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Cyril S Anyetei-Anum
Cyril S Anyetei-Anum
Department of Biology, College of William and Mary, Williamsburg, Virginia, USA
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Vincent R Roggero
Vincent R Roggero
Department of Biology, College of William and Mary, Williamsburg, Virginia, USA
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Lizabeth A Allison
Lizabeth A Allison
Department of Biology, College of William and Mary, Williamsburg, Virginia, USA
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, Mullur et al . 2014 , Mondal et al . 2016 , Mendoza & Hollenberg 2017 , van der Spek et al . 2017 ). Much of thyroid hormone action is mediated by the thyroid hormone receptors (TRs), members of the nuclear receptor superfamily that act as ligand
Ángela Sánchez
Ángela Sánchez
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
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Constanza Contreras-Jurado
Constanza Contreras-Jurado
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
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Diego Rodríguez
Diego Rodríguez
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
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Javier Regadera
Javier Regadera
Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, Madrid, Spain
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Susana Alemany
Susana Alemany
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
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Ana Aranda
Ana Aranda
Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
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triiodothyronine (T3) are initiated by binding to the nuclear thyroid hormone receptors (TRs), encoded by the TRα and TRβ genes, which result in several isoforms with different expression and functions ( Aranda & Pascual 2001 , Aranda et al . 2013 , Pascual
J Kwakkel
J Kwakkel
Department of Endocrinology and Metabolism, Academic Medical Center F5-165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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W M Wiersinga
W M Wiersinga
Department of Endocrinology and Metabolism, Academic Medical Center F5-165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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A Boelen
A Boelen
Department of Endocrinology and Metabolism, Academic Medical Center F5-165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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decreased activity of liver D1 therefore contributes to low serum T 3 levels. TRβ1, one of the thyroid hormone receptors through which T 3 exerts its actions in the liver, is also downregulated in an animal model of NTI. This suggests that impaired T 3
C R Liu
C R Liu
Key Laboratory of Hormones and Development, Department of Pathology, Ministry of Health China, Endocrinology Institute of Tianjin Medical University, Tianjin Medical Institute, Tianjin 300070, China
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L Y Li
L Y Li
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F Shi
F Shi
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X Y Zang
X Y Zang
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Y M Liu
Y M Liu
Key Laboratory of Hormones and Development, Department of Pathology, Ministry of Health China, Endocrinology Institute of Tianjin Medical University, Tianjin Medical Institute, Tianjin 300070, China
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Y Sun
Y Sun
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B H Kan
B H Kan
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-affinity thyroid hormone receptor (TR) located in the nucleus. TR plays an important role in mediating the cardiac physiologic actions of T 3 ( Sussman 2001 , Dillmann 2002 ). Normal thyroid hormone level is essential for maintaining normal heart structure and
Ana Sofia Rocha
Ana Sofia Rocha
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Ricardo Marques
Ricardo Marques
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Inês Bento
Inês Bento
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Ricardo Soares
Ricardo Soares
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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João Magalhães
João Magalhães
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Inês Vieira de Castro
Inês Vieira de Castro
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Paula Soares
Paula Soares
IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s/n, 4200-065 Porto, Portugal
Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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Department of Pathology, Hospital São João, Porto, Portugal
Department of Pathology, Medical Faculty, University of São Paulo, São Paulo, Brazil
Department of Pathology, Medical Faculty, University of Porto, Porto, Portugal
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( Castro et al. 2006 ). At variance with PTC, a mouse model for FTC was lacking until Kaneshige et al. (2000) described a mutant mouse with a mutation ( PV ) targeted to the thyroid hormone receptor β (THRB) locus. In a heterozygous condition
Bénédicte Rabier
Bénédicte Rabier
INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Allan J Williams
Allan J Williams
INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Frederic Mallein-Gerin
Frederic Mallein-Gerin
INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Graham R Williams
Graham R Williams
INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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O Chassande
O Chassande
INSERM U577-Biomatériaux et Réparation Tissulaire, Université Bordeaux 2 Victor Segalen, Zone Nord, Bâtiment 4A, 2ème étage, 33076 Bordeaux Cedex, France
Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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Université Victor Segalen Bordeaux 2, Bordeaux, France
Molecular Endocrinology Group, Division of Medicine, Faculty of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
Laboratoire de Biologie et Ingénierie du Cartilage, Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS/UCBLyon 1, 7 passage du Vercors, 69367 Lyon Cedex 07, France
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. Journal of Bone and Mineral Research 11 105 –113. Amma LL , Campos-Barros A, Wang Z, Vennstrom B & Forrest D 2001 Distinct tissue-specific roles for thyroid hormone receptors beta and alpha1 in regulation of type 1
Cássio M Villicev
Cássio M Villicev
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Fatima R S Freitas
Fatima R S Freitas
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Marcelo S Aoki
Marcelo S Aoki
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Cássio Taffarel
Cássio Taffarel
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Thomas S Scanlan
Thomas S Scanlan
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Anselmo S Moriscot
Anselmo S Moriscot
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Miriam O Ribeiro
Miriam O Ribeiro
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Antonio C Bianco
Antonio C Bianco
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Cecília H A Gouveia
Cecília H A Gouveia
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof Lineu Prestes, 2415 Sao Paulo 05508-900, Brazil
School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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School of Arts, Sciences & Humanities, University of Sao Paulo, Sao Paulo, Brazil
Department of Biosciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
Departments of Pharmaceutical Chemistry & Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, SP, Brazil
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chemistry and Biology 5 299 –306. Danzi S & Klein I 2004 Thyroid hormone and the cardiovascular system. Minerva Endocrinologica 29 139 –150
J Kwakkel
J Kwakkel
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O Chassande
O Chassande
Department of Endocrinology and Metabolism, Academic Medical Center University of Amsterdam, INSERM U 577, Université Victor Segalen Bordeaux 2, F5-165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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H C van Beeren
H C van Beeren
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W M Wiersinga
W M Wiersinga
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A Boelen
A Boelen
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. Table 1 Basal laboratory values of thyroid hormone receptor (TRβ −/− ) and wild-type (WT) mice. Mean values± s.e.m. are given Wild-type TRβ −/− ♀ ♂ ♀ ♂ Serum T 3 (nmol/l) 1.55±0.34 1.34±0.14 2.53±0.24* 2.68±0.21 † Serum T 4 (nmol/l) 67±6 57±4 133
Aline Cordeiro
Aline Cordeiro
Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil
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Luana Lopes Souza
Luana Lopes Souza
Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil
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Marcelo Einicker-Lamas
Marcelo Einicker-Lamas
Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil
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Carmen Cabanelas Pazos-Moura
Carmen Cabanelas Pazos-Moura
Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Centro de Ciências da Saúde, Avenida Carlos Chagas Filho, 373, Bloco G, Cidade Universitária - Ilha do Fundão, Rio de Janeiro - RJ 21941-902, Brazil
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functionally with the thyroid hormone receptor (TR) to regulate malic enzyme gene expression ( Chou et al . 2007 ). The elevated S14 expression is important to increase lipogenic enzyme expressions induced by T 3 ( Cunningham et al . 1998 ). In this way
Gabriela Hernández-Puga
Gabriela Hernández-Puga
Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Querétaro, Mexico
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Arturo Mendoza
Arturo Mendoza
Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Querétaro, Mexico
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Alfonso León-del-Río
Alfonso León-del-Río
Programa de Investigación de Cáncer de Mama y Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, UNAM, México, Mexico
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Aurea Orozco
Aurea Orozco
Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Querétaro, Mexico
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the thyroid hormone receptors (TRs), which promote the activation or repression of a wide collection of genes ( Grøntved et al . 2015 ). Two isoforms for the thrb gene have been identified in teleosts: long or L-Trb1 and short or S-Trb1, which differ
