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Rebecca L Hull, Joshua R Willard, Matthias D Struck, Breanne M Barrow, Gurkirat S Brar, Sofianos Andrikopoulos, and Sakeneh Zraika

, Winzell & Ahren 2004 ). A number of C57BL/6 substrains now exist. The strain was generated from the C57BL mouse colony originally established by C C Little in 1921 and has been maintained at The Jackson Laboratory since 1948. These Jackson mice were

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E Meimaridou, M Goldsworthy, V Chortis, E Fragouli, P A Foster, W Arlt, R Cox, and L A Metherell

( Fig. 4C ). Transcriptome profiling by RNA-seq in adrenals from the C57BL/6 mouse substrains To investigate the cause of the reduced steroid production upon Nnt deletion, RNA was extracted from Nnt +/+ , Nnt −/− , and Nnt BAC mouse

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Sofianos Andrikopoulos, Christine M Massa, Kathryn Aston-Mourney, Alexandra Funkat, Barbara C Fam, Rebecca L Hull, Steven E Kahn, and Joseph Proietto

insulin in response to arginine. These results may suggest that the 129 substrains may not respond to glucose as an insulin secretagogue to the same extent as other mouse strains (C57BL/6, DBA/2), but do respond to other stimuli such as arginine

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Greg M Kowalski, Michael J Kraakman, Shaun A Mason, Andrew J Murphy, and Clinton R Bruce

highlighting that metabolic differences can exist between substrains of C57Bl/6J mice ( Hull et al . 2017 ). In conclusion, we have identified the paradoxical observation that long-term HFSD feeding results in the resolution of diet-induced glucose

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David M Cartwright, Lucy A Oakey, Rachel S Fletcher, Craig L Doig, Silke Heising, Dean P Larner, Daniela Nasteska, Caitlin E Berry, Sam R Heaselgrave, Christian Ludwig, David J Hodson, Gareth G Lavery, and Antje Garten

-018-03421-7 ) Mekada K Abe K Murakami A Nakamura S Nakata H Moriwaki K Obata Y Yoshiki A 2009 Genetic differences among C57BL/6 substrains . Experimental Animals 58 141 – 149 . ( https://doi.org/10.1538/expanim.58.141 ) Mills KF Yoshida S

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R Prasad, J C Kowalczyk, E Meimaridou, H L Storr, and L A Metherell

affect steroidogenesis. NNT is widely expressed with high levels apparent in the adrenal gland in both human and mouse tissues ( Meimaridou et al . 2012 ). A substrain of C57BL6/J mice carries a spontaneous Nnt mutation leading to a 5-exon deletion

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Benjamin J Lamont and Sofianos Andrikopoulos

, particularly once treatment has ceased. Normal mice The majority of studies that have described the effects of GLP1R agonists in normal mice have been carried out using the C57BL/6 laboratory strain. This inbred mouse strain is known to expand β-cell mass in

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Matthew J VandeKopple, Jinghai Wu, Lisa A Baer, Naresh C Bal, Santosh K Maurya, Anuradha Kalyanasundaram, Muthu Periasamy, Kristin I Stanford, Amato J Giaccia, Nicholas C Denko, and Ioanna Papandreou

obtained by standard molecular cloning methods and linearized before electroporation into C57BL/6-Tac ES cells. The targeted ES cells were injected into FVB blastocysts and chimeras were mated to WT C57BL/6-Tac females. We received mice at N3, F5 and back

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James E Bowe, Zara J Franklin, Astrid C Hauge-Evans, Aileen J King, Shanta J Persaud, and Peter M Jones

.2008 ) Mekada K Abe K Murakami A Nakamura S Nakata H Moriwaki K Obata Y Yoshiki A 2009 Genetic differences among C57BL/6 substrains . Experimental Animals 58 141 – 149 . ( doi:10.1538/expanim.58.141 ) Muniyappa R Lee S Chen H Quon

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Malin Fex, Lisa M Nicholas, Neelanjan Vishnu, Anya Medina, Vladimir V Sharoyko, David G Nicholls, Peter Spégel, and Hindrik Mulder

species (ROS), which could impair their function ( Jonas et al . 2009 ). Glutathione reductase requires NADPH to reduce glutathione, a component of the detoxifying mechanism. Recent studies in this substrain of C57BL/6J show that NNT is required for the