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Rebecca McGirr, Leonardo Guizzetti and Savita Dhanvantari

Introduction Proglucagon is a prohormone that is expressed in the alpha cells of the pancreas, the L cells of the intestine and in select neurons of the brainstem. In the pancreatic alpha cell, PC2 cleaves proglucagon to yield glucagon ( Rouille et

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Tianru Jin

Introduction The gene that encodes glucagon, namely the proglucagon gene (gcg), was isolated from rodents and humans in the early 1980s ( Bell et al . 1983 a , b , Lopez et al . 1983 , Heinrich et al . 1984 , Irwin 2001 ). The analysis of gcg

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Niamh X Cawley, Guida Portela-Gomes, Hong Lou and Y Peng Loh

, we extend those findings and show yapsin 1-like immunoreactivity exclusively in human pancreatic islet α-cells and that purified yapsin 1 can generate glucagon by processing proglucagon. These results suggest the presence of a yapsin 1-like

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N M Whalley, L E Pritchard, D M Smith and A White

Introduction Like many prohormones, proglucagon is processed in a cell type-specific manner. In the α-cells of the pancreas, proglucagon is processed to glucagon by prohormone convertase 2 (PC2), but it undergoes alternative processing in the L

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Yi Zhao, Tao Liu, Nina Zhang, Fenghua Yi, Qinghua Wang, Ivan George Fantus and Tianru Jin

respectively ( Sander et al. 1997 , St-Onge et al. 1997 , Andersen et al. 1999 , Hussain & Habener 1999 ). The caudal homeobox gene Cdx-2 was demonstrated to be a transactivator for the proglucagon gene (glu) ( Jin & Drucker 1996 , Laser et

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L Friis-Hansen, KA Lacourse, LC Samuelson and JJ Holst

The maturation of many peptide hormones is attenuated in carboxypeptidase E (CPE)-deficient fat/fat mice, leading to a slowly developing, adult-onset obesity with mild diabetes. To determine the contribution of the hormones generated from the proglucagon precursor to this phenotype, we studied the tissue-specific processing of glucagon and glucagon-like peptide-1 (GLP-1) in these mice. In all tissues examined there was a great reduction in mature amidated GLP-1. Furthermore, a lack of CPE attenuates prohormone convertase processing of proglucagon in both the pancreas and the intestine. These findings suggest that defects in proglucagon processing together with other endocrine malfunctions could contribute to the diabetic and obesity phenotype in fat/fat mice.

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Shou-Si Lu, Yun-Li Yu, Hao-Jie Zhu, Xiao-Dong Liu, Li Liu, Yao-Wu Liu, Ping Wang, Lin Xie and Guang-Ji Wang

play is an important role in the regulation of endocrine pancreatic secretion. The intestinal products of the proglucagon gene, glucagon-like peptide-1 (GLP-1), has been shown to contribute significantly to the overall insulin response to oral glucose

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Patrice D Cani, Catherine A Daubioul, Brigitte Reusens, Claude Remacle, Grégory Catillon and Nathalie M Delzenne

participate in decreased lipogenesis and triacylglycerolvery low density lipoprotein (TG-VLDL) secretion ( Kok et al. 1998 a , Delzenne & Williams 2002 ). The fermentation products of dietary fibres have been shown to increase proglucagon mRNA in the colon

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Antonella Amato, Sara Baldassano and Flavia Mulè

Introduction Glucagon-like peptide 2 (GLP2) is a 33 amino acid proglucagon-derived peptide produced by a subset of enteroendocrine cells (L-cells) residing within the epithelium of the small and large intestine ( Yusta et al . 2000 ). GLP2 is

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Can Liu, Mian Zhang, Meng-yue Hu, Hai-fang Guo, Jia Li, Yun-li Yu, Shi Jin, Xin-ting Wang, Li Liu and Xiao-dong Liu

). Quantitative RT-PCR Quantitative RT-PCR was used to measure Gcg mRNA (for proglucagon gene) and Pcsk1 mRNA (for prohormone convertase 3 ( Pc3 ) gene) in rat ileum (on day 28) or human NCI-H716 cells (incubated with Rb1 for 24 h). Briefly, total RNA from