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Rong Wan Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Chao Zhu Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Rui Guo Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Lai Jin Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Yunxin Liu Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Li Li Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Hao Zhang Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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Shengnan Li Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, People's Republic of China

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biology, such as modulating local and systemic inflammation. Importantly, both AR and urocortin (UCN1) have been identified in vascular ECs ( Liu et al . 2003 , Kageyama et al . 2012 ). Endothelial UCN1 is upregulated by inflammatory cytokines ( Kohno

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0138
Volume/Issue:
Volume 218: Issue 3
Free access
Sian J S Simpson Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Lorna I F Smith Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Peter M Jones Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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James E Bowe Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Introduction The corticotropin-releasing hormone (CRH) peptide family comprises CRH and the structurally related urocortin peptides (UCN1, UCN2 and UCN3). These neuroendocrine peptides are best known for their involvement in regulating the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0568
Volume/Issue:
Volume 245: Issue 2
Open access
Kenichiro Watanabe Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Takahiro Nemoto Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Shigeo Akira Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Toshiyuki Takeshita Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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& Vale 2006 ). Urocortin 2 (Ucn2) is a member of the CRF peptide family, which acts through binding to CRF type 2 receptor (CRF-R2). Others and we previously demonstrated that Ucn2 is expressed in both the brain and peripheral tissues, including the lung

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0228
Volume/Issue:
Volume 219: Issue 3
Free access
Pasquale Florio Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Giulia De Falco Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Eleonora Leucci Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Michela Torricelli Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Paulo B Torres Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Paolo Toti Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Arianna Dell’Anna Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Ennio Tiso Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Rosa Santopietro Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Lorenzo Leoncini Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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Felice Petraglia Chair of Obstetrics and Gynaecology, Department of Paediatrics, Obstetrics and Reproductive Medicine and
Department of Human Pathology and Oncology, University of Siena, Policlinico ‘Le Scotte’ Viale Bracci, 53100 Siena, Italy

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and secretion of these factors may be involved in pathological conditions, such as endometrial adenocarcinoma. Among the locally produced brain peptides, urocortin (UCN) is one of the most recently identified. It is a 40-amino acid neuropeptide

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06726
Volume/Issue:
Volume 190: Issue 1
Free access
Takahiro Nemoto Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Azusa Iwasaki-Sekino Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Naoko Yamauchi Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Introduction As a member of the corticotropin-releasing factor (CRF) family peptides, urocortin (Ucn 1) was discovered by screening of a rat brain cDNA library with a probe derived from carp urotensin I ( Vaughan et al. 1995

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.07023
Volume/Issue:
Volume 192: Issue 2
Free access
Yuqing Wu Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, P R China

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Yinyan Xu Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, P R China

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Hong Zhou Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, P R China

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Jin Tao Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, P R China

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Shengnan Li Department of Pharmacology, Nanjing Medical University, Nanjing, 210029, P R China

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exerts profound immunosuppressive effects ( Chrousos 1995 ). More recently, a new member of the CRH family, urocortin (UCN), was cloned and shown to be expressed in the central nervous system of rats ( Vaughan et al. 1995 ) and man ( Donaldson et

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06607
Volume/Issue:
Volume 189: Issue 1
Free access
Takahiro Nemoto Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Naoko Yamauchi Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Department of Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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actions of CRF are induced through two subtypes of CRF receptor (CRF-R), the CRF-R1 and the CRF-R2, with a higher affinity to CRF-R1 than to CRF-R2 ( Chen et al . 1993 , Perrin et al . 1993 , Lovenberg et al . 1995 a ). Urocortins 2 (Ucn 2), one of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0467
Volume/Issue:
Volume 201: Issue 1
Free access
Manon M Roustit
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Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Mark E Cleasby
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treatments available. However, recent work has demonstrated that generalised overexpression of urocortin 3 (UCN3) in mice results in both hypertrophy and increased glucose disposal into muscle ( Jamieson et al . 2011 ), making this an interesting candidate

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0181
Volume/Issue:
Volume 223: Issue 2
Open access
Jessica L Huang Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Sharon Lee Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Pelle Hoek Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Talitha van der Meulen Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Richard Van Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA

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Mark O Huising Department of Neurobiology, Physiology & Behavior, College of Biological Sciences, University of California, Davis, California, USA
Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California, USA

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, most beta cells do not express MAFA at this early age and remain largely functionally immature. Additional markers, such as the peptide hormone Urocortin 3 (UCN3), have emerged as late beta cell maturity markers in recent years. UCN3 is a member of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0535
Volume/Issue:
Volume 246: Issue 1
Restricted access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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protein metabolism. Published effects of insulin, insulin-like growth factor 1 (IGF1), amino acids, myostatin, urocortins and vitamin D on signalling pathways and effector machinery (glucose transporters, mitochondrial function, translation and activation

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0533
Volume/Issue:
Volume 229: Issue 2
Open access