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Nele Friedrich Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Ferdinand-Sauerbruch-Strasse, D-17475 Greifswald, Germany

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Endocrinologists 2007 ), which highlights the need for early screening markers to monitor the development of T2DM. During the last decade, the rapidly growing research field of metabolomics has introduced new insights into the pathology of diabetes as well as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0120
Volume/Issue:
Volume 215: Issue 1
Free access
Robin Haring Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Strasse, D-17475 Greifswald, Germany

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-onset hypogonadism, remains a controversial concept with several outstanding questions ( Box 1 ). Metabolomics for the improved diagnosis, therapy and monitoring of ADS The principle techniques of metabolomics Against the background of the various uncertainties

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0119
Volume/Issue:
Volume 215: Issue 1
Free access
Maik Pietzner Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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Tim Kacprowski Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan Technical University of Munich, Freising-Weihenstephan, Germany

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Nele Friedrich Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

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. Metabolomics THs affect diverse aspects of human metabolism and metabolomics techniques are ideally suited to map and connect these effects in a hypothesis-free manner. Figure 2 provides a sketch summarizing important findings from metabolomics studies with

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0117
Volume/Issue:
Volume 238: Issue 1
Free access
Michael Merkhassine Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
VCA Colonial Animal Hospital, Ithaca, New York, USA

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Reilly W Coch Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
Weill Cornell College of Medicine, New York, New York, USA

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Carol E Frederick Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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Lucinda L Bennett Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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Seth A Peng Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA
Fate Therapeutics, San Diego, California, USA

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Benjamin Morse Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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Bethany P Cummings Center for Alimentary and Metabolic Science, Department of Surgery, School of Medicine, University of California, Davis, Sacramento, California, USA
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA

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John P Loftus Loftus Laboratory, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine, Ithaca, New York, USA

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hyperglucagonemia on glucose and AA metabolism is lacking. We aimed to address two critical gaps in glucagon biology with broad applications for canine health and foundations for translational research. First was the lack of metabolomic data in dogs as a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0051
Volume/Issue:
Volume 262: Issue 2
Open access
Lucy M Hinder
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Anuradha Vivekanandan-Giri Department of Neurology, Department of Internal Medicine, University of Michigan, AATBSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, USA

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Lisa L McLean
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Subramaniam Pennathur Department of Neurology, Department of Internal Medicine, University of Michigan, AATBSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, USA

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Eva L Feldman
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et al . 2007 ), retina ( Ola et al . 2006 ), and lens ( Obrosova & Stevens 1999 ). Recent metabolomic studies in models of type 1 diabetes reported downregulation of key TCA cycle and mitochondrial proteins ( Akude et al . 2011 ) and enzyme

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0356
Volume/Issue:
Volume 216: Issue 1
Free access
Neele S Dellschaft Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Marie-Cecile Alexandre-Gouabau Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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David S Gardner Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Jean-Philippe Antignac Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Duane H Keisler Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Helen Budge Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Michael E Symonds Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Sylvain P Sebert Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
Early Life Research Unit, INRA and University of Nantes, School of Veterinary Medicine and Science, Institute of Health Sciences, Oniris, Department of Animal Science, Academic Division of Child Health, Obstetrics and Gynaecology, School of Medicine, Queen's Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK

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Washington, NY, USA) to remove high-molecular-weight species, proteins in particular (over 10 kDa). Metabolomic LC–HRMS profiles were acquired from 15 μl of each filtered serum sample using an Agilent 1200 HPLC system equipped with a 150×2.1 mm Uptisphere HDO

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0600
Volume/Issue:
Volume 224: Issue 2
Free access
Heleen I Jansen Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands

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Eveline Bruinstroop Department of Endocrinology & Metabolism, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Annemieke C Heijboer Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands

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Anita Boelen Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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using omics are used to examine not only one marker but determine multiple markers in order to unravel a panel of markers representing (tissue) TH status. Metabolomic profiling is a powerful tool for measuring the activity of metabolic tissues ( Newgard

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0364
Volume/Issue:
Volume 253: Issue 2
Free access
Henri Wallaschofski Institute of Clinical Chemistry and Laboratory Medicine, Metabolic Center, University Medicine Greifswald, Ernst‐Moritz‐Arndt University, Ferdinand‐Sauerbruch‐Strasse, D-17475 Greifswald, Germany

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be achieved by the approach of metabolomics. Metabolomics is a technique that provides a comprehensive assessment of small molecular mass organic compounds that are substrates or products of metabolic pathways as an individual fingerprint of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0270
Volume/Issue:
Volume 215: Issue 1
Free access
Georg Homuth
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Alexander Teumer
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Uwe Völker
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Matthias Nauck Department of Functional Genomics, Institute for Clinical Chemistry and Laboratory Medicine, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Straße 15A, D-17487 Greifswald, Germany

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Toward a combination of genomics and metabolomics: a chronology Technological prerequisites and general significance Key prerequisites for the feasibility of genome-wide association studies (GWAS) were the availability of a first human genome

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0144
Volume/Issue:
Volume 215: Issue 1
Free access
Martina Bugáňová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Helena Pelantová Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martina Holubová Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Šedivá Faculty of Applied Sciences, University of West Bohemia, Plzeň, Czech Republic

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Lenka Maletínská Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Blanka Železná Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Jaroslav Kuneš Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Petr Kačer Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Faculty of Chemical Technology, University of Chemistry and Technology Prague, Prague, Czech Republic

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Marek Kuzma Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Martin Haluzík Centre for Experimental Medicine and Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

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therapies. NMR-based metabolomics in biofluids (e.g. urine or blood plasma) has become a strong tool for monitoring of different physiological and pathological processes as well as the response to the various therapeutic interventions ( Nicholson et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0478
Volume/Issue:
Volume 233: Issue 1
Free access