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Niels L Mulder, Rick Havinga, Joost Kluiver, Albert K Groen and Janine K Kruit

et al. 2014 , Belgardt et al. 2015 ). Obesity, a major risk factor for type 2 diabetes mellitus, is known to change miRNA expression in islets ( Zhao et al. 2009 , Nesca et al. 2013 ). One of these miRNAs, miR-132, is of particular interest

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F X Donadeu, S N Schauer and S D Sontakke

Increase during follicular atresia Pig ( Lin et al . 2012 ) miR-132/miR-212 Granulosa ND Ctbp1 Increase during hCG-induced ovulation Mouse ( Fiedler et al . 2008 ) miR-21 Granulosa Anti-apoptotic (shown in vivo ) ND Increase during hCG

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Juliano C da Silveira, Ana Clara F C M de Ávila, Hannah L Garrett, Jason E Bruemmer, Quinton A Winger and Gerrit J Bouma

), respectively, genes known to be involved in oocyte maturation and cumulus expansion ( Assou et al. 2006 , McBride et al. 2012 ). Similarly, miR-21, miR-132 and miR-212 are examples of microRNAs regulated by hCG/LH in periovulatory mouse granulosa cells and

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Omkaram Gangisetty, Shaima Jabbar, Olivia Wynne and Dipak K Sarkar

identified changes in various miRs during pituitary tumorigenesis. It has been reported that miR-15a, miR-16 and miR-132 are downregulated ( Bottoni et al. 2007 , Renjie & Haiqian 2015 ) while miR-200C is upregulated in pituitary adenoma ( Mao et al

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Haiyong Chen, Hui-Yao Lan, Dimitrios H Roukos and William C Cho

serum miRNAs (miR-132, miR-29a, and miR-222) can predict gestational DM with 66.7% sensitivity and 63.3% specificity (area under the curve=0.642). So far no commercial products are available for diabetes diagnosis. The potential clinical use of miRNAs as

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Yuxun Zhou, Li Tong, Maochun Wang, Xueying Chang, Sijia Wang, Kai Li and Junhua Xiao

miR-200b and miR-429 could induce reduced fertility in female mice ( Hasuwa et al. 2013 ). Zhu et al. showed that the variation in the Lin28/let7 pathway changed the body size and puberty timing in mice ( Zhu et al. 2010 ). Furthermore, miR-132

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Kimberley C W Wang, Kimberley J Botting, Song Zhang, I Caroline McMillen, Doug A Brooks and Janna L Morrison

, Gao et al . 2014 , Wang et al . 2014 ). In vitro cardiac fibroblast studies have also shown that AT 1 R can regulate various miRs ( Jeppesen et al . 2011 ) and also appear to be a target of the miR-132/212 family ( Eskildsen et al . 2015