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Benoit Cox, Emma Laporte, Annelies Vennekens, Hiroto Kobayashi, Charlotte Nys, Indra Van Zundert, Hiroshi Uji-i, Alizée Vercauteren Drubbel, Benjamin Beck, Heleen Roose, Matteo Boretto and Hugo Vankelecom

Introduction The pituitary represents the master endocrine gland, producing hormones that are key regulators of fundamental physiological processes including body growth, fertility, metabolism, immunity and stress. The gland produces these

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Sara Pepe, Márta Korbonits and Donato Iacovazzo

Introduction The human pituitary gland consists of an anterior lobe, which derives from the oral ectoderm, and a posterior lobe, which originates from the neuroectoderm. The anterior pituitary contains five types of endocrine cells, including

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Wenxia He, Xiangyan Dai, Xiaowen Chen, Jiangyan He and Zhan Yin

Introduction The pituitary gland is a central endocrine gland that regulates the function of other organs and responds to the hypothalamic centers involved in processing external and internal stimuli. The pituitary gland of teleost fish is unique

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Scott Haston, Saba Manshaei and Juan Pedro Martinez-Barbera

Introduction The pituitary gland is known as the master regulator of the endocrine system, a title that is justified by the numerous critical physiological functions that it regulates including growth, metabolism, stress responses and

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Xin Li, Hongjiao Li, Di Zhang, Guojin Xu, Jinglin Zhang and Sheng Cui

Introduction The pituitary gland, a ‘master gland’ of the body, acts as a central endocrine regulator of growth ( Brinkmeier et al. 2009 , Musumeci et al. 2015 , Cox et al. 2017 ), reproduction ( Brown & Roberson 2017 ), metabolism

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María Andrea Camilletti, Alejandra Abeledo-Machado, Jimena Ferraris, Pablo A Pérez, Erika Y Faraoni, Daniel Pisera, Silvina Gutierrez and Graciela Díaz-Torga

Introduction The involvement of estrogens in the control of pituitary function has been extensively studied (reviewed in Seilicovich 2010 ). Initially, estradiol was described to induce lactotroph proliferation through ERα; however, apoptotic

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Alejandro Ibáñez-Costa, Esther Rivero-Cortés, Mari C Vázquez-Borrego, Manuel D Gahete, Luis Jiménez-Reina, Eva Venegas-Moreno, Andrés de la Riva, Miguel Ángel Arráez, Inmaculada González-Molero, Herbert A Schmid, Silvia Maraver-Selfa, Inmaculada Gavilán-Villarejo, Juan Antonio García-Arnés, Miguel A Japón, Alfonso Soto-Moreno, María A Gálvez, Raúl M Luque and Justo P Castaño

Introduction Pituitary tumors are generally benign adenomas from a monoclonal/oligoclonal origin, which display heterogeneous clinical manifestations derived from oversecretion of a single hormone and/or size effects due to excess growth

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Takehiro Tsukada, Morio Azuma, Kotaro Horiguchi, Ken Fujiwara, Tom Kouki, Motoshi Kikuchi and Takashi Yashiro

pituitary gland. Our group has identified various collagen types (type I, III, IV, and VI collagens) in rat anterior pituitary gland ( Kaidzu et al. 2000 ). These collagens are distributed around endocrine cells and capillaries and support tissue

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Cuili Wang, Dongteng Liu, Weiting Chen, Wei Ge, Wanshu Hong, Yong Zhu and Shi X Chen

Introduction Gonadal steroid hormones play key roles in regulating gametogenesis, but they also exert both positive and negative feedback effects at the hypothalamic and pituitary levels. In tetrapod vertebrates, progesterone (P4) is the

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Chengyuan Lin, Xue Jiang, Mulan He, Ling Zhao, Tao Huang, Zhaoxiang Bian and Anderson O L Wong

Introduction Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the secretin/glucagon family, is a 38-amino acid (a.a.) peptide isolated from ovine hypothalamus with stimulatory activity on cAMP production in rat pituitary