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Xiaojiong Du Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Sirong He Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Yaowen Jiang Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Lingling Wei Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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Weiming Hu Department of Hepatobiliopancreatic Surgery, Laboratory of Transplant Engineering and Immunology, Department of Emergency, Seventh Unit of General Surgery Department

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become the key link that could prolong graft function and survival and improve the success rate of clinical islet transplantation. Adiponectin is the most abundant adipose-specific adipokine that acts as an anti-obesity and anti-inflammatory hormone

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Antonio Gázquez Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Francisca Rodríguez Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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María Sánchez-Campillo Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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Lidia E Martínez-Gascón Department of Clinical Analysis, Biomedical Research Institute of Murcia, Santa Lucia General University Hospital, Murcia, Spain

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Marino B Arnao Department of Plant Biology (Plant Physiology), University of Murcia, Murcia, Spain

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Pedro Saura-Garre Department of Clinical Psychology, University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain

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María D Albaladejo-Otón Department of Clinical Analysis, Biomedical Research Institute of Murcia, Santa Lucia General University Hospital, Murcia, Spain

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Elvira Larqué Department of Physiology, CEIR Campus Mare Nostrum, University of Murcia, Biomedical Research Institute of Murcia, Murcia, Spain

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, who have a higher risk of developing type 2 diabetes and cardiovascular disease ( Bellamy et al. 2009 , Kramer et al. 2019 ). Several cohort studies reported decreased adiponectin concentrations in GDM women compared to their peers without

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Ellen R Lubbers Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Edward O List Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Adam Jara Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Lucila Sackman-Sala Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Jose Cordoba-Chacon Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Manuel D Gahete Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Rhonda D Kineman Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Ravneet Boparai Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Andrzej Bartke Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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John J Kopchick Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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Darlene E Berryman Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine

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adiponectin ( Maeda et al . 1996 ). In humans, adiponectin has been shown to decrease in concentration as fat mass increases, unlike most other adipokines ( Arita et al . 1999 , Kern et al . 2003 ). Thus, adiponectin is considered a beneficial adipokine

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Taira Wada Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Yukiko Yamamoto Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Yukiko Takasugi Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Hirotake Ishii Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Taketo Uchiyama Laboratory of Organic Chemistry, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Kaori Saitoh Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

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Masahiro Suzuki Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

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Makoto Uchiyama Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
Tokyo Adachi Hospital, Adachi, Tokyo, Japan

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Hikari Yoshitane Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Yoshitaka Fukada Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Shigeki Shimba Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Introduction Adiponectin is a humoral factor that is abundantly secreted by adipocytes ( Scherer et al. 1995 , Hu et al. 1996 , Maeda et al. 1996 , Nakano et al. 1996 ). Adiponectin levels are reduced in obese individuals ( Arita

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Sujith Rajan Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Ganesh Panzade Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Ankita Srivastava Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Kripa Shankar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Rajesh Pandey CSIR Ayurgenomics Unit-TRISUTRA, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

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Durgesh Kumar Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Sanchita Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Abhishek Gupta Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Salil Varshney Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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Muheeb Beg Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India

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Raj Kumar Mishra SIPS Superspeciality Hospital, Lucknow, India

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Ravi Shankar Studio of Computational Biology and Bioinformatics, Biotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
Academy of Scientific and Innovative Research, CSIR-IHBT, Palampur, India

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Anil Gaikwad Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow, India
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India

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important to understand the pathophysiology of IR and type 2 diabetes. Recently, several miRNAs such as miR-378 and miR-193b have been shown to regulate the expression of adiponectin (Belarbi et al . 2015, Chen et al . 2015 , Gao et al . 2015 , Li et

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Eun Hee Koh Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Ah-Ram Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyunshik Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jin Hee Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hye-Sun Park Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Myoung Seok Ko Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Mi-Ok Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyuk-Joong Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Bum Joong Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Hyun Ju Yoo Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Su Jung Kim Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jin Sun Oh Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Chang-Yun Woo Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jung Eun Jang Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Jaechan Leem Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Myung Hwan Cho Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Ki-Up Lee Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea

