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Rebecca M Reynolds and Adrienne Gordon

. 2017 ). Obesity impacts on health of women across their reproductive lifespan with adverse effects on not only fertility and short-term complications of pregnancy, but also on longer-term health outcomes for both women and their children. Here, we

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Michaela D Wharfe, Peter J Mark, Caitlin S Wyrwoll, Jeremy T Smith, Cassandra Yap, Michael W Clarke and Brendan J Waddell

Introduction Maternal physiological adaptations are central to pregnancy success, balancing fetal and placental demands with the maintenance of maternal homeostasis. Among these maternal adaptations, enhanced activity of the hypothalamic

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Derek S Boeldt, Mary A Grummer, Ronald R Magness and Ian M Bird

Introduction Pregnancy is a time of dramatic vascular adaptation. Through initial angiogenesis and then sustained vasodilation, the pregnant uterus achieves the biggest drop in vascular resistance of any organ system. This in turn promotes a

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Cassandra C Yap, Michaela D Wharfe, Peter J Mark, Brendan J Waddell and Jeremy T Smith

mouse ( Wharfe et al. 2016 ), and Wharfe and coworkers have also previously demonstrated that clock gene rhythms in the rat liver are altered by pregnancy ( Wharfe et al. 2011 ). Additionally, despite the high estradiol levels during pregnancy, the

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Ankana Ganguly, Jennifer A Tamblyn, Sarah Finn-Sell, Shiao-Y Chan, Melissa Westwood, Janesh Gupta, Mark D Kilby, Stephane R Gross and Martin Hewison

addition to facilitating a good maternal blood supply for nutrition–waste exchange and orchestrating endocrine mediators of pregnancy to maintain maternal physiological changes for an optimal environment for fetal development, the placenta also acts to

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Jacqueline M Wallace

://data.worldbank.org/indicator/sp.ado.tfrt ). Nevertheless, pregnancy during adolescence still accounts for an estimated 11% of all births worldwide with more than 95% of these occurring in developing countries ( https://www.who.int/en/news-room/fact-sheets/detail/adolescent-pregnancy ). The antecedents of

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Dang-Dang Li, Ying-Jie Gao, Xue-Chao Tian, Zhan-Qing Yang, Hang Cao, Qiao-Ling Zhang, Bin Guo and Zhan-Peng Yue

tract, and female reproductive tract ( Stone & Darlington 2002 , Doherty et al . 2011 ). In mammals, most of tryptophan was metabolized along the kynurenine pathway and tryptophan metabolism was closely correlated with pregnancy ( Stone & Darlington

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Yuhui Liu, Le Zhang, Jing Li, Zhongyan Shan and Weiping Teng

damaging for neurodevelopment of the fetus throughout pregnancy ( Morreale et al . 2004 ) and results in permanent and profound effects on neurological functions that contribute to cognitive and neurological impairments ( Bernal et al . 2003 , Tremont

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Elisa Keating, Ana Correia-Branco, João R Araújo, Manuela Meireles, Rita Fernandes, Luísa Guardão, João T Guimarães, Fátima Martel and Conceição Calhau

uncertainty about potential health hazards. In addition, the WHO currently recommends supplementation with 0.4 mg/day of FA to women during pregnancy and the first 3 months post partum . As a result of all these public health policies, it is an emerging

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Christopher M Mulligan and Jacob E Friedman

during pregnancy and their impact on the microbiota of both mother and infant, including their links to early gut colonization and innate immunity in the infants that drive an increased risk for common metabolic diseases. Figure 1 Influential