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Jackson Nteeba, Kaiyu Kubota, Wenfang Wang, Hao Zhu, Jay L Vivian, Guoli Dai and Michael J Soares

). PRL and PLs act on their target cells through binding and activating the PRLR ( Bole-Feysot et al. 1998 , Soares 2004 ). The PRLR is a transmembrane receptor expressed in myriad of cell types throughout the body, including the pancreas ( Bole

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Brit H Boehmer, Sean W Limesand and Paul J Rozance

are limited. As a result, animal models are used to investigate the mechanistic link between placental insufficiency and the endocrine pancreas phenotype ( Green et al. 2010 ). Similar to IUGR humans, animal models of placental insufficiency and IUGR

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Claudia E Robert-Cooperman, Grace C Dougan, Shari L Moak, Mark G Athanason, Melanie N Kuehl, Harris Bell-Temin, Stanley M Stevens Jr and Brant R Burkhardt

context of the observed in vivo tissue distribution of PANDER. Therefore, to further elucidate the physiologic role of pancreas-secreted PANDER in vivo , our laboratory has created and phenotyped the only transgenic mouse model (PANDER transgenic, PANTG

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Jennifer A Crookshank, Daniel Serrano, Gen-Sheng Wang, Christopher Patrick, Baylie S Morgan, Marie-France Paré and Fraser W Scott

reasons why the β-cells are targeted and when this begins are unclear ( Atkinson et al. 2015 ). Individuals who develop T1D have a smaller pancreas than nondiabetic individuals and studies indicate involvement of both endocrine and exocrine pancreas

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G Burnstock and I Novak

Introduction The pancreas performs both exocrine and endocrine functions. The bulk of the pancreas is exocrine, comprising 70–90% acinar cells and 5–25% duct cells, depending on the species. Endocrine cells in the islets of Langerhans contribute

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Joshua A Kulas, Kendra L Puig and Colin K Combs

peripheral tissues including intestinal and adipose tissue ( Sondag & Combs 2010 , Puig et al. 2012 , 2015 , Puig & Combs 2013 ). The pancreas has an essential role in the regulation of blood glucose levels, primarily through the secretion of the

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Sandra K Szlapinski, Anthony A Botros, Sarah Donegan, Renee T King, Gabrielle Retta, Brenda J Strutt and David J Hill

Introduction Pregnancy presents as a unique situation of endocrine pancreas β-cell adaptation that reverses after parturition. Late pregnancy is characterized by a state of peripheral maternal insulin resistance mediated by placental hormones

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Maureen J Charron and Patricia M Vuguin

S Billestrup N Madsen OD Serup P Heimberg H Mansouri A 2009 The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into α and subsequently β cells . Cell 138 449 – 462 . ( doi:10.1016/j.cell.2009

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L Banaei-Bouchareb, M Peuchmaur, P Czernichow and M Polak

Introduction The pancreas develops from the fusion of distinct, endoderm-derived, dorsal and ventral diverticula ( Slack 1995 ). In man, by day 35 (5 weeks) of development, the ventral pancreatic bud begins to migrate backward; it

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Angélica Morales, Sumiko Morimoto, Lorenza Díaz, Guillermo Robles and Vicente Díaz-Sánchez

prostate carcinogenesis ( Pasquali et al . 2006 ), and we have recently demonstrated the expression of EG-VEGF in normal human pancreas and pancreatic adenocarcinoma ( Morales et al . 2007 a ). Epidemiologically, pancreatic carcinogenesis is more frequent