). In the liver, an important site for TH metabolism, type 1 deiodinase (D1) and type 3 deiodinase (D3) are expressed. Type 1

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Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu and Pann-Ghill Suh

2008 ). Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic component of metabolic syndrome, which is highly associated with obesity and insulin resistance ( Postic & Girard 2008 ). A representative phenomenon of NAFLD is hepatic

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Peixin Li, Zhijian Rao, Brenton Thomas Laing, Wyatt Bunner, Taylor Landry, Amber Prete, Yuan Yuan, Zhong-Tao Zhang and Hu Huang

considered to be primarily from limited energy intake. Benefits include enhanced insulin action in skeletal muscle ( Friedman et al. 1992 ), decreased fat content in adipose tissue ( Dadson et al. 2016 ) and suppressed fat accumulation in the liver

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Mohamed Asrih and François R Jornayvaz

Introduction Nonalcoholic fatty liver disease (NAFLD) is a major health problem considered to be the most common chronic liver disorder in the Western countries. NAFLD is estimated to affect at least 30% of the general population ( Ratziu et al

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Nikolaos Nikolaou, Anastasia Arvaniti, Nathan Appanna, Anna Sharp, Beverly A Hughes, Dena Digweed, Martin J Whitaker, Richard Ross, Wiebke Arlt, Trevor M Penning, Karen Morris, Sherly George, Brian G Keevil, Leanne Hodson, Laura L Gathercole and Jeremy W Tomlinson

Introduction Glucocorticoids (GCs) are steroid hormones that are released in response to stress and play a crucial role in inflammation and in carbohydrate, lipid and protein metabolism. Within key metabolic target tissues, notably the liver

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Hiroto Kobayashi, Saori Yoshida, Ying-Jie Sun, Nobuyuki Shirasawa and Akira Naito

& Armstrong 1995 ). Among liver disease, cirrhosis, pylemphraxis, and biliary atresia, there is an increase in the serum estrogen levels in males; however, the origin of serum estrogens is unknown. In recent years, Ueyama et al . (2002 , 2004 ) reported the

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Ling He, Shumei Meng, Emily L Germain-Lee, Sally Radovick and Fredric E Wondisford

diabetic patients treated with metformin exhibit a reduction in cancer incidence ( Evans et al . 2005 , Libby et al . 2009 , Landman et al . 2010 ). The main effect of metformin is to suppress glucose production in the liver ( Hundal et al . 2002

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María E Díaz, Johanna G Miquet, Soledad P Rossi, Pablo E Irene, Ana I Sotelo, Mónica B Frungieri, Daniel Turyn and Lorena González

indicates that GH concentration patterns regulate epidermal growth factor receptor (EGFR) expression in rodent liver. The EGFR, also known as ERBB1, is a plasma membrane glycoprotein which belongs to the ERBB family of receptor tyrosine kinases ( Burgess