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James A Oakes Department of Oncology & Metabolism, School of Medicine, University of Sheffield, Sheffield, UK
The Bateson Centre, Department of Biomedical Science, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Lise Barnard Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa

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Karl-Heinz Storbeck Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa

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Vincent T Cunliffe The Bateson Centre, Department of Biomedical Science, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Nils P Krone Department of Oncology & Metabolism, School of Medicine, University of Sheffield, Sheffield, UK
The Bateson Centre, Department of Biomedical Science, Firth Court, University of Sheffield, Western Bank, Sheffield, UK
Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Introduction The roles of androgens in zebrafish sex differentiation, development of male sexual characteristics, and maintenance and function of the adult testes are poorly understood. Laboratory strains of zebrafish lack sex chromosomes and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0160
Volume/Issue:
Volume 247: Issue 2
Free access
Gabriel Forn-Cuní Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Monica Varela Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Conrado M Fernández-Rodríguez Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Antonio Figueras Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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Beatriz Novoa Instituto de Investigaciones Marinas, Hospital Universitario Fundación Alcorcón, CSIC, Eduardo Cabello 6, 36208 Vigo, Spain

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, TLR2, TLR4, and TLR9 signal through the MyD88 pathway, activate NF-κβ, and result in the production of proinflammatory cytokines and chronic inflammation ( Miura et al . 2013 , Roh & Seki 2013 ). The zebrafish model is becoming a valuable tool for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0398
Volume/Issue:
Volume 224: Issue 2
Free access
Maria Tsachaki Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Arne Meyer Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
AstraZeneca AG, Zug, Switzerland

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Benjamin Weger Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics, Eggenstein-Leopoldshafen, Germany
Nestlé Institute of Health Sciences SA, EPFL Innovation Park, Lausanne, Switzerland

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Denise V Kratschmar Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Janina Tokarz Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany

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Jerzy Adamski Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany

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Heinz-Georg Belting Biozentrum, University of Basel, Basel, Switzerland

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Markus Affolter Biozentrum, University of Basel, Basel, Switzerland

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Thomas Dickmeis Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics, Eggenstein-Leopoldshafen, Germany

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Alex Odermatt Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Introduction The zebrafish ( Danio rerio ) has emerged as a powerful model organism to study disease mechanisms and for drug discovery and toxicity assessment ( Stern & Zon 2003 , Hill et al . 2005 , Zon & Peterson 2005 , Rubinstein 2006

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0495
Volume/Issue:
Volume 232: Issue 2
Free access
Nan Li Department of Oncology & Metabolism, Medicine, School of
The Bateson Centre, Firth Court, Western Bank, Sheffield, UK

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James A Oakes Department of Oncology & Metabolism, Medicine, School of
The Bateson Centre, Firth Court, Western Bank, Sheffield, UK

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Karl-Heinz Storbeck Department of Biochemistry, Stellenbosch University, Stellenbosch, Matieland, South Africa

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Vincent T Cunliffe The Bateson Centre, Firth Court, Western Bank, Sheffield, UK
Department of Biomedical Science, Firth Court, Western Bank, Sheffield, UK

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Nils P Krone Department of Oncology & Metabolism, Medicine, School of
The Bateson Centre, Firth Court, Western Bank, Sheffield, UK
Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Introduction Zebrafish has been established as vertebrate model to elucidate gene function in development and disease. Despite their evolutionary distances, zebrafish share extensive conservation with humans at both genomic and functional

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0384
Volume/Issue:
Volume 244: Issue 2
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Amrutha Bagivalu Lakshminarasimha Institute of Zoology, University of Cologne, Cologne, Germany

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Patrick Page-McCaw Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diana Möckel Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

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Felix Gremse Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany
Gremse-IT GmbH, Aachen, Germany

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Maximilian Michel Institute of Zoology, University of Cologne, Cologne, Germany

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( Chisada et al. 2014 ), Lepr in zebrafish ( Michel et al. 2016 , Fei et al. 2017 , Ahi et al. 2019 ), Lepa in zebrafish ( Michel et al. 2016 , Audira et al. 2018 ), and Lepb in zebrafish ( He et al. 2021 ). The reported results, however

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0037
Volume/Issue:
Volume 251: Issue 1
Restricted access
Yuxin Xie School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Lianhe Chu School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Yun Liu School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Kathy W Y Sham School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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Jianzhen Li School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
College of Life Sciences, Northwest Normal University, Lanzhou, China

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Christopher H K Cheng School of Biomedical Sciences, The Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

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, we have successfully established the lhb , fshb , lhr , fshr , lhb;fshb , lhr;fshr and fshb;lhr mutant zebrafish lines ( Liu et al . 2013 , 2014 , Chu et al . 2014 , 2015 ). Using these genetic means, we have analyzed the functions of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0079
Volume/Issue:
Volume 234: Issue 3
Free access
Wenxia He Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Xiangyan Dai Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Xiaowen Chen Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Jiangyan He Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Zhan Yin Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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limitations of the techniques employed in previous transcriptome analyses, global gene profiles of the animal pituitary typically lack comprehensiveness and accuracy. Zebrafish ( Danio rerio ) is one of the commonly used vertebrate model organisms in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0488
Volume/Issue:
Volume 221: Issue 3
Free access
Amrutha Bagivalu Lakshminarasimha Institute of Zoology, University of Cologne, Cologne, Germany

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Madhuri Puvvada Institute of Zoology, University of Cologne, Cologne, Germany

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Matthias Hammerschmidt Institute of Zoology, University of Cologne, Cologne, Germany

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Maximilian Michel Institute of Zoology, University of Cologne, Cologne, Germany

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), zebrafish ( Michel et al. 2016 , Fei et al. 2017 , Ahi et al. 2019 , Bagivalu Lakshminarasimha et al. 2021 , Kamstra et al. 2022 ), lepa in zebrafish ( Audira et al. 2018 , Bagivalu Lakshminarasimha et al. 2021 , Kamstra et al. 2022

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0026
Volume/Issue:
Volume 254: Issue 1
Restricted access
Cuili Wang State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China

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Dongteng Liu State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China

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Weiting Chen Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China

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Wei Ge Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, Macau, China

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Wanshu Hong State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China

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Yong Zhu State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Department of Biology, East Carolina University, Greenville, North Carolina, USA

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Shi X Chen State Key Laboratory of Marine Environmental Science, College of Ocean and Earth Sciences, Xiamen University, Xiamen, China
Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen, China
State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, China

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japonica ) demonstrated that DHP induces the entry of male germ cells into meiosis ( Miura et al . 2006 ). Our recent studies in zebrafish showed that DHP treatment increased proliferation and differentiation of early spermatogonial generation ( Chen et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0073
Volume/Issue:
Volume 230: Issue 1
Free access
Rubén Marín-Juez
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Susanne Jong-Raadsen
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Shuxin Yang ZF‐Screens BV, Institute of Biology, J.H. Oortweg 19, 2333 CH Leiden, The Netherlands

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Herman P Spaink ZF‐Screens BV, Institute of Biology, J.H. Oortweg 19, 2333 CH Leiden, The Netherlands

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conflicting results compared with the human situation, mainly due to the heterogeneity of the metabolic states where insulin resistance is observed ( Harano et al . 2002 , Kahn 2003 , Steinberger & Daniels 2003 ). The zebrafish ( Danio rerio ) is emerging

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0178
Volume/Issue:
Volume 222: Issue 2
Free access