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Stephen P Ashcroft
Stephen P Ashcroft
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, UK
Mitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
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MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, UK
Mitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
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Gareth Fletcher
Gareth Fletcher
Mitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
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Ashleigh M Philp
Ashleigh M Philp
Mitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Medicine, UNSW Sydney, New South Wales, Australia
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St Vincent’s Clinical School, UNSW Medicine, UNSW Sydney, New South Wales, Australia
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Carl Jenkinson
Carl Jenkinson
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
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ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia
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Shatarupa Das
Shatarupa Das
Centenary Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
UTS Centenary Centre for Inflammation, University Technology Sydney, New South Wales, Australia
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UTS Centenary Centre for Inflammation, University Technology Sydney, New South Wales, Australia
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Philip M Hansbro
Philip M Hansbro
Centenary Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
UTS Centenary Centre for Inflammation, University Technology Sydney, New South Wales, Australia
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UTS Centenary Centre for Inflammation, University Technology Sydney, New South Wales, Australia
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Philip J Atherton
Philip J Atherton
MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Clinical, Metabolic and Molecular Physiology, University of Nottingham, Royal Derby Hospital Centre, Derby, UK
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Andrew Philp
Andrew Philp
Mitochondrial Metabolism and Ageing Laboratory, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, UNSW Medicine, UNSW Sydney, New South Wales, Australia
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St Vincent’s Clinical School, UNSW Medicine, UNSW Sydney, New South Wales, Australia
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Introduction Vitamin D deficiency, characterised by serum 25-hydroxyvitamin D (25(OH)D) levels of < 50 nmol/L, remains prevalent across both Europe and the United States of America ( Forrest & Stuhldreher 2011 , Cashman et al. 2016
Daniela Leite de Oliveira
Daniela Leite de Oliveira
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
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Camila Hirotsu
Camila Hirotsu
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
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Sergio Tufik
Sergio Tufik
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
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Monica Levy Andersen
Monica Levy Andersen
Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
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Introduction The musculoskeletal benefits of vitamin D are widely known: they promote the calcification of bone matrix and increase the absorption of calcium and phosphate in the intestine. Vitamin D deficiency can cause rickets in children
J A Tamblyn
J A Tamblyn
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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M Hewison
M Hewison
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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C L Wagner
C L Wagner
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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J N Bulmer
J N Bulmer
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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M D Kilby
M D Kilby
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
College of Medical and Dental Sciences, College of Medical and Dental Sciences, Departments of Pediatrics, Reproductive and Vascular Biology Group, Fetal Medicine Centre, Centre for Women's and Children's Health
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of vitamin D at the maternal–fetal interface. Illustration of both the innate and adaptive leukocyte decidual subsets with the potential capacity for intrinsic 1,25-dihydroxyvitamin D (1,25(OH) 2 D) synthesis from 25-hydroxyvitamin D (25OHD
Nathanael J Yates
Nathanael J Yates
School of Human Sciences, The University of Western Australia, Perth, Australia
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Dijana Tesic
Dijana Tesic
School of Human Sciences, The University of Western Australia, Perth, Australia
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Kirk W Feindel
Kirk W Feindel
Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, Australia
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Jeremy T Smith
Jeremy T Smith
School of Human Sciences, The University of Western Australia, Perth, Australia
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Michael W Clarke
Michael W Clarke
Metabolomics Australia, Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Perth, Australia
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Celeste Wale
Celeste Wale
School of Human Sciences, The University of Western Australia, Perth, Australia
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Rachael C Crew
Rachael C Crew
School of Human Sciences, The University of Western Australia, Perth, Australia
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Michaela D Wharfe
Michaela D Wharfe
School of Human Sciences, The University of Western Australia, Perth, Australia
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Andrew J O Whitehouse
Andrew J O Whitehouse
Telethon Kids Institute, The University of Western Australia, Perth, Australia
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Caitlin S Wyrwoll
Caitlin S Wyrwoll
School of Human Sciences, The University of Western Australia, Perth, Australia
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Introduction The quality of early life environment is a powerful determinant of adult health outcomes, including brain function ( Cottrell & Seckl 2009 ). The abundant expression of vitamin D receptors within the foetal brain ( Eyles et al
Ankana Ganguly
Ankana Ganguly
Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
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Jennifer A Tamblyn
Jennifer A Tamblyn
Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK
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Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK
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Sarah Finn-Sell
Sarah Finn-Sell
Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
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Shiao-Y Chan
Shiao-Y Chan
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Melissa Westwood
Melissa Westwood
Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
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Janesh Gupta
Janesh Gupta
Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
