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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

-induced TLR4 signaling ( Harii et al . 2005 , McCall et al . 2007 , 2010 , 2013 , Schwartz et al . 2009 , Deosarkar et al . 2014 ). Our lead compound, phenylmethimazole (C10), is a derivative of methimazole that inhibits inflammation resulting from

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Cesidio Giuliani, Ines Bucci, Valeria Montani, Dinah S Singer, Fabrizio Monaco, Leonard D Kohn, and Giorgio Napolitano

of methimazole (MMI) and 5-phenylmethimazole (C10). In the present study, we have investigated the mechanisms of action of MMI and C10 on MHC class-I and class-II gene expression. C10 was more effective than MMI in the transcriptional down

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Kelly D McCall, Dawn Holliday, Eric Dickerson, Brian Wallace, Anthony L Schwartz, Christopher Schwartz, Christopher J Lewis, Leonard D Kohn, and Frank L Schwartz

. We have previously shown that phenylmethimazole (C10) is effective in blocking toll-like receptor (TLR)-mediated activation of inflammatory pathways in non-immune cells ( Dagia et al . 2004 , Harii et al . 2005 , McCall et al . 2007 , Schwartz