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Introduction Adiponectin, the most abundant protein in adipocytes, has many favorable effects on metabolism, including improvement of insulin action and reduction of atherosclerotic processes ( Ouchi et al . 2001 , Yamauchi et al . 2003

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Gabriela Capllonch-Amer Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Miquel Sbert-Roig Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Bel M Galmés-Pascual Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Ana M Proenza Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Isabel Lladó Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Magdalena Gianotti Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Francisco J García-Palmer Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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adiponectin levels in serum. Adiponectin is an insulin-sensitizing hormone secreted mainly by white adipose tissue (WAT; Harwood 2012 ). Circulating levels of adiponectin show sexual dimorphism in both humans and rodents, with females presenting higher serum

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Thanh Q Dang Department of Biology, Faculty of Science York University, Toronto, Canada

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Nanyoung Yoon Department of Biology, Faculty of Science York University, Toronto, Canada

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Helen Chasiotis Department of Biology, Faculty of Science York University, Toronto, Canada

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Emily C Dunford School of Kinesiology and Health Science, Faculty of Health and Muscle Health Research Center, York University, Toronto, Canada

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Qilong Feng Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

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Pingnian He Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA, USA

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Michael C Riddell School of Kinesiology and Health Science, Faculty of Health and Muscle Health Research Center, York University, Toronto, Canada

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Scott P Kelly Department of Biology, Faculty of Science York University, Toronto, Canada

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Gary Sweeney Department of Biology, Faculty of Science York University, Toronto, Canada

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with 50 µg/mL Neomycin (Sigma-Aldrich) for 24 h, cells were seeded onto inserts for analysis of TEER, examining adiponectin flux or preparation of cell lysates to confirm claudin-7 knockdown. Transendothelial electrical resistance (TEER), and [3H

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Delphine Benaitreau
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Esther Dos Santos
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Marie-Christine Leneveu
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Nadia Alfaidy Service de Biochimie et Biologie Moléculaire, INSERM U878. Commissariat à l'Energie Atomique, UPRES-EA 2493, Faculté de Médecine Paris-Ile de France Ouest, PRES Universud Paris, Centre Hospitalier de Poissy-Saint Germain, Université de Versailles-St-Quentin, 78303 Poissy Cedex, France

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Jean-Jacques Feige Service de Biochimie et Biologie Moléculaire, INSERM U878. Commissariat à l'Energie Atomique, UPRES-EA 2493, Faculté de Médecine Paris-Ile de France Ouest, PRES Universud Paris, Centre Hospitalier de Poissy-Saint Germain, Université de Versailles-St-Quentin, 78303 Poissy Cedex, France

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Philippe de Mazancourt
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René Pecquery
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Marie-Noëlle Dieudonné
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signaling mediated by growth factors, cytokines, and hormones of both fetal and maternal origin ( Bischof et al . 2000 , Cohen & Bischof 2007 , Knofler et al . 2008 ). Adiponectin, a hormone mainly produced in adipose tissue, has been described as an

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Umberto Simeoni Division of Pediatrics & DOHaD Laboratory, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland

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Clive Osmond MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK

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Ricardo Garay Craven, Villemoisson-sur-Orge, France

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Christophe Buffat Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital de la Conception, Marseille, France

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Farid Boubred Division of Neonatology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Christophe Chagnaud Division of Radiology and Medical Imaging, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Elisabeth Jouve UPCET, Clinical Pharmacology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Christine Audebert UPCET, Clinical Pharmacology, Assistance Publique, Hôpitaux de Marseille, Marseille, France

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Jean-Michel Antoine Danone Institute International, Paris, France

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Kent Thornburg Bob and Charlee Moore Institute for Nutrition and Wellness, Oregon Health & Science University, Portland, Oregon, USA

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on the time sequence across the period of the life course which separates early programming and the occurrence of disease at late adulthood. Adipokines, such as leptin and adiponectin, and the pancreatic hormone insulin work in harmony to regulate

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