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Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
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Mark D Kilby
Mark D Kilby
Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
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Fetal Medicine Centre, Birmingham Women’s NHS Foundation Trust, Birmingham, UK
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Stephane R Gross
Stephane R Gross
School of Life and Health Sciences, Aston University, Birmingham, UK
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Martin Hewison
Martin Hewison
Institute of Metabolism and Systems Research, The University of Birmingham, Birmingham, UK
CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK
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CEDAM, Birmingham Health Partners, The University of Birmingham, Birmingham, UK
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regulation of trophoblast invasion have been well documented ( Menkhorst et al . 2016 ). The aim of the current review is to provide an overview of these early events in placental development, with particular emphasis on the potential role of vitamin D as a
Lauriane Bonnet
Lauriane Bonnet
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
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Esma Karkeni
Esma Karkeni
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
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Charlène Couturier
Charlène Couturier
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
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Julien Astier
Julien Astier
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
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Catherine Defoort
Catherine Defoort
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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Ljubica Svilar
Ljubica Svilar
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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Franck Tourniaire
Franck Tourniaire
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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Lourdes Mounien
Lourdes Mounien
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
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Jean-François Landrier
Jean-François Landrier
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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CriBioM, Criblage Biologique Marseille, Faculté de Médecine de la Timone, Marseille, France
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Introduction Low levels of total circulating 25-hydroxy-vitamin D (25(OH)D) are strongly associated with obesity and more specially with increased fat mass and BMI ( Vilarrasa et al. 2007 , Earthman et al. 2012 , Landrier et al. 2016
Kevin J P Ryan
Kevin J P Ryan
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK
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Zoe C T R Daniel
Zoe C T R Daniel
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK
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Lucinda J L Craggs
Lucinda J L Craggs
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK
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Tim Parr
Tim Parr
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK
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John M Brameld
John M Brameld
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK
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Introduction Vitamin D (VitD) is a key nutrient for maintaining the health of the musculoskeletal system, with VitD deficiency leading to myopathy, classically characterised by hypotonia, weakness and atrophy of skeletal muscle, and a deterioration
Ida Marie Boisen
Ida Marie Boisen
Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
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John Erik Nielsen
John Erik Nielsen
Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
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Lieve Verlinden
Lieve Verlinden
Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium
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Mette Lorenzen
Mette Lorenzen
Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
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Rune Holt
Rune Holt
Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
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Anja Pinborg
Anja Pinborg
The Fertility Clinic, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Christine Hjorth Andreassen
Christine Hjorth Andreassen
Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Beate Lanske
Beate Lanske
Division of Bone and Mineral Research, HSDM/HMS Harvard University, Boston, Massachusetts, USA
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Geert Carmeliet
Geert Carmeliet
Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium
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Martin Blomberg Jensen
Martin Blomberg Jensen
Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark
Division of Bone and Mineral Research, HSDM/HMS Harvard University, Boston, Massachusetts, USA
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Division of Bone and Mineral Research, HSDM/HMS Harvard University, Boston, Massachusetts, USA
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Introduction All the classical target organs of vitamin D – intestine, bone, and kidney – play a central role in the regulation of calcium and phosphate homeostasis ( Bouillon et al. 2008 , Lieben et al. 2011 ). However, in recent years
Jui-Cheng Hsieh
Jui-Cheng Hsieh
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Rudolf C Estess
Rudolf C Estess
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Ichiro Kaneko
Ichiro Kaneko
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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G Kerr Whitfield
G Kerr Whitfield
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Peter W Jurutka
Peter W Jurutka
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Mark R Haussler
Mark R Haussler
Department of Basic Medical Sciences, School of Mathematical and Natural Sciences, University of Arizona College of Medicine, 425 North 5th Street, Phoenix, Arizona 85004-2157, USA
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Introduction Molecular control of the mammalian hair cycle is incompletely characterized. Three gene products that are involved in this process are hairless (HR), the vitamin D receptor (VDR), and retinoid X receptor-α (RXRα). Loss
Rene F Chun
Rene F Chun
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
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John S Adams
John S Adams
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
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Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
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Martin Hewison
Martin Hewison
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
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Department of Orthopaedic Surgery, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
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Introduction At the end of 2007, Time magazine listed the ‘Benefits of Vitamin D’ as one of its top ten ‘medical breakthroughs’ of the year. The reason for this they stated has been the recent remarkable increase in studies documenting new actions
