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Yan Zhou, Jacob Bendor, Lauren Hofmann, Matthew Randesi, Ann Ho and Mary Jeanne Kreek

anterior pituitary, the regions associated with HPA regulation, we also measured POMC and CRH type 1 receptor (CRH-R1) mRNA levels. The orexins/hypocretins are neuropeptides that are mainly expressed in cells of the lat.hyp ( de Lecea et al. 1998

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Kanta Kon, Hiroshi Tsuneki, Hisakatsu Ito, Yoshinori Takemura, Kiyofumi Sato, Mitsuaki Yamazaki, Yoko Ishii, Masakiyo Sasahara, Assaf Rudich, Takahiro Maeda, Tsutomu Wada and Toshiyasu Sasaoka

orexin to the neurogenic hypertension in BPH/2J mice . Hypertension 959 – 969 . ( https://doi.org/10.1161/HYPERTENSIONAHA.115.07053 ) 26975709 Jöhren O 2018 Orexins/hypocretins and sex . Peptides 115 – 116 . ( https://doi.org/10.1016/j

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J E Digby, J Chen, J Y Tang, H Lehnert, R N Matthews and H S Randeva

, Scruggs P & Dun NJ 2001 Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro . American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 281 R1801 –R1807. Beck

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M Skrzypski, M Billert, K W Nowak and M Z Strowski

cascades of orexin/hypocretin receptors . Biochimie 96 158 – 165 . ( https://doi.org/10.1016/j.biochi.2013.06.015 ) 10.1016/j.biochi.2013.06.015 23810911 Kukkonen JP Leonard CS 2014 Orexin/hypocretin receptor signalling cascades . British

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Mio Tanaka, Morio Azuma, Yumika Nejigaki, Yumiko Saito, Kanta Mizusawa, Minoru Uchiyama, Akiyoshi Takahashi, Seiji Shioda and Kouhei Matsuda

the brain of a pleuronectiform fish, the barfin flounder . Cell and Tissue Research 311 71 – 77 . Amiya N Amano M Oka Y Iigo M Takahashi A Yamamori K 2007 Immunohistochemical localization of orexin/hypocretin-like immunoreactive

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Marc Schneeberger, Ramon Gomis and Marc Claret

Moorman DE Sartor GC Aston-Jones G 2010 Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity . Physiology & Behavior 100 419 – 428 . ( doi:10.1016/j.physbeh.2010.03.009 ) Challis BG Pinnock SB Coll AP Carter RN Dickson SL O

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Patricia Joseph-Bravo, Lorraine Jaimes-Hoy and Jean-Louis Charli

-Araujo E Fugger L Broberger C Burdakov D 2009 Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone . Journal of Physiology 587 1179 – 1186 . ( doi:10.1113/jphysiol.2008.167940 ) de Gortari P Mancera K Martínez A

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Esther Isorna, Nuria de Pedro, Ana I Valenciano, Ángel L Alonso-Gómez and María J Delgado

: assessing function in a phylogenetic context . General and Comparative Endocrinology 203 146 – 157 . ( doi:10.1016/j.ygcen.2014.02.002 ) López JM Sanz-Morello B González A 2014 Organization of the orexin/hypocretin system in the brain