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Takuro Okamura Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

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Yoshitaka Hashimoto Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

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Takafumi Osaka Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
Department of Diabetology, Ayabe City Hospital, Ayabe, Japan

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Takafumi Senmaru Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

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Takuya Fukuda Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

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Masahide Hamaguchi Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

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Michiaki Fukui Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan

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difficulties, falls, and effects daily life activities ( Goodpaster et al. 2006 , Delmonico et al. 2007 ). It has also been reported that muscle atrophy increases the risk of death ( Cruz-Jentoft et al. 2010 ). The pathogenesis of skeletal muscle atrophy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0425
Volume/Issue:
Volume 244: Issue 3
Restricted access
Young Hoon Son Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Seok-Jin Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Ki-Baek Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Jin-Haeng Lee Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Eui Man Jeong Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea
Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Sun Gun Chung Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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Sang-Chul Park Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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In-Gyu Kim Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea
Department of Biochemistry and Molecular Biology, Institute of Human–Environment Interface Biology, Department of Rehabilitation Medicine, Seoul National University College of Medicine, 103 Daehak‐ro, Jongno‐Gu, Seoul 110‐799, Korea

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development of muscle atrophy, in which a loss of muscle mass leads to muscle weakness. Thus, muscle atrophy is considered to be a prognostic factor for underlying diseases ( Schakman et al . 2013 ). Glucocorticoids cause muscle atrophy by upregulating the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0490
Volume/Issue:
Volume 225: Issue 1
Open access
M Granado Department of Physiology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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A I Martín Department of Physiology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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T Priego Department of Physiology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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A López-Calderón Department of Physiology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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M A Villanúa Department of Physiology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain

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that seem to be specifically involved in myofibrillar protein degradation, the mouse atrophy gene-1 (atrogin-1; Gomes et al. 2001 ), also described as the rat muscle atrophy F-box (MAFbx; Bodine et al. 2001 ), and the rat muscle RING finger-1

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06931
Volume/Issue:
Volume 191: Issue 1
Free access
Yuriko Kitajima Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Yusuke Ono Department of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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muscle mass ( McClung et al . 2006 , Sitnick et al . 2006 , Sugiura et al . 2006 , Pollanen et al . 2011 ). Ovariectomized (OVX) mice fail to fully recover muscle mass after hindlimb suspension-induced muscle atrophy followed by reloading ( McClung

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0476
Volume/Issue:
Volume 229: Issue 3
Free access
Nele Cielen Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Nele Heulens Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Karen Maes Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Geert Carmeliet Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Chantal Mathieu Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Wim Janssens Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Ghislaine Gayan-Ramirez Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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. 2014 ). Low serum levels of vitamin D are known to be associated with reduced muscle strength and performance, and lead to muscle atrophy, increased apoptosis, decreased protein synthesis, and perturbation in intracellular calcium homeostasis ( Ceglia

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0491
Volume/Issue:
Volume 229: Issue 2
Open access
O Schakman Unité de Diabétologie et Nutrition, Faculté de Médecine, Université Catholique de Louvain, 54 Avenue Hippocrate, B-1200 Brussels, Belgium

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H Gilson Unité de Diabétologie et Nutrition, Faculté de Médecine, Université Catholique de Louvain, 54 Avenue Hippocrate, B-1200 Brussels, Belgium

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J P Thissen Unité de Diabétologie et Nutrition, Faculté de Médecine, Université Catholique de Louvain, 54 Avenue Hippocrate, B-1200 Brussels, Belgium

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skeletal muscle atrophy. The resulting weakness of peripheral and respiratory muscles may have major clinical implications such as loss of quality of life, fatigue, impaired wound healing, compromised lung function, and poor immune response. The purpose of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0606
Volume/Issue:
Volume 197: Issue 1
Free access
A M Solomon Department of Endocrinology, Royal Free Hospital and Medical School, Pond Street, London NW3 2PF, UK

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P M G Bouloux Department of Endocrinology, Royal Free Hospital and Medical School, Pond Street, London NW3 2PF, UK

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available myonuclei via inflammatory or apoptotic-like mechanisms represent alternative explanations for sarcopenia ( Leeuwenburgh 2003 ). Muscle atrophy in disuse, denervation and medical disorders Muscle atrophies with disuse, ageing

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06837
Volume/Issue:
Volume 191: Issue 2
Free access
Masahiro Ogawa Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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Tomoya Kitakaze Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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Naoki Harada Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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Ryoichi Yamaji Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka 5998531, Japan

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inhibits dexamethasone-induced muscle atrophy in L6 cells ( Sundaram et al . 2009 ). The biological functions of E 2 are exerted through its binding to two estrogen receptors (ERs), ERα and ERβ ( Heldring et al . 2007 ). The ERs bind to estrogen response

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0128
Volume/Issue:
Volume 225: Issue 3
Free access
Stuart A Morgan Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Zaki K Hassan-Smith Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Craig L Doig Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Mark Sherlock Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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Paul M Stewart Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK
School of Medicine, Worsley Building, University of Leeds, Leeds, UK

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Gareth G Lavery Institute of Metabolism and Systems Research, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology Diabetes and Metabolism, Birmingham Health Partners, University of Birmingham, Birmingham, UK

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proteasome for hydrolysis ( Lecker et al . 2006 ). It is well established that GCs drive muscle atrophy through modulation of protein metabolism ( McGrath & Goldspink 1982 , Savary et al . 1998 , Biedasek et al . 2011 ). However, the precise molecular

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0011
Volume/Issue:
Volume 229: Issue 3
Free access
Kook Hwan Kim Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea

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Myung-Shik Lee Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea
Severance Biomedical Research Institute, Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei‐ro, Seodaemun‐gu, Seoul 120-752, Korea

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various diseases such as diabetes associated with obesity, liver diseases, muscle atrophy, cardiovascular diseases, and kidney injury. Intriguingly, FGF21 can mediate the therapeutic benefits of several anti-diabetic compounds such as metformin, glucagon

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0160
Volume/Issue:
Volume 226: Issue 1
Free access