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Daniel M Kelly and T Hugh Jones

than twofold. This led to the belief that testosterone per se exerts a detrimental influence upon the cardiovascular system; however, evidence has emerged over recent years to suggest that a number of the cellular mechanisms intimate to the

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Bo-Kyung Son, Taro Kojima, Sumito Ogawa and Masahiro Akishita

Introduction With advancing age, circulating testosterone declines gradually in men ( Feldman et al. 2002 , Liu et al. 2007 ). This decline has been suggested to be causally related to poor health outcomes, including increased risk of

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Mathis Grossmann

Introduction: significance of the clinical problem Around 50% of ageing, obese men presenting to the diabetes clinic have lowered testosterone levels relative to reference ranges based on healthy young men ( Grossmann 2011 ). Many have symptoms

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Weiwei Xu, Jamie Morford and Franck Mauvais-Jarvis

hormone testosterone in males and females ( Navarro et al . 2015 , Morford & Mauvais-Jarvis 2016 , Schiffer et al . 2017 , Morford et al . 2018 ). It is well established that testosterone deficiency predisposes men to visceral obesity, metabolic

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Lei Li, Ping Ma, Chen Huang, Yongjun Liu, Ye Zhang, Chen Gao, Tianxia Xiao, Pei-Gen Ren, Brian A Zabel and Jian V Zhang

)-induced testosterone production in rat testis, while resistin-stimulated testosterone production in rat testis ( Tena-Sempere et al . 1999 , Nogueiras et al . 2004 ). Recent reports point to a role of the novel adipokine chemerin in reproduction as well, focusing on

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Fengyue Wang, Jing Yang, Junfeng Sun, Yanli Dong, Hong Zhao, Hui Shi and Lu Fu

Introduction Testosterone, a steroid hormone, affects the cardiovascular system. Results of epidemiological studies have indicated that testosterone deficiency is highly prevalent in men with cardiovascular disease (CVD) and is negatively

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Suwattanee Kooptiwut, Wanthanee Hanchang, Namoiy Semprasert, Mutita Junking, Thawornchai Limjindaporn and Pa-thai Yenchitsomanus

al . 2009 ). Results from previous studies have indicated that testosterone replacement therapy ameliorated insulin resistance and improved glycemic control in hypogonadal men with T2D ( Kapoor et al . 2006 ). Also, testosterone treatment has been

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Arnaud Jean, Anne-Charlotte Trouillet, Njiva Andry Andrianarivelo, Sakina Mhaouty-Kodja and Hélène Hardin-Pouzet

al. 2009 ), which can be activated by testosterone (T) or its metabolite dihydrotestosterone (DHT). mPOA also expresses ERα ( Swaney et al. 2012 ) and ERβ ( Orikasa et al. 2002 ) activated by oestradiol (E2), which can be produced by neural

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Patricia K Russell, Salvatore Mangiafico, Barbara C Fam, Michele V Clarke, Evelyn S Marin, Sofianos Andrikopoulos, Kristine M Wiren, Jeffrey D Zajac and Rachel A Davey

Introduction There are abundant data that fat mass is negatively regulated by androgens in men. Hypogonadal men with low serum testosterone levels have increased visceral obesity compared to men with normal serum testosterone ( Bhasin et al

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William Zawatski and Mary M Lee

, which in turn drives testosterone production by testicular Leydig cells (see Fig. 1 ). Short bursts of LH release occur nocturnally early in puberty, accompanied by nighttime elevations in serum testosterone. GNRH also increases FSH secretion, which