Search Results
Health and Kinesiology, Intercollegiate Faculty of Nutrition, Mechanical Engineering, INSERM U890, IFR 143, Université Jean-Monnet, Department of Applied Physiology and Kinesiology and the Center for Exercise Science, Departments of
Health and Kinesiology, Intercollegiate Faculty of Nutrition, Mechanical Engineering, INSERM U890, IFR 143, Université Jean-Monnet, Department of Applied Physiology and Kinesiology and the Center for Exercise Science, Departments of
Health and Kinesiology, Intercollegiate Faculty of Nutrition, Mechanical Engineering, INSERM U890, IFR 143, Université Jean-Monnet, Department of Applied Physiology and Kinesiology and the Center for Exercise Science, Departments of
Search for other papers by Rhonda D Prisby in
Google Scholar
PubMed
Search for other papers by Joshua M Swift in
Google Scholar
PubMed
Health and Kinesiology, Intercollegiate Faculty of Nutrition, Mechanical Engineering, INSERM U890, IFR 143, Université Jean-Monnet, Department of Applied Physiology and Kinesiology and the Center for Exercise Science, Departments of
Search for other papers by Susan A Bloomfield in
Google Scholar
PubMed
Search for other papers by Harry A Hogan in
Google Scholar
PubMed
Health and Kinesiology, Intercollegiate Faculty of Nutrition, Mechanical Engineering, INSERM U890, IFR 143, Université Jean-Monnet, Department of Applied Physiology and Kinesiology and the Center for Exercise Science, Departments of
Search for other papers by Michael D Delp in
Google Scholar
PubMed
declines in bone structural and mechanical properties are observed in the Zucker diabetic fatty (ZDF) rat, a model of type 2 diabetes and 2) to determine whether possible declines in BMD and bone mechanical properties coincide with the onset and progression
Search for other papers by Tetsuhiro Kakimoto in
Google Scholar
PubMed
Search for other papers by Hirotaka Kimata in
Google Scholar
PubMed
Search for other papers by Satoshi Iwasaki in
Google Scholar
PubMed
Search for other papers by Atsushi Fukunari in
Google Scholar
PubMed
Search for other papers by Hiroyuki Utsumi in
Google Scholar
PubMed
and pancreatic islet histology in Zucker diabetic fatty (ZDF) rats, which has not been sufficiently investigated ( Finegood et al . 2001 ). The ZDF rat strain is of increasing preclinical interest, because of its pathophysiological similarities to
Faculty of Kinesiology, Department of Biochemistry and Molecular Biology, Product Safety Labs, Department of Physiology and Biophysics, Factors Group of Nutritional Companies, Canadian Centre for Functional Medicine, University of British Columbia, Faculty of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada T2N 1N4
Search for other papers by Raylene A Reimer in
Google Scholar
PubMed
Faculty of Kinesiology, Department of Biochemistry and Molecular Biology, Product Safety Labs, Department of Physiology and Biophysics, Factors Group of Nutritional Companies, Canadian Centre for Functional Medicine, University of British Columbia, Faculty of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada T2N 1N4
Search for other papers by Gary J Grover in
Google Scholar
PubMed
Search for other papers by Lee Koetzner in
Google Scholar
PubMed
Search for other papers by Roland J Gahler in
Google Scholar
PubMed
Faculty of Kinesiology, Department of Biochemistry and Molecular Biology, Product Safety Labs, Department of Physiology and Biophysics, Factors Group of Nutritional Companies, Canadian Centre for Functional Medicine, University of British Columbia, Faculty of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada T2N 1N4
Search for other papers by Michael R Lyon in
Google Scholar
PubMed
Faculty of Kinesiology, Department of Biochemistry and Molecular Biology, Product Safety Labs, Department of Physiology and Biophysics, Factors Group of Nutritional Companies, Canadian Centre for Functional Medicine, University of British Columbia, Faculty of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta, Canada T2N 1N4
Search for other papers by Simon Wood in
Google Scholar
PubMed
for Care and Use of Laboratory Animals. Sixty six male Zucker diabetic fatty rats (ZDF)/Crl- Leprfa/fa rats were obtained from Charles River (Kingston, NY, USA) at 7–8 week of age and individually housed in a temperature (19–22 °C) and humidity
Search for other papers by Tetsuhiro Kakimoto in
Google Scholar
PubMed
Search for other papers by Kinya Okada in
Google Scholar
PubMed
Search for other papers by Yoshihiro Hirohashi in
Google Scholar
PubMed
Search for other papers by Raissa Relator in
Google Scholar
PubMed
Search for other papers by Mizue Kawai in
Google Scholar
PubMed
Search for other papers by Taku Iguchi in
Google Scholar
PubMed
Search for other papers by Keisuke Fujitaka in
Google Scholar
PubMed
Search for other papers by Masashi Nishio in
Google Scholar
PubMed
Search for other papers by Tsuyoshi Kato in
Google Scholar
PubMed
Search for other papers by Atsushi Fukunari in
Google Scholar
PubMed
Search for other papers by Hiroyuki Utsumi in
