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Dominique A Glauser Fondation pour Recherches Médicales, University of Geneva, Av. de la Roseraie 64, 1211 Geneva, Switzerland

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Werner Schlegel Fondation pour Recherches Médicales, University of Geneva, Av. de la Roseraie 64, 1211 Geneva, Switzerland

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Part I: introduction to FOXO transcription factors Classification and structure of FOXO proteins FOXO transcription factors form a subclass of the large family of Forkhead proteins characterized by the

Article Type:
Review Article
DOI:
https://doi.org/10.1677/JOE-06-0191
Volume/Issue:
Volume 193: Issue 2
Free access
David W Scoville Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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Kristin Lichti-Kaiser Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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Sara A Grimm Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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Anton M Jetten Cell Biology Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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these results to publicly available data on the genomic binding of several other islet-enriched transcription factors, in order to determine whether GLIS3 regulates pancreatic beta cell gene transcription by binding to distinct regulatory hubs with other

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0182
Volume/Issue:
Volume 243: Issue 1
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Michael Mannstadt Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Emily Holick Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Wenping Zhao Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

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Harald Jüppner Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA
Endocrine Unit, Pediatric Nephrology Unit, Massachusetts General Hospital and Harvard Medical School, Thier 1051, 55 Fruit Street, Boston, Massachusetts 02114, USA

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orthologs of the Drosophila gene glial cells missing) is a transcription factor which is exclusively expressed during embryonic development in the parathyroid-specific domain that later gives rise to the parathyroid glands ( Kim et al . 1998 , Günther

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0247
Volume/Issue:
Volume 210: Issue 2
Free access
Ichiro Kaneko Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA

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Rimpi K Saini Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA

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Kristin P Griffin Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA

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G Kerr Whitfield Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA

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Mark R Haussler Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA

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Peter W Jurutka Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 N. Fifth Street, Phoenix, Arizona 85004, USA

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sensitive to inhibition by cycloheximide ( Kolek et al . 2005 , Haussler et al . 2010 ), suggesting that the transcriptional effect may be secondary and dependent on the induction of an intermediary transcription factor. However, the time course of FGF23

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0225
Volume/Issue:
Volume 226: Issue 3
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Débora Cristina de Moraes
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Mario Vaisman Laboratório de Endocrinologia Molecular, Hospital Universitário Clementino Fraga Filho, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Rio de Janeiro CEP 21949-900, Brasil

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Flavia Lucia Conceição Laboratório de Endocrinologia Molecular, Hospital Universitário Clementino Fraga Filho, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho, s/n, Rio de Janeiro CEP 21949-900, Brasil

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Tânia Maria Ortiga-Carvalho
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( Kioussi et al . 1999 ), Tpit ( Lamolet et al . 2001 ) and Prop1 ( Sornson et al . 1996 ). Figure 2 Temporal and spatial activation of pituitary transcription factors. In response to the BMP2–FGF8 ventral–dorsal gradient, pituitary cell lineages are

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0229
Volume/Issue:
Volume 215: Issue 2
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Jinke Wang The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

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Jie Lu The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

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Guangming Gu The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

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Yingxun Liu The State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, People's Republic of China

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Introduction Transcription factors (TFs) are central to almost every fundamental cellular process ( Latchman 2008 , Ladunga 2010 ) and account for ∼5–10% of genes in eukaryotes ( Reece-Hoyes et al . 2005 , Adryan & Teichmann 2006 , Ho et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0010
Volume/Issue:
Volume 210: Issue 1
Free access
Robert S Viger Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

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Marie France Bouchard Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada

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Jacques J Tremblay Reproduction, Mother and Child Health, Centre de recherche du CHU de Québec-Université Laval, Québec, Quebec, Canada
Centre de recherche en reproduction, développement et santé intergénérationnelle, Department of Obstetrics, Gynecology, and Reproduction, Université Laval, Québec, Quebec, Canada

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STAR gene has been proposed to be regulated by a multitude of DNA-binding and/or -associating transcription factors ( Fig. 1 ), working alone or in combination ( Fig. 2 ), and that interact with regulatory sequences in the STAR promoter with either

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0087
Volume/Issue:
Volume 263: Issue 2
Restricted access
L Grinius Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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C Kessler Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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J Schroeder Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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S Handwerger Department of Endocrinology, Children’s Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA

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Introduction Transcription factors of the forkhead (FOXO) family of DNA-binding proteins are involved in regulation of diverse cellular functions, such as differentiation, metabolism, proliferation, and survival (for review see

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06451
Volume/Issue:
Volume 189: Issue 1
Free access
Eric W-F Lam Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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Kunal Shah Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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Jan J Brosens Cancer Research-UK Laboratories, Institute of Reproductive and Developmental Biology, Division of Cancer and

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of intense tissue remodelling. Among these factors are members of the FOXO family of transcription factors. FOXO proteins, functioning downstream of the phosphoinositol-3-kinase (PI3K)/AKT oncogenic signalling pathway, are central to a diversity of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0480
Volume/Issue:
Volume 212: Issue 1
Free access
Zhihao Liu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Fengrui Wu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Baowei Jiao Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Xiuyue Zhang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Chongjiang Hu Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Baofeng Huang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Linyan Zhou Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Xigui Huang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Zhijian Wang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Yaoguang Zhang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Yoshitaka Nagahama Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Christopher H K Cheng Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Deshou Wang Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Science, Southwest University, Chongqing 400715, China
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Department of Biochemistry and the Environmental Science Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

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Introduction The doublesex and mab-3 (DM)-related transcription factor 1 ( Dmrt1 ) belongs to the DM domain gene family. Among the different phyla of the animal kingdom including vertebrates, it is the only gene found to be conserved

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0135
Volume/Issue:
Volume 194: Issue 1
Free access