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Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China
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Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China
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Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China
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). However, effects of SRT1720 on DN remain unknown. Chronic hypoxia has been implicated in the development and progression of DN ( Singh et al. 2008 ). Hypoxia inducible factor 1 alpha (HIF1A) is a key transcriptional regulator of cellular adaptation to
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Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
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Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
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oxygen and nutrients to the tumour cells and to remove intratumoural waste products ( Turner et al . 2000 , Carmeliet 2003 ). Tumour neovascularisation is induced by intratumoural hypoxia, which leads to an increase in hypoxia inducible factor 1α (HIF1A
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response to oxygen deficiency in this organ. However, the precise mechanism regulating GLUT1 expression during placentation has not been fully clarified. Heterodimeric hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that mediates
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against human HIF-1α (BD Transduction Laboratories, Stockholm, Sweden), rabbit polyclonal antibody against VEGF-A (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA), rabbit polyclonal antibody against carbonic anhydrase 9 (CA-9, Novus Biologicals
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. In human dermal microvascular endothelial cells, a high-glucose concentration impaired hypoxia-independent protection of HIF-1α against proteasomal degradation ( Catrina et al . 2004 ). In rat kidney mesangial cells, a high-glucose concentration
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)-1α (listed as HIF1A in the Hugo Database) activation, which results in endothelial cell proliferation and tube formation ( Yamakawa et al . 2003 ). VEGF has been implicated as playing an important role in placental angiogenesis ( Ferrara et al
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to muscle contraction, which reduces the intracellular oxygen tension, and that involves increased binding of the hypoxia-inducible factor 1A ( Hif1a ) into the Slc2a4 promoter region ( Lima et al . 2009 ). Additionally, some studies further
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The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
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The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
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(HIF) is a transcription factor that binds to the hypoxia responsive elements (HRE) in the promoter region of more than 100 genes including IGFBP1 and mediates the adaptive response to hypoxia ( Semenza 2011 ). HIF is a heterodimeric factor composed of
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LH-induced processes, e.g. steroidogenesis: Mvk , Lss , Cyp11a1 , Hsd3b1 , Cyp19a1 , Nr4a1 , and Timp1 ; final differentiation of granulosa cells: Lhcgr , Oxtr , Pgr , Egfr , Hif1a , and Vegfa ; and cytokine expression: Cxcl12 , Cxcr4
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
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Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
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show that TRs deletion causes a milder hematopoietic phenotype than hypothyroidism. Contrary to that observed in hypothyroid animals, TRα1/TRβ KO animals do not display overt anemia or decreased Gata 1 or Hif 1 gene expression and a reduction of the