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Maria Konstandi, Christina E Andriopoulou, Jie Cheng, and Frank J Gonzalez

role of female sex hormones in hepatic CYP2D regulation using ovariectomized WT and CYP2D6-humanised (hcyp2D6) mice, supplemented with 17β-estradiol and/or progesterone. In order to further elucidate the role of estrogens in CYP2D regulation, tamoxifen

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K Eerola, S Virtanen, L Vähätalo, L Ailanen, M Cai, V Hruby, M Savontaus, and E Savontaus

effects of MSH peptides in the CNS. Mc4r- knockout (KO) mice are severely obese, and SNPs in the MC4R gene are associated with higher BW in humans and MC4R agonists have potent anti-obesity effects ( Huszar et al. 1997 , Vaisse et al. 1998 , Marsh

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Naomi Fleury, Martin Feelisch, Prue H Hart, Richard B Weller, Jordan Smoothy, Vance B Matthews, and Shelley Gorman

57Bl/6 mice fed a high-fat diet ( Geldenhuys et al . 2014 ). UV-irradiated mice had reduced weight gain and diminished metabolic dysfunction including decreased fasting glucose and insulin levels, improved glucose tolerance, reduced insulin

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Shabana Anjum, Amitabh Krishna, and Kazuyoshi Tsutsui

testis. We therefore sought to comprehensively examine the functional role of RFRP3 in the regulation of testicular activities with particular reference to spermatogenesis and steroidogenesis in mice. To study the in vivo effect of RFRP3 on

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Changjie Han, Yan Jiao, Qingguo Zhao, and Baisong Lu

that MEX3C has multiple functions, most likely through regulation of different mRNA targets in different cell types. Mouse Mex3c is highly similar to its human homolog. We generated Mex3c gene trap mice on a C57BL/6 background; homozygous mutant

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Abdoulaye Diané, Nikolina Nikolic, Alexander P Rudecki, Shannon M King, Drew J Bowie, and Sarah L Gray

) with a concurrent increase in BAT UCP1 expression ( Resch et al . 2013 ). In parallel, mice lacking PACAP showed decreased BAT thermogenic capacity and reduced sympathetic outflow to this organ ( Gray et al . 2001 , 2002 ). These studies are

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Louis Potier, Ludovic Waeckel, Fréderic Fumeron, Sophie Bodin, Marinos Fysekidis, Catherine Chollet, Naima Bellili, Fabrice Bonnet, Gaëlle Gusto, Gilberto Velho, Michel Marre, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby, and the DESIR study group

-of-function polymorphism of the Klk1 gene resulting in an inactivating mutation of the enzyme (R53H) has been described ( Slim et al . 2002 , Azizi et al . 2005 ). We evaluated the consequences for insulin sensitivity and glucose metabolism of lack of TK in mice with

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Jaroslav Kuneš, Veronika Pražienková, Andrea Popelová, Barbora Mikulášková, Jana Zemenová, and Lenka Maletínská

et al . 2002 ). Moreover, the anorexigenic peptide cholecystokinin (CCK) was shown to have no effect on food intake in PrRP-receptor-knockout mice. This finding suggested that PrRP acting through its receptor may be a key mediator in the central

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David E Maridas, Victoria E DeMambro, Phuong T Le, Kenichi Nagano, Roland Baron, Subburaman Mohan, and Clifford J Rosen

in both mice and humans. IGFBP-4 can bind IGF-1 and IGF-2 with higher affinity than the IGF receptor but when cleaved by PAPPA, it can no longer sequester IGF ( Mohan et al . 1995 , Zhou et al . 2003 , Mazerbourg et al . 2004 ). IGFBP-4 has

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Tristan S Allemann, Gursimran K Dhamrait, Naomi J Fleury, Tamara N Abel, Prue H Hart, Robyn M Lucas, Vance B Matthews, and Shelley Gorman

exposure to low doses (non-burning) of UVR suppressed weight gain and metabolic dysfunction in mice fed with a high-fat diet ( Geldenhuys et al . 2014 , Fleury et al . 2017 , Teng et al . 2019 ). These findings were independent of circulating 25