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Hiroki Saito, Tomoya Nakamachi, Kazuhiko Inoue, Ryuji Ikeda, Kazuo Kitamura, Naoto Minamino, Seiji Shioda and Atsuro Miyata

Introduction Originally isolated from porcine spinal cord, neuromedin B (NMB) is a member of the bombesin-like peptide family, which also includes gastrin-releasing peptide (GRP) in mammals ( Minamino et al . 1983 , Ohki-Hamazaki 2000 ). NMB has

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EE Ladenheim, LL Hampton, AC Whitney, WO White, JF Battey and TH Moran

Bombesin (BN) interacts with two mammalian receptor subtypes termed gastrin-releasing peptide (GRP)-preferring (GRP-R) and neuromedin B (NMB)-preferring (NMB-R) that may mediate the satiety action of BN. We examined the feeding behavior of mice that were deficient in the GRP-R (GRP-R KO) to assess the overall contribution of this receptor subtype in the feeding actions of BN-related peptides. GRP-R KO mice failed to suppress glucose intake in response to systemically administered BN and GRP(18-27), whereas both peptides elicited a potent reduction of intake in wild-type (WT) mice. Neither GRP-R KO nor WT mice suppressed glucose intake following NMB administration. Unlike the impaired responses to BN-like peptides, the feeding inhibitory action of cholecystokinin was enhanced in GRP-R KO mice. Consistent with behavioral results, GRP-R KO mice also exhibited a reduction in c-Fos immunoreactivity in the nucleus of the solitary tract (NTS) and paraventricular nucleus (PVN) following peripheral administration of BN. An evaluation of meal patterns showed that GRP-R KO mice ate significantly more at each meal than WT mice, although total 24 h food consumption was equivalent. A long-term analysis of body weight revealed a significant elevation in GRP-R KO mice compared with WT littermates beginning at 45 weeks of age. These data suggest that the GRP-R mediates the feeding effects of BN-like peptides and participates in the termination of meals in mice.

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Keiko Nakahara, Tetsuro Katayama, Keisuke Maruyama, Takanori Ida, Kenji Mori, Mikiya Miyazato, Kenji Kangawa and Noboru Murakami

Y Ida T Miyazato M Kangawa K Murakami N 2004b Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice . Biochemical and Biophysical Research Communications 323 615 – 620 doi:10.1016/j

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T J Kowalski, B D Spar, L Markowitz, M Maguire, A Golovko, S Yang, C Farley, J A Cook, G Tetzloff, L Hoos, R A Del Vecchio, T M Kazdoba, M F McCool, J J Hwa, L A Hyde, H Davis, G Vassileva, J A Hedrick and E L Gustafson

Introduction Neuromedin U (NmU) is a peptide that was first isolated from porcine spinal cord ( Minamino et al. 1985 a , b ). Two active peptides were identified in this work: an amidated 25-amino-acid peptide (NmU-25) that is

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Ruben Nogueiras, Sulay Tovar, Sharon E Mitchell, Perry Barrett, D Vernon Rayner, Carlos Dieguez and Lynda M Williams

Introduction Neuromedin U (NMU) was first isolated from porcine spinal cord and named for its potent contractile activity on the uterus. It is a highly conserved molecule existing in two molecular forms: an octapeptide (NMU-8

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Christoph Melcher, Ruediger Bader and Michael J Pankratz

dining table. As amino acids are the building blocks for driving cellular and organismal growth, it is not surprising that they should have such profound effects on taste and feeding response in the CNS. Neuromedins and hugin We

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M A L Costa da Veiga, K de Jesus Oliveira, F H Curty and C C Pazos de Moura

euthyroid ones. This enhanced action of an inhibitory local factor may be contributing to the suppression of TSH release present in hyperthyroidism. Other important local TSH-releasing inhibitors, such as the bombesin-like peptide, neuromedin B has its

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Berit Svendsen, Ramona Pais, Maja S Engelstoft, Nikolay B Milev, Paul Richards, Charlotte B Christiansen, Kristoffer L Egerod, Signe M Jensen, Abdella M Habib, Fiona M Gribble, Thue W Schwartz, Frank Reimann and Jens J Holst

perfused mouse proximal small intestine. The intestine was stimulated with vascular infusion of (A) and (B) bombesin (10 nM) and forskolin/IBMX (10 μM); and (C) and (D) neuromedin C (10 nM) and KCl (70 mM). (B) and (D) Total hormone outputs from 5 min

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A Boelen, J Kwakkel, X G Vos, W M Wiersinga and E Fliers

others in the thyrotropic cells play an important role in TSHβ gene expression ( Shupnik 2000 ), and it is possible that a period of fasting affects these proteins also independently of leptin. A recent study has shown that neuromedin B (NB), a bombesin

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Flavia Fonseca Bloise, Felipe Leite de Oliveira, Alberto Félix Nobrega, Rita Vasconcellos, Aline Cordeiro, Luciana Souza de Paiva, Dennis D Taub, Radovan Borojevic, Carmen Cabanelas Pazos-Moura and Valéria de Mello-Coelho

-Hamazaki H Wada K Wada E Pazos-Moura CC 2006 Disruption of neuromedin B receptor gene results in dysregulation of the pituitary–thyroid axis . Journal of Molecular Endocrinology 36 73 – 80 . ( doi:10.1677/jme.1.01892 ) Ouchida R Mori H Hase