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Colin P Sibley

Introduction By the end of pregnancy the human placenta is the largest endocrine organ in a woman, secreting large quantities of an array of hormones into both maternal and fetal plasma ( Costa 2016 ). These hormones control maternal

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Bethany R L Aykroyd, Simon J Tunster, and Amanda N Sferruzzi-Perri

-long health complications including metabolic and cardiovascular dysfunction ( Fowden et al. 2006 , Gluckman et al. 2008 , Camm et al . 2018 ). The placenta is a main determinant of materno-fetal nutrient allocation. It controls nutrient transport

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Ankana Ganguly, Jennifer A Tamblyn, Sarah Finn-Sell, Shiao-Y Chan, Melissa Westwood, Janesh Gupta, Mark D Kilby, Stephane R Gross, and Martin Hewison

Introduction The human placenta is a vital organ without which the mammalian fetus cannot survive. It forms the interface between the mother and fetus, supplying the fetus with oxygen, nutrients, excreting waste products, while protecting

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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum, and V White

, which leads to enhanced lipid transfer through the placenta to the developing fetus. The placenta acts like a supplier and an exchange organ of oxygen, nutrients, and water. It also provides hormones and growing factors that modulate fetal and placental

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Yuehui Zhang, Min Hu, Wenyan Jia, Guoqi Liu, Jiao Zhang, Bing Wang, Juan Li, Peng Cui, Xin Li, Susanne Lager, Amanda Nancy Sferruzzi-Perri, Yanhua Han, Songjiang Liu, Xiaoke Wu, Mats Brännström, Linus R Shao, and Håkan Billig

.5 to 13.5 and found that this triggered many features of PCOS (including HAIR) and lead to fetal loss. The fetal loss was related to disrupted reactive oxygen species (ROS) production in the uterus and placenta of rat dams with induced HAIR. Maternal

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Ching-Wen Chang, Anna K Wakeland, and Mana M Parast

Introduction: placental development begins under low oxygen tension Placenta is a unique organ that connects the fetus to the uterine wall, while providing essential support functions like nutrient uptake and oxygen exchange for the developing

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Ankana Ganguly, Jennifer A Tamblyn, Alexandra Shattock, Annsha Joseph, Dean P Larner, Carl Jenkinson, Janesh Gupta, Janesh R Gross, and Martin Hewison

( Wang et al. 2010 ). Megalin is present at several extra-renal sites ( Lundgren et al. 1997 ), including the placenta ( Burke et al. 2013 ), where its expression is coincident with DBP ( Ma et al. 2012 ). Both maternal decidua and fetal

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Muhammad Furqan Bari, Sherry Ngo, Claire C Bastie, Allan M Sheppard, and Manu Vatish

placenta-derived molecules implicated in the manifestation of insulin resistance associated with GDM ( Desoye & Hauguel-de Mouzon 2007 ). The key functioning unit of the placenta is the chorionic villus, in which a multi-nucleated trophoblast (comprising of

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K M Jeckel, A C Boyarko, G J Bouma, Q A Winger, and R V Anthony

1986 , Barker et al . 1989 , 1990 , 1993 a , b , Gagnon 2003 ). Functional placental insufficiency accounts for at least half of IUGR cases when the fetus is normally formed ( Ghidini 1996 ). As the placenta mediates the exchange of nutrients

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Jacqueline M Wallace

pregnancy, possibly due to deficits in the paracrine actions of the hormone within the placenta ( Jeckel et al. 2018 ). In addition to low CSH concentrations, overnourished dams are typified by low placental reproductive steroid concentrations. This may