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Yuhui Liu, Le Zhang, Jing Li, Zhongyan Shan and Weiping Teng

memory is encoded, consolidated, and stored ( Vara et al . 2003 ). The maturation and function of the hippocampus are dependent on thyroid hormone ( Gerges & Alkadhi 2004 ). Congenital hypothyroidism can reduce the expression of many proteins in the

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Henrik Ortsäter, Nina Grankvist, Richard E Honkanen and Åke Sjöholm

( Ashcroft & Rorsman 2012 , Rorsman & Braun 2013 ). Introduction to reversible protein phosphorylation and protein phosphatases In 1992, the Nobel Prize in Physiology or Medicine was awarded jointly to Edmond H Fischer and Edwin G Krebs, for their earlier

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Andrew W Stoker

multicellularity and we are learning an ever-increasing amount about the molecules and processes involved. One cornerstone of intracellular signalling rests on the ability of proteins to be reversibly phosphorylated by protein kinases and protein phosphatases. Such

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Shengyi Sun, Elissa W P Wong, Michelle W M Li, Will M Lee and C Yan Cheng

spermatids in the seminiferous epithelium during spermiogenesis and spermiation, and the transit of primary preleptotene spermatocytes across the BTB. Such dynamics are mediated, at least in part, via changes in the protein–protein interactions between

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G R Guy, R A Jackson, P Yusoff and S Y Chow

the pathway is subjected to multiple positive and negative signals and can be clustered together by a range of docker and scaffold proteins in a temporal or spatial manner within the cell ( Brown & Sacks 2009 ). Moreover, many aberrations in this

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Joshua A Kulas, Kendra L Puig and Colin K Combs

al. 2012 , Crane et al. 2013 ). One protein thought to be critical in the development of AD is Aβ, a self-aggregating peptide cleaved from the larger amyloid precursor protein (APP) ( Goldgaber et al. 1987 , Selkoe et al. 1988 ). APP is a

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Hsien-Yeh Chou, Namasivayam Elangovan, Ying-Chu Lee, Hsiou Hsia Lin and Sin-Tak Chu

proteins are involved in a variety of physiological processes ( Bratt 2000 , Logdberg & Wester 2000 , Devireddy et al. 2001 ). There is less knowledge regarding the mechanisms by which lipocalins exert their biological effects. But, it is well accepted

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Daniel Nyqvist, Göran Mattsson, Martin Köhler, Varda Lev-Ram, Arne Andersson, Per-Ola Carlsson, Astrid Nordin, Per-Olof Berggren and Leif Jansson

Introduction The green fluorescent protein (GFP) from the jellyfish, Aequorea victoria , and its derivatives are today used in numerous hybrid proteins as cellular reporters. Ever since the first use of the wild-type GFP as an

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Barbara J Clark

Introduction Lipid transport proteins play an important role in non-vesicular trafficking of cholesterol, phospholipids, and sphingolipids between biological membranes to help maintain the proper cholesterol:phospholipid:sphingolipid distribution

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Christopher J Delvecchio and John P Capone

homeostasis have been identified. These include the ATP-binding cassette (ABC) transporters, ABCA1, ABCG1, ABCG5 and ABCG8, lipoprotein and lipoprotein-remodeling enzymes such as apolipoprotein E, lipoprotein lipase, cholesterol ester transfer protein as well