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Rita E Roberts Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Jacqueline Cavalcante-Silva Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Rhonda D Kineman Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Timothy J Koh Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Introduction Wound healing requires the coordinated responses of diverse cell types and molecular pathways which participate in overlapping phases of coagulation, inflammation, proliferation and remodeling ( Singer & Clark 1999 , Eming et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0298
Volume/Issue:
Volume 252: Issue 1
Restricted access
Ana Tiganescu Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Melanie Hupe Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Yoshikazu Uchida Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Theodora Mauro Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Peter M Elias Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Walter M Holleran Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA

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Introduction Glucocorticoid (GC) excess, whether of endogenous (e.g., Cushing's syndrome, stress) or exogenous (e.g., topical or systemic therapy) origin, adversely affects multiple elements of wound healing, causing prolonged discomfort and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0420
Volume/Issue:
Volume 221: Issue 1
Free access
Akiko Komi-Kuramochi Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Mitsuko Kawano Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Yuko Oda Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Masahiro Asada Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Masashi Suzuki Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Junko Oki Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Toru Imamura Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Higashi, Tsukuba 305-8566, Ibaraki, Japan
University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305-8572, Japan

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Introduction Wound healing is a highly ordered process that involves cell proliferation and migration, matrix protein synthesis and deposition, and tissue remodeling. This process has been divided into an inflammatory phase, a

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06055
Volume/Issue:
Volume 186: Issue 2
Free access
BARBARA E. CLAYTON
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F. T. G. PRUNTY
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The formation of experimentally-produced granulation tissue can be inhibited by ACTH. It has been shown that pitressin tannate and chorionic gonadotrophin do not have this effect. No gonadotrophic activity could be detected in the sample of ACTH used.

Hypophysectomized mice became progressively and rapidly less responsive to ACTH.

The gonads were found to be essential for inhibition to occur.

Adrenalectomized mice at the beginning of the breeding season, adrenalectomized pregnant mice, and adrenalectomized mice pre-treated with chorionic gonadotrophin showed inhibition of healing by ACTH. Adrenalectomized mice pre-treated with follicle-stimulating hormone or pregnant mares' serum gonadotrophin were not inhibited.

Cortisone acetate causes inhibition in intact and gonadectomized mice. Neither testosterone, oestriol, nor oestradiol had any effect; but progesterone gave definite impairment under the conditions of the experiment.

It is suggested that the gonads are capable of responding to ACTH under the influence of luteinizing hormone.

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0070362
Volume/Issue:
Volume 7: Issue 4
Restricted access
Sara Merlo Department of Experimental and Clinical Pharmacology, DISCAFF, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
Department of Experimental and Clinical Pharmacology, DISCAFF, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy

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Giuseppina Frasca Department of Experimental and Clinical Pharmacology, DISCAFF, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy

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Pier Luigi Canonico Department of Experimental and Clinical Pharmacology, DISCAFF, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy

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Maria Angela Sortino Department of Experimental and Clinical Pharmacology, DISCAFF, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy

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pathological conditions ( Thornton 2005 ). Particularly relevant is the ability of the hormonal environment to affect wound healing that is a complex, multi-stage process involving inflammatory response, angiogenesis, and extracellular membrane deposition and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0442
Volume/Issue:
Volume 200: Issue 2
Free access
Georgia Papacleovoulou The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Hilary O D Critchley The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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Stephen G Hillier The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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J Ian Mason The Queen's Medical Research Institute, Centre for Reproductive Biology, Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh EH16 4TJ, UK

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. Collectively, all these responses further support the potential function of LOX in the early stages of wound healing processes and protection from malignant transformation/invasion. Actions of cytokines in COX-2 and LOX mRNA are summarised in Fig. 10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0081
Volume/Issue:
Volume 211: Issue 3
Free access
D. P. CUTHBERTSON
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G. B. SHAW
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F. G. YOUNG
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Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.0.0020475
Volume/Issue:
Volume 2: Issue 1
Restricted access
Yan Su Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Sujuan Guo Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Chunyan Liu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Na Li Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Shuang Zhang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yubin Ding Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xuemei Chen Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Junlin He Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Xueqing Liu Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Yingxiong Wang Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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Rufei Gao Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China
Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, China

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. Wound healing assay A migration assay was then performed in the presence or absence of PKM2 at 0 and 24 h. After transfected with Si-PKM2, wounds were made by perpendicular linear scratch using a pipette tip. The area of cell migration was measured

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0553
Volume/Issue:
Volume 245: Issue 3
Restricted access
Gordon J Allan SIPBS, University of Strathclyde, Glasgow G1 1XW, UK

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James Beattie SIPBS, University of Strathclyde, Glasgow G1 1XW, UK

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David J Flint SIPBS, University of Strathclyde, Glasgow G1 1XW, UK

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during processes such as wound healing or metastasis, where they are implicated in cellular adhesion and migration. Thus far, IGFBP5 has been shown to bind to osteopontin, thrombospondin-1 ( Nam et al . 2000 ) and tenascin-C ( Clemmons et al . 1995

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0269
Volume/Issue:
Volume 199: Issue 2
Free access
Zhenguang Zhang University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Agnes E Coutinho University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tak Yung Man University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tiina M J Kipari Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Patrick W F Hadoke University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Donald M Salter Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Jonathan R Seckl University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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(HSD1)-deficient Mice . Journal of Biological Chemistry 287 4188 – 4197 . ( doi:10.1074/jbc.M111.259325 ) 10.1074/jbc.M111.259325 Minutti CM Knipper JA Allen JE Zaiss DM 2016 Tissue-specific contribution of macrophages to wound

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0223
Volume/Issue:
Volume 234: Issue 3
Open access