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become the key link that could prolong graft function and survival and improve the success rate of clinical islet transplantation. Adiponectin is the most abundant adipose-specific adipokine that acts as an anti-obesity and anti-inflammatory hormone
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, who have a higher risk of developing type 2 diabetes and cardiovascular disease ( Bellamy et al. 2009 , Kramer et al. 2019 ). Several cohort studies reported decreased adiponectin concentrations in GDM women compared to their peers without
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Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
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Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
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Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
Edison Biotechnology Institute, Department of Biomedical Sciences, School of Applied Health Sciences and Wellness, Jesse Brown VA Medical Center, Southern Illinois University School of Medicine
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adiponectin ( Maeda et al . 1996 ). In humans, adiponectin has been shown to decrease in concentration as fat mass increases, unlike most other adipokines ( Arita et al . 1999 , Kern et al . 2003 ). Thus, adiponectin is considered a beneficial adipokine
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Tokyo Adachi Hospital, Adachi, Tokyo, Japan
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Introduction Adiponectin is a humoral factor that is abundantly secreted by adipocytes ( Scherer et al. 1995 , Hu et al. 1996 , Maeda et al. 1996 , Nakano et al. 1996 ). Adiponectin levels are reduced in obese individuals ( Arita
Academy of Scientific and Innovative Research, CSIR-CDRI, Lucknow, India
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important to understand the pathophysiology of IR and type 2 diabetes. Recently, several miRNAs such as miR-378 and miR-193b have been shown to regulate the expression of adiponectin (Belarbi et al . 2015, Chen et al . 2015 , Gao et al . 2015 , Li et
Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Department of Internal Medicine, Biomedical Research Center, Department of Biological Sciences, University of Ulsan College of Medicine, 88 Olympic‐ro 43‐gil, Songpa‐gu, Seoul 138‐736, Korea
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Introduction Adiponectin, the most abundant protein in adipocytes, has many favorable effects on metabolism, including improvement of insulin action and reduction of atherosclerotic processes ( Ouchi et al . 2001 , Yamauchi et al . 2003
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
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adiponectin levels in serum. Adiponectin is an insulin-sensitizing hormone secreted mainly by white adipose tissue (WAT; Harwood 2012 ). Circulating levels of adiponectin show sexual dimorphism in both humans and rodents, with females presenting higher serum
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with 50 µg/mL Neomycin (Sigma-Aldrich) for 24 h, cells were seeded onto inserts for analysis of TEER, examining adiponectin flux or preparation of cell lysates to confirm claudin-7 knockdown. Transendothelial electrical resistance (TEER), and [3H
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signaling mediated by growth factors, cytokines, and hormones of both fetal and maternal origin ( Bischof et al . 2000 , Cohen & Bischof 2007 , Knofler et al . 2008 ). Adiponectin, a hormone mainly produced in adipose tissue, has been described as an
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on the time sequence across the period of the life course which separates early programming and the occurrence of disease at late adulthood. Adipokines, such as leptin and adiponectin, and the pancreatic hormone insulin work in harmony to regulate