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Irene Andrés-Blasco, Andrea Herrero-Cervera, Ángela Vinué, Sergio Martínez-Hervás, Laura Piqueras, María Jesús Sanz, Deborah Jane Burks and Herminia González-Navarro

. Hypertriglyceridemia and high levels of non-esterified fatty acids (NEFA) in the MetS promote abnormal accumulation of lipids within the liver, in a form of steatosis or non-alcoholic fatty liver disease (NAFLD) ( Bugianesi et al . 2005 ). Thus, NAFLD affects up to 90

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Jie Wei, Xia Sun, Yajie Chen, Yuanyuan Li, Liqiong Song, Zhao Zhou, Bing Xu, Yi Lin and Shunqing Xu

inhalation of low levels of ambient air particulate matter (PM 2.5) has been was reported to induce hepatic steatosis and lipid peroxidation and, moreover, increase hepatic inflammatory and fibrosis stage in mice ( Tomaru et al . 2007 , Tan et al . 2009

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Xuemei Tang, Jingwen Li, Wei Xiang, Ye Cui, Bin Xie, Xiaodong Wang, Zihui Xu and Lixia Gan

with the chow diet mice ( Fig. 5A1 ), and metformin treatment reduced hepatic steatosis ( Fig. 5A4 and A6 ). In consistence, hepatic TG ( Fig. 5B ) are increased by HF, levels of which are significantly decreased after metformin treatment and with a

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Jenny D Y Chow, Margaret E E Jones, Katja Prelle, Evan R Simpson and Wah Chin Boon

Introduction Non-alcoholic fatty liver disease (NAFLD) describes a spectrum of progressive liver abnormalities, ranging from benign hepatic steatosis to the more severe non-alcoholic steatohepatitis (NASH) and cirrhosis ( Adams & Angulo 2006

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Abigail Wolf Greenstein, Neena Majumdar, Peng Yang, Papasani V Subbaiah, Rhonda D Kineman and Jose Cordoba-Chacon

Introduction Non-alcoholic fatty liver disease (NAFLD) is defined as excessive accumulation of fat (steatosis) within hepatocytes that is independent of alcohol intake. NAFLD increases the risk of diabetes, non-alcoholic steatohepatitis (NASH

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Jin-Bong Lee, Sung-Jin Yoon, Sang-Hyun Lee, Moo-Seung Lee, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Inpyo Choi, Ik-Soo Kim, Su Wol Chung, Hee Gu Lee, Jeong-Ki Min and Young-Jun Park

. 2017 ). In our study, we found that Rg3 improved insulin sensitivity and ameliorated hepatic steatosis in the mouse model and reduced lipid accumulation in the cell culture model, acting though as the STAT5-PPAR axis. Based on the results, we suggest

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Raquel Barbuio, Marciane Milanski, Manoel B Bertolo, Mário J Saad and Lício A Velloso

Introduction Non-alcoholic fatty liver disease (NAFLD) comprehends a large spectrum of clinicopathological conditions of the liver, ranging from steatosis to cirrhosis, and including steatohepatitis (NASH) and fibrosis ( Browning

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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz and Kelly D McCall

). Specifically, NAFLD is a disease of excess fat accumulation in the liver of individuals with no history of alcohol abuse, which can range from benign steatosis to advanced steatohepatitis (NASH) and cirrhosis ( El-Serag & Kanwal 2014 ). NASH is associated with

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Paramita M Ghosh, Zhen-Ju Shu, Bing Zhu, Zhongding Lu, Yuji Ikeno, Jeffrey L Barnes, Chih-Ko Yeh, Bin-Xian Zhang, Michael S Katz and Amrita Kamat

), includes a spectrum of pathological conditions ranging from hepatic steatosis, or augmented fat accumulation in the liver, through steatohepatitis, cirrhosis, and hepatocellular carcinoma ( Clark 2006 , Kotronen et al . 2007 , Stefan et al . 2008

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Caroline E Geisler and Benjamin J Renquist

2 diabetes and metabolic syndrome in recent decades ( Tuyama & Chang 2012 , Yki-Jarvinen 2016 ). NAFLD encompasses hepatic steatosis driven by factors other than excessive alcohol consumption and is estimated to affect 25% of the global population