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Noriko Tagawa, Ryosuke Yuda, Sayaka Kubota, Midori Wakabayashi, Yuko Yamaguchi, Daisuke Kiyonaga, Natsuko Mori, Erika Minamitani, Hiroaki Masuzaki and Yoshiharu Kobayashi

activation is 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which generates active glucocorticoids (cortisol in humans and corticosterone in rodents) from inactive metabolites (cortisone in humans and 11-dehydrocorticosterone in rodents; Stewart

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Noriko Tagawa, Sayaka Kubota, Ikuo Kato and Yoshiharu Kobayashi

tissue function, development, and distribution. Intracellular glucocorticoid levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and 11β-HSD2. 11β-HSD1, which is abundantly expressed in the adipose tissue and in the liver, acts as

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I J Bujalska, L L Gathercole, J W Tomlinson, C Darimont, J Ermolieff, A N Fanjul, P A Rejto and P M Stewart

, specifically in omental depots, can be generated from inactive circulating cortisone (in humans) or 11-dehydrocorticosterone (in rodents) through the oxo-reductase activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Bujalska et al . 1997 b

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M Lauterburg, G Escher, B Dick, D Ackermann and F J Frey

Y Liang G Li X 2010 11β-Hydroxysteroid dehydrogenase type 1 inhibitors as promising therapeutic drugs for diabetes: status and development . Current Medicinal Chemistry 17 412 – 422 . doi:10.2174/092986710790226147 . Hostetter TH

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C Chandras, T E Harris, A López Bernal, D R E Abayasekara and A E Michael

dehydrogenase determines the reaction direction of 11β-hydroxysteroid dehydrogenases type 1 as an oxoreductase. FEBS Letters 571 129 –133. Banhegyi G , Benedetti A, Fulceri R & Senesi S 2004 Cooperativity between 11β-hydroxysteroid

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Zhen Yang, Chunming Guo, Ping Zhu, Wenjiao Li, Leslie Myatt and Kang Sun

, Ebert A, Zimmermann B, Kotelevtsev YV, Mullins JJ & Seckl JR 2002 Foetal lung maturation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice. Hormone Metabolic Research 34 545 –549. Karalis K , Goodwin G & Majzoub

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Noriko Tagawa, Sayaka Kubota, Ikuo Kato and Yoshiharu Kobayashi

: Resveratrol inhibited 11β-HSD1 in rat mesenteric fat pads Resveratrol inhibited 11β-HSD1 reductase activity (conversion of 11-dehydrocorticosterone to corticosterone) significantly by 47.7% (0.85±0.04 nmol/h per mg protein) compared with the control (1

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Lianne Abrahams, Nina M Semjonous, Phil Guest, Agnieszka Zielinska, Beverly Hughes, Gareth G Lavery and Paul M Stewart

Introduction 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a 34 kDa enzyme anchored in the endoplasmic reticulum (ER) membrane, with its catalytic domain projecting into the ER lumen ( Odermatt et al . 1999 ). In vitro , 11β-HSD1 is

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Ana Tiganescu, Melanie Hupe, Yoshikazu Uchida, Theodora Mauro, Peter M Elias and Walter M Holleran

fully understood. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bidirectional enzyme that, in intact cells, generates corticosterone from 11-dehydrocorticosterone (11-DHC) in rodents (and cortisol from cortisone in humans), regulating local GC

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Zhenguang Zhang, Agnes E Coutinho, Tak Yung Man, Tiina M J Kipari, Patrick W F Hadoke, Donald M Salter, Jonathan R Seckl and Karen E Chapman

1998 ). Macrophages express 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a glucocorticoid metabolising enzyme that, in intact cells, converts the intrinsically inert cortisone and 11-dehydrocorticosterone into the active glucocorticoids