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Laura E Pascal, Khalid Z Masoodi, June Liu, Xiaonan Qiu, Qiong Song, Yujuan Wang, Yachen Zang, Tiejun Yang, Yao Wang, Lora H Rigatti, Uma Chandran, Leandro M Colli, Ricardo Z N Vencio, Yi Lu, Jian Zhang and Zhou Wang

Introduction ELL2 (elongation factor, RNA polymerase II, 2; previously eleven-nineteen lysine-rich leukemia 2) is an RNA Pol II elongation factor with functional properties similar to ELL and ELL3 ( Shilatifard et al. 1997 , Miller et al

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Peter J Fuller, Jun Yang and Morag J Young

( Fuse et al. 2000 ) PGC-1α AF-2 Recruits histone acetyltransferase complex; facilitates binding of NR to transcription initiation complex ( Hultman et al. 2005 , Knutti et al. 2000 ) ELL AF-1b RNA polymerase II elongation

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Shuisheng Li, Yong Zhang, Yun Liu, Xigui Huang, Weiren Huang, Danqi Lu, Pei Zhu, Yu Shi, Christopher H K Cheng, Xiaochun Liu and Haoran Lin

kisspeptin/GPR54 system in the neuroendocrine regulation of reproduction remains to be established. Recently, two kiss1 genes, namely kiss1 and kiss2 , were identified in zebrafish and medaka ( Kitahashi et al . 2008 ) as well as in sea bass ( Felip et

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Marcos C Carreira, Jesus P Camiña, Esther Díaz-Rodríguez, Rodrigo Alvear-Perez, Catherine Llorens-Cortes and Felipe F Casanueva

-adenosine, and the ECL detection kit was from Amersham Pharmacia Biotech. Polyalylamine hydrochloride was provided by Sigma. Glass slides were provided by Nalge Nunc (Nalge Europe Ltd, Hereford, UK). Fura-2 pentaacetoxymethylester (fura-2/AM) was obtained from

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Yong Zhang, Yun Liu, Xigui Huang, Xiaochun Liu, Baowei Jiao, Zining Meng, Pei Zhu, Shuisheng Li, Haoran Lin and Christopher H K Cheng

al . 2007 ). GPR39 was encoded by a single-copy gene in the human genome mapped to the chromosome location 2q21–q22 ( McKee et al . 1997 ). Northern blot and reverse transcription PCR (RT-PCR) analyses indicated that GPR39 is predominantly expressed

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Christian Hölscher

Introduction The main hallmark of type 2 diabetes mellitus (T2DM) is insulin desensitisation. The discovery that the incretin hormone glucagon-like peptide 1 (GLP-1) facilitates insulin release during episodes of hyperglycaemia and has several

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Anthony J Weinhaus, Laurence E Stout, Nicholas V Bhagroo, T Clark Brelje and Robert L Sorenson

to the PRL receptor (PRL-r) and activating the JAK2/STAT5 pathway ( Sorenson & Stout 1995 , Galsgaard et al. 1999 , Brelje et al. 2002 , 2004 ). Phosphorylated STAT5 proteins dimerize, translocate to the nucleus, and bind to palindromic γ

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Rebecca M Reynolds and Adrienne Gordon

Background Within the current global crisis of obesity (BMI ≥30 kg/m 2 ), women of reproductive age represent a group with the steepest rises in obesity rates over recent decades ( NCD Risk Factor Collaboration 2016 ). In the United Kingdom

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Bethania Mongi-Bragato, Ezequiel Grondona, Liliana del Valle Sosa, Natacha Zlocowski, Ana Clara Venier, Alicia Inés Torres, Alexandra Latini, Rodrigo Bainy Leal, Silvina Gutiérrez and Ana Lucía De Paul

around 0.2% or less of all clinical cases ( Scheithauer et al . 2006 ). Relevant evidence associated premature cell senescence mechanisms with the features of pituitary adenomas ( Chesnokova et al . 2007 , 2008 ), a process conceived as a tumour

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Alessandro Pocai

Introduction As the prevalence of type 2 diabetes increases, there is a medical need for additional antihyperglycemic agents that offer improved efficacy in glycemic control and tolerability. Obesity is an important risk factor for a number of