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AnneMarie Gagnon, Charlie Foster, Anne Landry and Alexander Sorisky

Introduction Obesity-associated insulin resistance is related to adipose tissue inflammation, characterized by macrophage infiltration and altered adipose tissue remodeling, including adipocyte hypertrophy ( Weisberg et al . 2003 , Xu et al

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Eun Hee Koh, Ah-Ram Kim, Hyunshik Kim, Jin Hee Kim, Hye-Sun Park, Myoung Seok Ko, Mi-Ok Kim, Hyuk-Joong Kim, Bum Joong Kim, Hyun Ju Yoo, Su Jung Kim, Jin Sun Oh, Chang-Yun Woo, Jung Eun Jang, Jaechan Leem, Myung Hwan Cho and Ki-Up Lee

include adipose tissue hypoxia ( Ye et al . 2007 , Jiang et al . 2011 ), increased proinflammatory cytokine levels, and oxidative stress in dysfunctional adipocytes ( Otani 2011 ). Another hypothesis that links adipocyte hypertrophy to reduced

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Eriko Inoue, Toshihiro Ichiki, Kotaro Takeda, Hirohide Matsuura, Toru Hashimoto, Jiro Ikeda, Aya Kamiharaguchi and Kenji Sunagawa

, which is one of the causes of insulin resistance ( Savage et al . 2007 ). The hypertrophied adipocytes produce proinflammatory cytokines such as monocyte chemoattractant protein-1 (MCP1 (CCL2)) and tumor necrosis factor-α (TNF-α) as obesity progresses

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Elaine de Oliveira, Egberto G Moura, Ana Paula Santos-Silva, Cíntia R Pinheiro, Natalia S Lima, José Firmino Nogueira-Neto, Andre L Nunes-Freitas, Yael Abreu-Villaça, Magna C F Passos and Patrícia C Lisboa

offspring was associated with an increase in the size of adipocytes (hypertrophy), we performed morphometric analysis on histological sections of visceral and subcutaneous adipose tissue ( Fig. 3 A and B). Quantitative analysis of these sections showed that

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Ricardo Rodríguez-Calvo, Josefa Girona, Josep M Alegret, Alba Bosquet, Daiana Ibarretxe and Lluís Masana

hypertrophy . PLoS ONE 11 e0157372 . ( doi:10.1371/journal.pone.0157372 ) Zhou M Bao Y Li H Pan Y Shu L Xia Z Wu D Lam KS Vanhoutte PM Xu A 2015 Deficiency of adipocyte fatty-acid-binding protein alleviates

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Silva Sütt, Emmelie Cansby, Alexandra Paul, Manoj Amrutkar, Esther Nuñez-Durán, Nagaraj M Kulkarni, Marcus Ståhlman, Jan Borén, Jurga Laurencikiene, Brian W Howell, Sven Enerbäck and Margit Mahlapuu

. 2013 , Amrutkar et al . 2015 a )); however, the physiological function of STK25 in adipocytes remains elusive. On the basis of our previous findings, which reveal a central role of STK25 in control of lipid accumulation, chronic low

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Melissa F Jackson, Dung Luong, Dor Dor Vang, Dilip K Garikipati, James B Stanton, O Lynne Nelson and Buel D Rodgers

hypertrophy ( Morissette et al . 2006 , McKoy et al . 2007 , Rodgers et al . 2009 , Bish et al . 2010 ). Myostatin also circulates and has recently been suggested to regulate hepatic production of IGF1 and several IGF-binding proteins ( Williams et al

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Renato Simões Gaspar, Renata Ohana Alves Benevides, João Lucas de Lima Fontelles, Caroline Castro Vale, Lucas Martins França, Paulo de Tarso Silva Barros and Antonio Marcus de Andrade Paes

exhibited obesity, hypertriglyceridemia, and visceral adipocyte hypertrophy. Additionally, they had irregular estrous cycles, with oligo-ovulation, and increased number of ovarian follicular cysts and atretic follicles. Moreover, our MSG rats presented

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Anthony M Belenchia, Sarah A Johnson, Mark R Ellersieck, Cheryl S Rosenfeld and Catherine A Peterson

hypertrophy was greater in mice gestated in a VDD-deficient intrauterine environment than in those born from a VDS dams ( P  = 0.017; Fig. 4 ). Adipocytes from A vy /a offspring were significantly larger than those from non-obesogenic groups ( P  = 0

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Akiko Mizokami, Satoru Mukai, Jing Gao, Tomoyo Kawakubo-Yasukochi, Takahito Otani, Hiroshi Takeuchi, Eijiro Jimi and Masato Hirata

, insulin resistance, and adipocyte hypertrophy, likely as a result of the promotion of gluconeogenesis in the liver and inflammation in adipose tissue. Our results thus indicate that GLP-1R signaling is necessary for the beneficial actions of GluOC and that