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Maria-Christina Zennaro INSERM, Paris Cardiovascular Research Center, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, Paris, France

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Fabio Fernandes-Rosa INSERM, Paris Cardiovascular Research Center, Paris, France
Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Génétique, Paris, France

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Introduction Aldosterone and the mineralocorticoid receptor (MR) play a key role in the regulation of electrolyte balance and blood pressure. Abnormalities in aldosterone and MR function lead to salt-losing disorders or hypertension

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0089
Volume/Issue:
Volume 234: Issue 1
Free access
Jun Yang Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia
Department of Medicine, Monash University, Clayton, Victoria, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Discovery & Preclinical Domain, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

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Timothy J Cole Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

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Peter J Fuller Centre of Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia

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effectively treated with mineralocorticoid receptor (MR) antagonists (MRAs). Targeted treatment of PA offers benefits above and beyond blood pressure control by mitigating the systemic effects of aldosterone-mediated MR activation ( Fig. 1 ). In this review

Article Type:
Review Article
Collections:
Endocrine Society of Australia special collection
DOI:
https://doi.org/10.1530/JOE-22-0249
Volume/Issue:
Volume 259: Issue 1
Free access
Peter J Fuller Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and the Monash University Department of Molecular Translational Science, Clayton, Victoria, Australia

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Jun Yang Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and the Monash University Department of Molecular Translational Science, Clayton, Victoria, Australia

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Morag J Young Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research and the Monash University Department of Molecular Translational Science, Clayton, Victoria, Australia

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Introduction The cloning of the mineralocorticoid receptor (MR) by Jeff Arriza working in the laboratory of Ron Evans ( Arriza et al . 1987 ) marked a critical inflexion point for research on aldosterone action. It followed the cloning of the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0060
Volume/Issue:
Volume 234: Issue 1
Free access
Katarzyna Czarzasta Department of Experimental and Clinical Physiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, Warszawa, Poland

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Luminita H Pojoga Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, Massachusetts, USA

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Mineralocorticoid receptor signaling and cardiovascular disease While classically described as regulators of sodium and volume homeostasis in the kidney, aldosterone, and its receptor – the mineralocorticoid receptor (MR) – are increasingly

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0341
Volume/Issue:
Volume 262: Issue 3
Restricted access
Nikshay Karthigan Cardiovascular Endocrinology Laboratory, Baker Heart and Diabetes Institute, Prahran, Australia
Endocrine Hypertension Group, Hudson Institute of Medical Research, Clayton, Australia

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Siobhan Lockwood Monash Cardiovascular Research Centre, Monash Health, Clayton, Australia
Department of Medicine, Monash University, Clayton, Australia

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Anthony White Monash Cardiovascular Research Centre, Monash Health, Clayton, Australia
Department of Medicine, Monash University, Clayton, Australia

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Jun Yang Endocrine Hypertension Group, Hudson Institute of Medical Research, Clayton, Australia
Department of Medicine, Monash University, Clayton, Australia

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Morag J Young Cardiovascular Endocrinology Laboratory, Baker Heart and Diabetes Institute, Prahran, Australia

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Introduction The purpose of this review is to explore whether the use of existing and novel biomarkers may have the potential to assist in the identification of patients with heart failure (HF) expected to respond to mineralocorticoid receptor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0323
Volume/Issue:
Volume 253: Issue 3
Free access
Alberto González-Mayoral INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France
Paris Brain Institue-Institut du Cerveau, CNRS UMR7225, INSERM U1127, Hôpital de la Pitié Salpêtrière, Paris, France

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Axel Eid INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France
INSERM UMR 1195 (DHNS), Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France

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Razmig Derounian INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Virginia Sofia Campanella INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Andreia da Silva Ramos INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Romy El Khoury INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Charbel Massaad INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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Damien Le Menuet INSERM UMRS 1124 (T3S), Faculty of Basic and Biomedical Sciences, Université Paris Cité, Paris, France

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-Böhm et al. 2018 ). GC actions are mediated by two highly homologous members of the nuclear receptor superfamily, the mineralocorticoid receptor MR, coded by the Nr3c2 gene also named Mr ( Viengchareun et al. 2007 ) and the GC receptor GR ( Oakley

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0334
Volume/Issue:
Volume 258: Issue 2
Restricted access
Clara Lefranc INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France

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Malou Friederich-Persson Medical Cell Biology, Uppsala University, Uppsala, Sweden

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Roberto Palacios-Ramirez INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France

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Aurelie Nguyen Dinh Cat INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France

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have reported the importance of aldosterone and the mineralocorticoid receptor (MR) in CMS ( Zennaro et al. 2009 , Whaley-Connell et al. 2010 , Ronconi et al. 2012 , Even et al. 2014 ). Increasing evidence shows a link between obesity

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0163
Volume/Issue:
Volume 238: Issue 3
Free access
Erin Faught Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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Mathilakath M Vijayan Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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skeletal muscle mass ( Facchinello et al. 2017 , Faught & Vijayan 2019 a ). In teleosts, cortisol is the primary GC and the mode of action involves the activation of either GR and/or mineralocorticoid receptor (MR). Both these receptors are ligand

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0358
Volume/Issue:
Volume 244: Issue 2
Restricted access
Achim Lother Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Lisa Deng Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Michael Huck Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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David Fürst Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Jessica Kowalski Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Jennifer S Esser Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Martin Moser Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Christoph Bode Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Lutz Hein Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

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Introduction Aldosterone mediates its effects via the mineralocorticoid receptor (MR), a ligand-activated transcription factor. Upon binding of aldosterone, MR interacts with a distinct DNA motif to regulate transcription of its target genes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0494
Volume/Issue:
Volume 240: Issue 1
Free access
Carolina Gaudenzi Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Karen R Mifsud Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Johannes M H M Reul Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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the mineralocorticoid receptor (MR) ( Reul & de Kloet 1985 , 1986 , Reul et al. 1987 ). Both MRs and GRs are highly expressed in the hippocampus, a key limbic area of the brain which is critically involved in regulating adaptive responses to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0293
Volume/Issue:
Volume 258: Issue 2
Open access