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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
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Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India
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.e. hypothyroidism, induces critical damage to the central nervous system (CNS), often resulting in irreversible deficits ( Bernal 2000 , Di Liegro 2008 ). The cerebellum is vital for motor functions, and hypothyroidism impairs motor activity, associated with
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Department of Biological and Environmental Sciences, Department of Human and Social Sciences, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C. Valeria, Gazzi, 98100 Messina, Italy
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between neurological deficits in the setting of TBI, we used the rotarod test, which is considered as the most sensitive vestibulomotor to assess motor function. At 24 h after TBI, mice were subjected to the EBST. CCI-injured mice displayed a range of
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, corneal reflex, pinna reflex, pain response, ipsilateral flexor reflex, limb tone, righting reflex, and hypothermia). Rotarod treadmill test On day 10, motor function was evaluated in a rotarod treadmill apparatus (MK-660D, Muromachi Kikai Co., Ltd, Tokyo
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Maternal thyroid status influences early brain development and, consequently, cognitive and motor function in humans and rats. The biochemical targets of maternal thyroid hormone (TH) action in fetal brain remain poorly defined. A partially thyroidectomized rat dam model was therefore used to investigate the influence of maternal hypothyroxinemia on the specific activities of cholinergic and monoaminergic neurotransmitter metabolic enzymes in the developing brain. Maternal hypothyroxinemia was associated with reduced monoamine oxidase (MAO) activity in fetal whole brain at 16 and 19 days gestation (dg). A similar trend was observed for choline acetyltransferase (ChAT) activity. In contrast, DOPA decarboxylase (DDC) activity was markedly elevated at 21 dg. Further study of these enzymes at 14 dg showed no differences between normal and experimental progeny - suggesting they become TH sensitive after this age. Tyrosine hydroxylase (TyrH) and acetylcholinesterase (AChE) activities were unaffected prenatally. During postnatal development, the activities of TyrH, MAO, DDC and, to a lesser extent, AChE were increased in a brain region- and age-specific manner in experimental progeny. The prenatal disturbances noted in this study may have wide-ranging consequences since they occur when neurotransmitters have putative neurotropic roles in brain development. Furthermore, the chronic disturbances in enzyme activity observed during postnatal life may affect neurotransmission, thereby contributing to the behavioural dysfunction seen in adult progeny of hypothyroxinemic dams.
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predicted, but that cognitive function as assessed by the Morris water maze test was significantly better in the GH-treated animals, suggesting that GH improved the acquisition of spatial memory. GH has also been shown to accelerate recovery of motor
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effects, GLP1 is able to affect the motor functions of the gastrointestinal tract in different species, including humans ( Marathe et al . 2011 ). In fact, it inhibits gastric emptying, relaxes the antral region of the stomach, and reduces the motility of
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.05. Discussion To the best of our knowledge, this manuscript provides the first demonstration of the adverse effects of pyrethroids on the secretory and motoric functions of the cervix. Few data describe the involvement of pyrethroids in disturbances of the
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
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with DMD ( Ricotti et al. 2013 ). Motor function remained unchanged in the recently published clinical study of IGF-1 and in previous studies of GH in boys with DMD ( Cittadini et al. 2003 , Rutter et al. 2012 , 2020 ). It is notable that the
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dopaminergic neurons and rescued motor function in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesion mouse model of PD ( Li et al . 2009 ). Patient data analyses also confirmed that a higher percentage of PD patients were diabetic or had elevated levels
Department of Experimental Medical Science, Lund University, Lund, Sweden
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Department of Experimental Medical Science, Lund University, Lund, Sweden
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Department of Experimental Medical Science, Lund University, Lund, Sweden
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Department of Experimental Medical Science, Lund University, Lund, Sweden
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2006 Obesity does not increase effects of synthetic ghrelin on human gastric motor functions. Gastroenterology 131 1431 –1439. Date Y , Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S
