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Qinglei Yin Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Liyun Shen Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Yicheng Qi Division of Endocrinology and Metabolism, Department of Internal Medicine, RenJi Hospital, Shanghai Jiao-Tong University School of Medicine, Pudong, Shanghai, China

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Dalong Song Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Science, Guangzhou, China

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Lei Ye Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Ying Peng Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Yanqiu Wang Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Zhou Jin Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Guang Ning Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Weiqing Wang Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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Dongping Lin Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Affiliated Shanghai Jiao-Tong University School of Medicine, Shanghai, China

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Shu Wang Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of EndocrineRuijin Hospital, Shanghai Jiao-Tong University School of Medicine, China

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mechanism remains unclear. SIRT1 is a class III histone/protein deacetylase (HDAC) and a member of the silent information regulator (Sir2) family. The mammalian sirtuin SIRT1 has received much attention for the roles it plays in regulating metabolism and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0501
Volume/Issue:
Volume 246: Issue 2
Open access
Sun-O Ka Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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Mi-Young Song Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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Eun Ju Bae Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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Byung-Hyun Park Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

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on a HFD ( Arkan et al . 2005 , Solinas et al . 2007 ). SIRT1, an NAD + -dependent histone deacetylase, is an important regulator of the metabolic response to caloric restriction ( Chalkiadaki & Guarente 2012 ). Additional evidence indicates that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0527
Volume/Issue:
Volume 224: Issue 2
Free access
Robert L Moore Cancer Center, Departments of Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, Room K-701, Boston, Massachusetts 02118-2307, USA

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Douglas V Faller Cancer Center, Departments of Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, Room K-701, Boston, Massachusetts 02118-2307, USA
Cancer Center, Departments of Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, Room K-701, Boston, Massachusetts 02118-2307, USA

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Introduction The sirtuins are a family of enzymes with increasingly recognized relevance to cancer ( Moore 2011 ), but the full extent of their involvement in breast cancer genesis and evolution remains to be elucidated. Sirtuin 1 (SIRT1) is a NAD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0102
Volume/Issue:
Volume 216: Issue 3
Free access
Hao Wu Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
The ‘973’ National Basic Research Program of China, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Junduo Wu Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Shengzhu Zhou Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Wenlin Huang School of Science and Technology, Georgia Gwinnett College, Lawrenceville, Georgia, USA

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Ying Li Department of Dermatology, Affiliated Hospital of Beihua University, Jilin, Jilin, People’s Republic of China

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Huan Zhang Operating Theatre, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Junnan Wang Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Ye Jia Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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) ( Giovannini et al . 2016 , Meek & Morton 2016 ), it is of great importance and urgency to develop more effective approaches to prevent the pathogenesis of diabetic vasculopathy. Previous reports highlighted the beneficial effect of sirtuin 1 (SIRT1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0672
Volume/Issue:
Volume 237: Issue 1
Free access
Paul W Caton Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Nanda K Nayuni Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Noorafza Q Khan Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Elizabeth G Wood Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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Roger Corder Department of Translational Medicine and Therapeutics, Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK

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between excess fructose consumption and impaired glucose and lipid homeostasis, the mechanisms responsible have yet to be elucidated. Recent studies have demonstrated the essential role of SIRT1, an NAD + -dependent protein deacetylase, in the regulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-10-0190
Volume/Issue:
Volume 208: Issue 3
Free access
Mathieu Lafontaine-Lacasse Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Y3106 Pavillon Marguerite-d'Youville, 2725 Chemin Ste-Foy, Québec, Québec, Canada G1V 4G5

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Geneviève Doré Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Y3106 Pavillon Marguerite-d'Youville, 2725 Chemin Ste-Foy, Québec, Québec, Canada G1V 4G5

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Frédéric Picard Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Y3106 Pavillon Marguerite-d'Youville, 2725 Chemin Ste-Foy, Québec, Québec, Canada G1V 4G5

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( Vanderford et al . 2007 ). SIRT1 is a deacetylase enzyme mostly located in the nucleus but also found in the cytoplasm under certain conditions ( Tanno et al . 2007 ). Its NAD-dependent activity suggests that this protein may sense the metabolic state of

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0243
Volume/Issue:
Volume 208: Issue 1
Free access
Paul W Caton Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK

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Nanda K Nayuni Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK

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Julius Kieswich Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK

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Noorafza Q Khan Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK

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Muhammed M Yaqoob Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK

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Roger Corder Bart's and the London School of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University, London EC1M 6BQ, UK

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et al . 2003 , Rhee et al . 2003 ). SIRT1, an NAD + -dependent protein deacetylase, inhibits gluconeogenesis through disruption of TORC2 signalling. During fasting TORC2 is acetylated, which protects it against COP1-mediated ubiquitination and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0345
Volume/Issue:
Volume 205: Issue 1
Free access
Carla Tatone Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Giovanna Di Emidio Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Martina Placidi Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Giulia Rossi Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Stefania Ruggieri Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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Chiara Taccaliti Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy

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Angela D’Alfonso Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Fernanda Amicarelli Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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Maurizio Guido Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy

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SIRT1, one of the seven members of the mammalian sirtuin family, has recently emerged. SIRT1 is known to regulate oocyte and somatic cell physiology during almost all stages of folliculogenesis ( Tatone et al. 2015 , 2018 ). Recently, our research

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0143
Volume/Issue:
Volume 251: Issue 2
Free access
Martha Lappas Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Department of Medicine, Mercy Hospital for Women, University of Melbourne, Level 4/163 Studley Road, Heidelberg 3084, Victoria, Australia
Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Department of Medicine, Mercy Hospital for Women, University of Melbourne, Level 4/163 Studley Road, Heidelberg 3084, Victoria, Australia

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Sofianos Andrikopoulos Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Department of Medicine, Mercy Hospital for Women, University of Melbourne, Level 4/163 Studley Road, Heidelberg 3084, Victoria, Australia

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Michael Permezel Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Department of Medicine, Mercy Hospital for Women, University of Melbourne, Level 4/163 Studley Road, Heidelberg 3084, Victoria, Australia
Department of Obstetrics and Gynaecology, Mercy Perinatal Research Centre, Department of Medicine, Mercy Hospital for Women, University of Melbourne, Level 4/163 Studley Road, Heidelberg 3084, Victoria, Australia

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), IRS1 (QT00074144), PI3K p85α (QT01005984), GLUT1 (QT00068957), GLUT3 (QT00047124), GLUT4 (QT00097902) and SIRT1 (QT00051261) were purchased from Qiagen. The syncytin primer has previously been described ( Paiva et al . 2011 ). Average gene C T values

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0355
Volume/Issue:
Volume 213: Issue 1
Free access
R L Moore Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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Y Dai Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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D V Faller Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of
Cancer Center, Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine, Departments of

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other sirtuins in addition to Sir2p, whereas seven homologs have been identified in mammals, SIRT1–7 ( Frye 1999 , 2000 , Ford et al . 2005 , Yamamoto et al . 2007 ). Sirtuin activities are not limited to histone deacetylation; SIRT members can also

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0217
Volume/Issue:
Volume 213: Issue 1
Free access