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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

Introduction Obesity is the single most important risk factor for the development of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease in the western hemisphere ( Lazo & Clark 2008 , Bellentani et al . 2010

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Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Marcella Ramos Sant’Ana, Thaís Dantis Pereira de Campos, Rodrigo Stellzer Gaspar, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Rania A Mekary, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli, and Leandro Pereira de Moura

Introduction Nonalcoholic fatty liver disease (NAFLD) is a pre-condition for most common liver diseases, and it can be developed from hepatic steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, to hepatocellular carcinoma (HCC) ( Tilg

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Lei Yu, Haoran Wang, Xiaoxue Han, Honghui Liu, Dalong Zhu, Wenhuan Feng, Jinhui Wu, and Yan Bi

Introduction Non-alcoholic fatty liver disease (NAFLD), a major epidemic chronic liver disease worldwide, is often accompanied by systemic metabolic disorders, such as obesity, type 2 diabetes and cardiovascular diseases ( Byrne & Targher 2015

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Guangcui Xu, Tingting Yan, Qiang Peng, Haibin Li, Weidong Wu, Xianwen Yi, and Yingzheng Zhao

Introduction In association with the obesity pandemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progressive form, nonalcoholic steatohepatitis ( Sanyal et al . 2010 ), is rising in the whole world and is estimated to

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Gabriel Forn-Cuní, Monica Varela, Conrado M Fernández-Rodríguez, Antonio Figueras, and Beatriz Novoa

diseases are part of a condition termed metabolic syndrome. The hepatic component of metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This term comprises a wide range of progressive liver injuries including bland steatosis, variable degrees

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Ya Liu, Xiaoqing Zhou, Ye Xiao, Changjun Li, Yan Huang, Qi Guo, Tian Su, Lei Fu, and Liping Luo

Introduction Nonalcoholic fatty liver disease (NAFLD), characterized mainly by hepatic steatosis, is the most common liver disease worldwide ( Birkenfeld & Shulman 2014 , Meex & Watt 2017 ). It is reported that NAFLD is closely associated

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Christopher M Mulligan and Jacob E Friedman

properly. Depending on the health of the mother, maternal microbe communities may already be imbalanced when passed on to the infant. In children, metabolic diseases, including obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD), along

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João Paulo G Camporez, Mohamed Asrih, Dongyan Zhang, Mario Kahn, Varman T Samuel, Michael J Jurczak, and François R Jornayvaz

(NHANES), it is estimated that more than 34% of adults are obese and 68% are overweight or obese ( Flegal et al . 2010 ). In parallel with obesity, nonalcoholic fatty liver disease (NAFLD), which is now the most prevalent chronic liver disease in the USA

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Qiong Lv, Rufei Gao, Chuan Peng, Juan Yi, Lulu Liu, Shumin Yang, Danting Li, Jinbo Hu, Ting Luo, Mei Mei, Ying Song, Chaodong Wu, Xiaoqiu Xiao, and Qifu Li

Introduction Excess hepatic deposition of lipids, especially triglyceride (TG), is one of the important features of nonalcoholic fatty liver disease (NAFLD). Over-nutrition, metabolic diseases and genetic factors were widely considered to

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Nikolaos Nikolaou, Anastasia Arvaniti, Nathan Appanna, Anna Sharp, Beverly A Hughes, Dena Digweed, Martin J Whitaker, Richard Ross, Wiebke Arlt, Trevor M Penning, Karen Morris, Sherly George, Brian G Keevil, Leanne Hodson, Laura L Gathercole, and Jeremy W Tomlinson

decrease in expression with advancing severity of non-alcoholic fatty liver disease (NAFLD) ( Valanejad et al. 2018 , Nikolaou et al. 2019 b ). In this context, AKR1D1 knockdown increased the expression of key enzymes involved in lipogenesis as