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Introduction Metformin, the most widely used antidiabetic drug, is considered as the cornerstone of type 2 diabetes treatments. Surprisingly, a few years ago, it has been reported that serum TSH level in hypothyroid patients decreased in
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). Metformin, a biguanide that was introduced as an anti-diabetic agent, acts through inhibition of hepatic gluconeogenesis and stimulation of glucose uptake into peripheral tissues ( Sarabia et al . 1992 , Radziuk et al . 1997 ). Recently, metformin has
Department of Integrated Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China
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Department of Integrated Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China
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Introduction Metformin is the first-line antihyperglycemia agent for T2DM patients. The mechanisms by which metformin improves glycemic control is mainly by reducing hepatic glucose production, and to a lesser extent, via enhancing peripheral
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in subcutaneous and omental adipose tissue(s) of women with PCOS. Furthermore, we studied the effects of glucose and metformin on adipolin protein production in human subcutaneous adipose tissue explants. Subjects and methods Subjects All women with
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China
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Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
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Department of Integrative Medicine and Neurobiology, State Key Lab of Medical Neurobiology, Shanghai Medical College and Institute of Acupuncture Research (WHO Collaborating Center for Traditional Medicine), Institute of Brain Science, Fudan University, Shanghai, China
Institute of Integrative Medicine of Fudan University, Shanghai, China
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Department of Gynecology Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, China
Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China
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et al. 2013 , Tapia-Pizarro et al. 2017 ), it remains to be determined whether suppression of MAPK/ERK signaling occurs in the endometrium and whether such dysregulation can negatively impact uterine function under PCOS conditions. Metformin is
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School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
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School of Medicine, University of Tasmania, Hobart, Tasmania, Australia
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Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia
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Introduction Metformin is the most common first-line oral glucose-lowering pharmacological therapy for people with type 2 diabetes ( Bailey & Turner 1996 , Gunton & Twigg 2003 , Inzucchi et al. 2015 a , b ). It is primarily known for
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. Administration of metformin (a biguanide used to treat insulin resistance and diabetes mellitus 2) to obese pregnant rats reportedly reduces fetal liver inflammation ( Harris et al. 2016 ), preventing liver alterations developing in offspring growing in an
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
Centre for Addiction and Mental Health, Institute of Medical Science, Department of Psychiatry, Department of Physiology, 250 College Street, Toronto, Ontario, Canada M5T 1R8
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remains as to whether anti-diabetic drugs are efficacious in reversing these direct molecular effects. Metformin (Met), a first-line treatment in the general population for pre-diabetes and DM2 ( Canadian Diabetes Association Clinical Practice Guidelines
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Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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the inactive state (GPb). The activation of GS and the depletion of GPa finally result in the stimulation of glycogen synthesis ( Agius 2015 ). Metformin, a potent biguanide hypoglycemic agent, has been clinically used for over five decades and is
Department of Physiology, Medical University of Bialystok, Bialystok, Poland
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Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland
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Department of Perinatology, Medical University of Bialystok, Bialystok, Poland
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Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland
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of associated enzymes and correlate lipid variables with skeletal muscle IR in HFD-fed rats. We used the well-defined experimental model of HFD-induced skeletal muscle IR in rat and employed commonly prescribed insulin sensitizer, metformin, to