Google Scholar
PubMed
diabetic nephropathy, such as Zucker diabetic fatty rats and Otsuka Long-Evans Tokushima fatty (OLETF) rats ( Floege et al . 1992 , Hoshi et al . 2002 , Herrmann et al . 2012 , Sofue et al . 2012 ). Accordingly, the quantification of glomerular
Search for other papers by Rengasamy Palanivel in
Google Scholar
PubMed
Search for other papers by Vivian Vu in
Google Scholar
PubMed
Search for other papers by Min Park in
Google Scholar
PubMed
Search for other papers by Xiangping Fang in
Google Scholar
PubMed
Search for other papers by Gary Sweeney in
Google Scholar
PubMed
increased by 34% and there was no significant difference in free fatty acid levels (0.0245±0.0049 vs 0.0220±0.0072 mM respectively). Figure 5 Changes in the adipokine profile level in wild-type versus STZ-diabetic rat adipocyte-conditioned medium. The level
Search for other papers by Victor Wong in
Google Scholar
PubMed
Search for other papers by Linda Szeto in
Google Scholar
PubMed
Search for other papers by Kristine Uffelman in
Google Scholar
PubMed
Search for other papers by I George Fantus in
Google Scholar
PubMed
Search for other papers by Gary F Lewis in
Google Scholar
PubMed
phosphorylation in Zucker fatty rat skeletal muscle We next examined insulin-signaling proteins downstream of IRS-1 and the results are illustrated in Fig. 2 . Akt protein levels did not differ among the groups in this study. Insulin-stimulated Akt
Search for other papers by Martina Holubová in
Google Scholar
PubMed
Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic
Search for other papers by Jana Zemenová in
Google Scholar
PubMed
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Search for other papers by Barbora Mikulášková in
Google Scholar
PubMed
Search for other papers by Vladimíra Panajotova in
Google Scholar
PubMed
Search for other papers by Jiří Stöhr in
Google Scholar
PubMed
Search for other papers by Martin Haluzík in
Google Scholar
PubMed
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Search for other papers by Jaroslav Kuneš in
Google Scholar
PubMed
Search for other papers by Blanka Železná in
Google Scholar
PubMed
Search for other papers by Lenka Maletínská in
Google Scholar
PubMed
standard diet. In addition to the DIO rat model, the Zucker diabetic rat model, which is a model with impaired leptin receptor signaling ( Fellmann et al . 2013 ), is frequently used for studying the potential of anti-obesity and anti-diabetic peptidic
Search for other papers by Yi Lin in
Google Scholar
PubMed
Search for other papers by Zhongjie Sun in
Google Scholar
PubMed
; require small sample size Homogenous and monogenic inheritance unlike heterogeneity seen in human T2DM Zucker diabetic fatty (ZDF) rat ( Shafrir 1992 ) Hyperglycemia and insulin resistance. Male ZDF rat exhibits impaired insulin secretory β-cell response
Division of Pulmonary, Medicine, Pathology, Pathology, CVGI Discovery, Diabetes Drug Discovery, Allergy, and Critical Care Medicine, Vascular Medicine Institute, Departments of
Search for other papers by Victor P Bilan in
Google Scholar
PubMed
Division of Pulmonary, Medicine, Pathology, Pathology, CVGI Discovery, Diabetes Drug Discovery, Allergy, and Critical Care Medicine, Vascular Medicine Institute, Departments of
Search for other papers by Eman M Salah in
Google Scholar
PubMed
Search for other papers by Sheldon Bastacky in
Google Scholar
PubMed
Search for other papers by Huw B Jones in
Google Scholar
PubMed
Search for other papers by Rachel M Mayers in
Google Scholar
PubMed
Search for other papers by Bradley Zinker in
Google Scholar
PubMed
Search for other papers by Simon M Poucher in
Google Scholar
PubMed
Division of Pulmonary, Medicine, Pathology, Pathology, CVGI Discovery, Diabetes Drug Discovery, Allergy, and Critical Care Medicine, Vascular Medicine Institute, Departments of
Search for other papers by Stevan P Tofovic in
Google Scholar
PubMed
mutations ( fa and fa cp ): the lean female Zucker diabetic fatty rat (ZDF; +/ fa ) and the lean male spontaneously hypertensive heart failure rat (SHHF; +/ fa cp ) derived from the obese spontaneously hypertensive rat carrying the corpulent fa cp gene
Search for other papers by Yuichi Kikuchi in
Google Scholar
PubMed
Search for other papers by Muneharu Yamada in
Google Scholar
PubMed
Search for other papers by Toshihiko Imakiire in
Google Scholar
PubMed
Search for other papers by Taketoshi Kushiyama in
Google Scholar
PubMed
Search for other papers by Keishi Higashi in
Google Scholar
PubMed
Search for other papers by Naomi Hyodo in
Google Scholar
PubMed
Search for other papers by Kojiro Yamamoto in
Google Scholar
PubMed
Search for other papers by Takashi Oda in
Google Scholar
PubMed
Search for other papers by Shigenobu Suzuki in
Google Scholar
PubMed
Search for other papers by Soichiro Miura in
Google Scholar
PubMed
-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41 1422 –1428. Kikuchi Y , Imakiire T, Yamada M, Saigusa T, Hyodo T, Hyodo N, Suzuki S & Miura S 2005 Mizoribine reduces