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Anna E Bollag, Tianyang Guo, Ke-Hong Ding, Vivek Choudhary, Xunsheng Chen, Qing Zhong, Jianrui Xu, Kanglun Yu, Mohamed E Awad, Mohammed Elsalanty, Maribeth H Johnson, Meghan E McGee-Lawrence, Wendy B Bollag and Carlos M Isales

determine the effect that the drug has on the production of cytoprotective genes and proteins. In vivo , female C57BL/6 mice were subjected to ovariectomy to increase reactive oxygen species generation to mimic the aging process and simulate menopause

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Sarit Ben-Shmuel, Eyal J Scheinman, Rola Rashed, Zila Shen Orr, Emily J Gallagher, Derek LeRoith and Ran Rostoker

exhibit glucose intolerance and insulin resistance, along with increased weight gain and fat mass ( Heine et al . 2000 ). In this study, we investigated whether the removal of ovarian hormones (including estradiol) by ovariectomy could exacerbate the mild

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María Andrea Camilletti, Alejandra Abeledo-Machado, Jimena Ferraris, Pablo A Pérez, Erika Y Faraoni, Daniel Pisera, Silvina Gutierrez and Graciela Díaz-Torga

ovariectomy. In addition, using pharmacological tools (GPER agonist and antagonist) the involvement of GPER in the regulation of PRL release was studied in vitro and ex vivo , in the GH3 cell line and in rat pituitaries respectively. Materials and

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Sandra Zárate, Mariana Astiz, Natalia Magnani, Mercedes Imsen, Florencia Merino, Silvia Álvarez, Analía Reinés and Adriana Seilicovich

atresia and its associated decline in estradiol levels. Rather, middle-aged acyclic rats are in a state of persistent estrus with chronically high estradiol levels and thus are not considered a good model for reproductive aging. Instead, ovariectomy has

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Eun-Kyung Choi, Woon-Ki Kim, Ok-Joo Sul, Yun-Kyung Park, Eun-Sook Kim, Jae-Hee Suh, Rina Yu and Hye-Seon Choi

Introduction Menopause increases the incidence of metabolic diseases. The loss of ovarian function is associated with increased visceral fat along with metabolic pathologies due to chronic inflammation ( Shoelson et al . 2007 ). The ovariectomy

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Matthias R Meyer, Natalie C Fredette, Matthias Barton and Eric R Prossnitz

Use Committee and carried out in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. To study the role of endogenous estrogens, animals underwent ovariectomy or sham surgery using isoflurane anesthesia at

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Gabriela Capllonch-Amer, Miquel Sbert-Roig, Bel M Galmés-Pascual, Ana M Proenza, Isabel Lladó, Magdalena Gianotti and Francisco J García-Palmer

( n =6), and OVX supplemented with E 2 (OVX+E 2 , n =6). Ovariectomy and sham surgery were performed at 5 weeks of age at Charles River Laboratories. Animals were housed in a controlled environment (22 °C and 65±3% humidity) under a 12 h light:12 h

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Ke Ke, Ok-Joo Sul, Soo-Wol Chung, Jae-Hee Suh and Hye-Seon Choi

between bone and immune system, postmenopausal osteoporosis could be an example reflecting mutual influence of immune system, bone and endocrine system ( Ginaldi & De Martinis 2016 ). Ovariectomy (OVX) in mice is a commonly accepted model reflecting the

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Guillaume Mabilleau, Benoit Gobron, Aleksandra Mieczkowska, Rodolphe Perrot and Daniel Chappard

ovariectomy-induced bone fragility as compared to alendronate. Materials and methods Reagents All GIP analogues were purchased from GeneCust Europe with a purity >95% (Dudelange, Luxembourg). Purity has been verified by high-performance liquid

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R. D. PEPPLER

Departments of Anatomy and Obstetrics and Gynecology, Louisiana State University Medical Center, New Orleans, Louisiana 70112, U.S.A.

(Received 22 April 1976)

The albino rat ovulates 15–18 h after parturition during the dark period (Johnson, Zarrow & Denenberg, 1974) and the hormonal interrelationship preceding this post-partum ovulation is similar to that found at pro-oestrus in the normal cycle (Labhsetwar & Watson, 1974). Chatterjee & Greenwald (1971) have shown that unilateral ovariectomy of pregnant rats on days 1, 10 or 15 produces increased numbers of antral follicles within 5 days and compensatory ovulation at the post-partum oestrus. The specific time after which the pregnant rat can no longer respond to unilateral ovariectomy by increasing the number of ova shed from the remaining ovary at the post-partum ovulation has not previously been evaluated. The present experiments were therefore designed to determine this time. Furthermore, such findings would elucidate, physiologically, when those follicles which