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Weixia Han Department of Pathology, Hebei Medical University, Shijiazhuang, China
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China

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Chen Wang Department of Pathology, Second Hospital, Shanxi Medical University, Taiyuan, China

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Zhifen Yang Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Lin Mu Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Ming Wu Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Nan Chen Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Chunyang Du Department of Pathology, Hebei Medical University, Shijiazhuang, China

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Huijun Duan Department of Pathology, Hebei Medical University, Shijiazhuang, China
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China

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Yonghong Shi Department of Pathology, Hebei Medical University, Shijiazhuang, China
Hebei Key Laboratory of Kidney Diseases, Shijiazhuang, China

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). However, effects of SRT1720 on DN remain unknown. Chronic hypoxia has been implicated in the development and progression of DN ( Singh et al. 2008 ). Hypoxia inducible factor 1 alpha (HIF1A) is a key transcriptional regulator of cellular adaptation to

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B Shan
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C Schaaf
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A Schmidt
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K Lucia
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M Buchfelder Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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M Losa Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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D Kuhlen Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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J Kreutzer Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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M J Perone Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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E Arzt Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany
Neuroendocrinology Group, Department of Neurosurgery, Department of Neurosurgery, Department of Neurosurgery, Laboratorio de Fisiología y Biología Molecular, IBioBA–CONICET, Max Planck Institute of Psychiatry, Kraepelinstraße 10, D-80804 Munich, Germany

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G K Stalla
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U Renner
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oxygen and nutrients to the tumour cells and to remove intratumoural waste products ( Turner et al . 2000 , Carmeliet 2003 ). Tumour neovascularisation is induced by intratumoural hypoxia, which leads to an increase in hypoxia inducible factor 1α (HIF1A

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Masami Hayashi
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Masahiro Sakata
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Takashi Takeda
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Toshiya Yamamoto
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Yoko Okamoto
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Kenjiro Sawada
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Akiko Kimura
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Ryoko Minekawa
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Masahiro Tahara
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Keiichi Tasaka
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Yuji Murata
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response to oxygen deficiency in this organ. However, the precise mechanism regulating GLUT1 expression during placentation has not been fully clarified. Heterodimeric hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that mediates

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Stina Häggström Rudolfsson Surgical and Perioperative Sciences, Medical Biosciences, Urology and Andrology and

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Anders Bergh Surgical and Perioperative Sciences, Medical Biosciences, Urology and Andrology and

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against human HIF-1α (BD Transduction Laboratories, Stockholm, Sweden), rabbit polyclonal antibody against VEGF-A (Santa Cruz Biotechnology Inc., Santa Cruz, CA, USA), rabbit polyclonal antibody against carbonic anhydrase 9 (CA-9, Novus Biologicals

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Toshiaki Ishizuka Department of Pharmacology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

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Takashi Hinata Department of Pharmacology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

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Yasuhiro Watanabe Department of Pharmacology, National Defense Medical College, 3-2, Namiki, Tokorozawa, Saitama 359-8513, Japan

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. In human dermal microvascular endothelial cells, a high-glucose concentration impaired hypoxia-independent protection of HIF-1α against proteasomal degradation ( Catrina et al . 2004 ). In rat kidney mesangial cells, a high-glucose concentration

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Daisuke Fujita Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Akiko Tanabe Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Tatsuharu Sekijima Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Hekiko Soen Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Keijirou Narahara Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Yoshiki Yamashita Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Yoshito Terai Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Hideki Kamegai Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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Masahide Ohmichi Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-City, Osaka 569-8686, Japan

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)-1α (listed as HIF1A in the Hugo Database) activation, which results in endothelial cell proliferation and tube formation ( Yamakawa et al . 2003 ). VEGF has been implicated as playing an important role in placental angiogenesis ( Ferrara et al

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Liza Margareth Medeiros de Carvalho Sousa Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Renata dos Santos Silva Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Vanessa Uemura da Fonseca Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Rafael Magdanelo Leandro Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Thiago Senna Di Vincenzo Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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Ana Bárbara Alves-Wagner Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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Ubiratan Fabres Machado Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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Paula de Carvalho Papa Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil

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to muscle contraction, which reduces the intracellular oxygen tension, and that involves increased binding of the hypoxia-inducible factor 1A ( Hif1a ) into the Slc2a4 promoter region ( Lima et al . 2009 ). Additionally, some studies further

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Elisabete A Forsberg The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Ileana R Botusan The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Jing Wang The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Verena Peters The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Ishrath Ansurudeen The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Kerstin Brismar The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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Sergiu Bogdan Catrina The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden
The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Endocrinology, Center for Pediatric and Adolescent Medicine, Karolinska Institutet, Stockholm, Sweden

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(HIF) is a transcription factor that binds to the hypoxia responsive elements (HRE) in the promoter region of more than 100 genes including IGFBP1 and mediates the adaptive response to hypoxia ( Semenza 2011 ). HIF is a heterodimeric factor composed of

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Ingrid Segers Follicle Biology Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Jette, Belgium

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Tom Adriaenssens Follicle Biology Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Jette, Belgium

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Sandra Wathlet Follicle Biology Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Jette, Belgium

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Johan Smitz Follicle Biology Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Jette, Belgium

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LH-induced processes, e.g. steroidogenesis: Mvk , Lss , Cyp11a1 , Hsd3b1 , Cyp19a1 , Nr4a1 , and Timp1 ; final differentiation of granulosa cells: Lhcgr , Oxtr , Pgr , Egfr , Hif1a , and Vegfa ; and cytokine expression: Cxcl12 , Cxcr4

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Ángela Sánchez Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

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Constanza Contreras-Jurado Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain

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Diego Rodríguez Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

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Javier Regadera Department of Anatomy, Histology and Neuroscience, Universidad Autónoma de Madrid, Madrid, Spain

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Susana Alemany Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

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Ana Aranda Instituto de Investigaciones Biomédicas ‘Alberto Sols’, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain

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show that TRs deletion causes a milder hematopoietic phenotype than hypothyroidism. Contrary to that observed in hypothyroid animals, TRα1/TRβ KO animals do not display overt anemia or decreased Gata 1 or Hif 1 gene expression and a reduction of the

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