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Juan Bernal Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Autónoma de Madrid, Madrid, Spain

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Beatriz Morte Center for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

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Diego Diez Immunology Frontier Research Center, Osaka University, Osaka, Japan

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Introduction Thyroid hormones are crucial for brain development, acting through nuclear receptors for T3 to control gene expression ( Brent 2012 , Mendoza & Hollenberg 2017 ). The amount of T3 reaching the nucleus of target cells depends

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0189
Volume/Issue:
Volume 255: Issue 3
Free access
A J Forhead Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK

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A L Fowden Department of Physiology, Department of Biological and Medical Sciences, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK

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Introduction The thyroid hormones, thyroxine (T 4 ) and triiodothyronine (T 3 ), are detectable in the fetal circulation from early in gestation and have important developmental, metabolic, and maturational effects in the fetus in all species

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0025
Volume/Issue:
Volume 221: Issue 3
Free access
Dimitri Novitzky
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David K C Cooper Formerly Professor of Cardiothoracic Surgery, Thomas E. Starzl Transplantation Institute, University of South Florida, Tampa, Florida, USA

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Introduction: thyroid hormone and the euthyroid sick syndrome Thyroid hormone production, function, and interaction with other endocrine systems are well understood ( Flood et al . 2013 , Duarte-Guterman et al . 2014 ). Control of the thyroid

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0389
Volume/Issue:
Volume 223: Issue 1
Free access
Noelia Martínez-Sánchez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José M Moreno-Navarrete CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Cristina Contreras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Eva Rial-Pensado Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José-Manuel Fernández-Real CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Miguel López Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Introduction Thyroid hormones (THs; 3,3′,5,5′ tetraiodothyroxyne or T 4 and 3,3′,5-triiodothyronine or T 3 ) exert important biological actions, not only modulating the development and growth but also regulating metabolism and energy balance

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0425
Volume/Issue:
Volume 232: Issue 2
Open access
J Fahrenkrug Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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B Georg Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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J Hannibal Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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H L Jørgensen Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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thyroid hormones. Studies in rats on the existence of a daily oscillating pattern of thyroid hormones in the circulation have, however, not been quite unequivocal, although most favour a diurnal peak of thyroxin (T4) and triiodothyronine (T3) during the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0111
Volume/Issue:
Volume 233: Issue 3
Open access
Marta Toral Departamento de Farmacología, Facultad de Farmacia, Granada, Spain

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Rosario Jimenez Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Sebastián Montoro-Molina Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

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Miguel Romero Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Rosemary Wangensteen Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, Spain

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Juan Duarte Departamento de Farmacología, Facultad de Farmacia, Granada, Spain
Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain

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Félix Vargas Instituto de Investigación Biosanitaria GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain
Departamento de Fisiología, Facultad de Medicina, Granada, Spain

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A, CAT-2B, CAT-3 and CAT-4), is the major cationic amino acid transport system and accounts for ~60% of the transport of the intracellular supply of L-arginine for NOS ( Verrey et al. 2004 ). Thyroid hormone excess is associated with a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0229
Volume/Issue:
Volume 239: Issue 1
Free access
Aline Cordeiro
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Luana Lopes de Souza
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Lorraine Soares Oliveira
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Larissa Costa Faustino
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Letícia Aragão Santiago
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Flavia Fonseca Bloise
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Tania Maria Ortiga-Carvalho
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Norma Aparecida dos Santos Almeida Biophysics Institute Carlos Chagas Filho, Department of Physiological Sciences, Federal University of Rio de Janeiro, Cidade Universitária - Ilha do Fundão, Avenida Carlos Chagas Filho, 373, Centro de Ciências da Saúde, Bloco G, CEP: 21941-902, Rio de Janeiro, RJ, Brazil

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Carmen Cabanelas Pazos-Moura
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induced by high-fat diet ingestion are attenuated ( Baur et al . 2006 , Feige et al . 2008 , Pfluger et al . 2008 ). However, at this point in time, our knowledge on SIRT1 protein expression regulation is limited. Similar to SIRT1, thyroid hormones

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0420
Volume/Issue:
Volume 216: Issue 2
Free access
P C Lisboa Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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E de Oliveira Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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A C Manhães Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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A P Santos-Silva Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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C R Pinheiro Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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V Younes-Rapozo Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil
Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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L C Faustino Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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T M Ortiga-Carvalho Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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E G Moura Laboratory of Endocrine Physiology, Laboratory of Neurophysiology, Carlos Chagas Filho Biophysic Institute, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro 20551‐030, Brazil

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adrenal function and serum glucocorticoid levels with higher levels of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) in adult offspring whose mothers were nicotine-exposed (Pinheiro et al . 2011). Thyroid hormones (THs), T 4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0473
Volume/Issue:
Volume 224: Issue 3
Free access
Andréa Gonçalves Trentin Departatmento Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, 88040-900, Trindade, Florianópolis, S.C., Brazil

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& Robitaille 2003 , Nedergaard et al. 2003 , Bachoo et al. 2004 ). Astrocytes are mediators of thyroid hormone metabolism in the brain The importance of thyroid hormone for normal brain development is well documented

Article Type:
Review Article
DOI:
https://doi.org/10.1677/joe.1.06680
Volume/Issue:
Volume 189: Issue 2
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Marian Ludgate School of Medicine, Centre for Endocrine and Diabetes Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK

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In a paper entitled ‘Influence of thyroidectomy on thyroxine metabolism and turnover rate in rats’, Nagao et al . (2011) have investigated thyroid hormone kinetics in the hypothyroid state. In a number of carefully performed studies, which rely

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0159
Volume/Issue:
Volume 210: Issue 1
Free access